Schönlein–Henoch Purpura

Ott, Hagen

doi:10.1002/9781444345384.ch160

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…Histopathologic examination of skin in HSP shows segmental inflammation of vessels, swollen endothelial cells, fibrinoid necrosis of blood vessel walls and infiltrates around vascular, called leukocytoclastic vasculitis. In this patient, the skin biopsy results revealed a hypocellular smear consisting of hyperkeratosis, red blood cell extravasation, with a distribution of squamous epithelial cells along with extensive neutrophilic inflammatory cells and lymphocytes compatible with leukocytoclastic vasculitis (22,23). Some cases of Henoch-Schonlein Purpura (HSP) are self-limiting and do not require treatment.…”

Section: Discussionmentioning

confidence: 91%

Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children

Wardhani

Saroh

2023

MMJ

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Henoch-Schonlein Purpura (HSP) is systemic vasculitis in children, hallmark by inflammatory infiltration of polymonuclear leukocytes in small blood vessels, followed by IgA1 immune deposits. HSP prevalence is approximately 3-27 cases per 100,000 children. The inflammatory process in HSP causes an ischemia and hemorrhagic process characterized by non-thrombocytopenia purpura, arthralgia, gastrointestinal problems, and kidney impairment. This process is called leukocytoclastic vasculitis. A 10-year-old boy came to ER of Dr. Sayidiman Magetan Hospital presenting with diffuse abdominal pain and purpura skin lesions in body. The complaint started with a red rash on both legs, then progressively extended to both hands, thighs, and buttocks, and continued with severe abdominal discomfort, nausea, dizziness, fever, and the patient also experienced a brownish-black stool. The patient was diagnosed with Henoch-Schonlein purpura with gastrointestinal manifestations based on medical examination. The patient stayed for six days at the hospital, and the condition improved.

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Section: Discussionmentioning

confidence: 91%

Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children

Wardhani

Saroh

2023

MMJ

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An 8-Month-Old Boy with Purpuric Skin Lesions

Sorensen¹,

Matiz²,

Friedlander³

2014

Pediatr Ann

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A previously healthy 8-month-old Hispanic boy presented with a 5-day history of an erythematous, non-pruritic papular eruption on both legs. The eruption was initially diagnosed as impetigo by his primary care practitioner but progressed despite trimethoprim / sulfamethoxazole therapy, with extension to the face, trunk, and all extremities. When the patient subsequently developed a fever of 100.8° F, emesis, diarrhea, and upper respiratory symptoms, he was referred to the pediatric dermatology clinic for evaluation. Further questioning revealed a 3-day febrile illness 6 weeks prior to presentation that was treated with ceftriaxone. Review of systems failed to identify any hematuria, blood in stool, or abdominal pain, but the parents did report swelling of the extremities and face, as well as decreased oral intake. On examination, the infant was in no apparent distress, afebrile, and had mild rhinorrhea. His mucous membranes were unaffected, and no lymphadenopathy or hepatosplenomegaly was noted. Cutaneous exam revealed numerous edematous erythematous to violaceous plaques on the cheeks, arms, buttocks, and legs with minimal involvement of the trunk. Several lesions on the arms had a distinct cockade (rosette or iris-like) pattern. There were no vesicles, bullae, or necrosis. Edema of the bilateral lower extremities was noted. Laboratory work up revealed a normal complete blood count (CBC), comprehensive metabolic panel, creatinine, and urinalysis. Platelets were borderline elevated at 439 TH/μL (140-440 TH/μL), and erythrocyte sedimentation rate and C-reactive protein (CRP) were minimally elevated at 22 mm (0-15 mm) and 3.1 mg/dL (0.0-0.99 mg/dL), respectively.

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Schönlein–Henoch Purpura

Cited by 2 publications

References 42 publications

Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children

Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children

An 8-Month-Old Boy with Purpuric Skin Lesions

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