Schnelltest-Diagnostik sexuell übertragbarer Infektionen in niedrigschwelligen Einrichtungen

Meyer, Thomas; Schüttler, Christian G.; Straube, Eberhard; Roß, R. Stefan; Stürmer, Martin; Jansen, Klaus; Buder, Susanne; Nick, Sigrid; Hagedorn, Hans‐Jochen; Bremer, Viviane; Brockmeyer, Norbert H.

doi:10.1007/s00103-016-2496-3

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…With a technically well evaluated diagnostics-as-prevention approach covering a broad spectrum of STIs, sexual risk-taking populations could greatly reduce their STI transmission risk. However, test characteristics have to be considered and beyond HIV testing, presently available rapid tests score poorly compared with the diagnostic gold standard assays [19].…”

Section: The Diagnostics-as-prevention Conceptmentioning

confidence: 99%

Diversification of the Prevention of Sexually Transmitted Infections

Frickmann

2019

Future Microbiol.

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Section: The Diagnostics-as-prevention Conceptmentioning

confidence: 99%

Diversification of the Prevention of Sexually Transmitted Infections

Frickmann

2019

Future Microbiol.

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“…pdf Accessed 25 June 2018) or if there is the risk of poor compliance with condom use because of intended use of psychoactive substances prior to sexual activity (Rehm et al 2012). Ideally, medical counselling could be associated with cases of positive results; accordingly, a lowthreshold medical infrastructure wherein counselling could be performed prior to any planned adventurous sexual activity would be an ideal situation for such an approach (Meyer et al 2017). In such settings, a molecular RDT-based prevention strategy could contribute to risk reduction regarding the exposure to STDs.…”

Section: Resultsmentioning

confidence: 99%

PCR-based rapid diagnostic tests as a strategy for preventing infections with sexually transmitted diseases-a ‘diagnostics-as-prevention’ modelling approach

Hahn

Schwarz

Meyer

et al. 2018

Lett Appl Microbiol

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A low-threshold use of molecular rapid diagnostic tests in settings where risky sexual activity is undertaken with deliberate non-use of condoms is modelled. Such an approach might contribute to a considerable reduction in the exposure risk if positively tested individuals are excluded from unprotected sexual intercourse. Protective effects are influenced by the prevalence of the disease and the performance characteristics of the applied tests. Precise knowledge of the performance characteristics of the test assays employed are prerequisites of a reliable risk assessment. The modelling approach is of particular use for preventive health experts.

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“…Finally, regarding the p24 antigen component, the specificity is 99.7% (CI 96.8–100) and the sensitivity 12.3% (CI 1.1–44.2), indicating a poor sensitivity for p24 detection. A slightly increased sensitivity in acute infections was observed for the successor of the Determine HIV1/2 Ag/Ab Combo test, a 4th-generation RDT (HIV Combo, Alere Inc.) [19].…”

Section: Introductionmentioning

confidence: 99%

HIV prevention strategies and risk of infection: a model-based analysis

et al. 2018

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Risk populations for HIV infections tend to neglect condom use, making alternative preventive approaches necessary. Accordingly, we modelled the risk of sexual HIV transmission for condom use vs. use of rapid diagnostic test (RDT) systems with subsequent exclusion of potential sexual partners with a correctly or falsely positive test from unprotected sex with and without the use of HIV pre-exposure prophylaxis (PrEP) in a bio-statistical approach. We combined a previously described model of transmission risk for HIV-exposed individuals with a newly suggested model of risk of HIV exposure for sexually active HIV-negative individuals. The model was adapted for several stages of infection and different strategies of HIV infection prevention.HIV prevention with RDTs can reduce the transmission risk by up to 97% compared with having sex without any prevention and up to 80% compared with condom use. Nevertheless, RDT-based prevention strategies demonstrate a lack of protection in several stages of infection; in particular, RNA-based RDT systems may fail under treatment. RDT-based pre-screening of potential sex partners prior to unprotected sexual contacts substantially reduces HIV transmission risk. Combination of different prevention strategies is advisable for high-risk groups.

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Schnelltest-Diagnostik sexuell übertragbarer Infektionen in niedrigschwelligen Einrichtungen

Cited by 16 publications

References 47 publications

Diversification of the Prevention of Sexually Transmitted Infections

Diversification of the Prevention of Sexually Transmitted Infections

PCR-based rapid diagnostic tests as a strategy for preventing infections with sexually transmitted diseases-a ‘diagnostics-as-prevention’ modelling approach

HIV prevention strategies and risk of infection: a model-based analysis

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