Abstract:In Reply.—
Mr Schriver's first concern is the appropriate interpretation of results from placebo-controlled, double-blind clinical trials. Our understanding is that the function of the placebo-treated group is to provide a control against which to judge the effect of the treatment. It is not particularly unusual to observe an "effect" in the placebo "arm" of such a controlled study, and we would consider it inappropriate to emphasize the effect in either arm considered by itself other than in re… Show more
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