Schnellmethode zur Beurteilung Der UrÄmie Als Ersatz Der Reststickstoff-Bestimmung

Pópper, Hans; Mandel, Emil; Mayer, H.O.

doi:10.1007/bf01779466

Cited by 8 publications

(6 citation statements)

References 2 publications

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“…Creatinine was determined using the Jaffe's reaction according to Popper et al, (1937). The glomerular filtration rate was determined using inulin clearance according to Führ et al, (1955).…”

Section: Methodsmentioning

confidence: 99%

Effect Of Chronic Exposure To Low Levels Of Lead On Renal Function And Renal Ultrastructure In SD Rats

et al. 2005

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Summary: Chronic exposure to lead is associated with adverse effects on renal function in laboratory animals and man. There is controversy concerning the direction of change of renal function parameters following chronic lead intoxication. The renal effects of low-dose lead exposure, as opposed to acute and pharmacological doses, require further scrutiny. In order to determine the effect of prolonged lowdose lead exposure, male Sprague Dawley rats (initial weight, 150.5±17.4g; final weight, 300.5±17.4g; n=10) administered lead acetate (100 p.p.m.) in drinking water over a period of 3 months, were investigated for renal function parameters. Treated rats had elevated blood pressures (114.4±4.2 vs. 95.7±3.5 mmHg; P<0.01). There was no significant difference in renal blood flow (3.99±0.28 vs. 4.19±0.63 ml/min; P=NS). GFR was comparable in the two groups (0.77±0.05 vs. 0.88±0.06 ml/min; P=NS). No significant difference in serum creatinine was observed (57.8±7.5 vs. 49.0±2.7 μmol/l; P=NS). Renal histology showed minimal interstitial changes in the experimental group. Interestingly, significant sodium (P<0.01); potassium (P<0.05) and chloride (P<0.05) retention were observed in the lead treated rats. Elevation of blood pressure occurred at a stage when low-level lead exposure did not alter renal function parameters appreciably. These results suggest that hypertension may be a forerunner of significant renal damage following chronic exposure to low-levels of lead and further underscore fluid and electrolyte retention as a significant mechanism responsible for elevated blood pressure in the chronic stages of lead exposure.

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Section: Methodsmentioning

confidence: 99%

Effect Of Chronic Exposure To Low Levels Of Lead On Renal Function And Renal Ultrastructure In SD Rats

et al. 2005

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“…Diuresis was calculated as milliliters per minute per standard body area (1.73 m 2 ). Measured in each urine sample were: osmolality using a MT-2 osmometer based on determination of freezing point depression (Burevestnik, Russia), creatinine concentration using Jaffe's reaction with picric acid by the method of Popper et al [19] with a SF-16 spectrophotometer (LOMO, Russia), sodium and potassium concentrations using a flame photometer (Corning-410, UK), and calcium and magnesium concentrations using an atomic absorption spectrophotometer (Hitachi 508, Japan).…”

Section: Renal Function In Nocturnal Enuresismentioning

confidence: 99%

Nocturnal enuresis: correction of renal function by desmopressin and diclofenac

Natochin¹,

2000

Pediatric Nephrology

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Sixty-two children with nocturnal enuresis (43 boys, 19 girls aged 6-15 years) were treated with either desmopressin (Adiuretin-SD) (n = 32) or sodium diclofenac (n = 30). Desmopressin was effective in 85% of children and diclofenac in 33%. In children with primary nocturnal enuresis, the glomerular filtration rate was normal, whereas diuresis and solute excretion during the night were increased. Compared with healthy children, the nightly excretion of sodium was elevated by 43.7% and magnesium by 58.4%. A high correlation was found between the free water reabsorption and solute clearance (P < 0.001) in children with nocturnal enuresis. Changes in kidney function in nocturnal enuresis appear to be due to a decrease in the water and ion reabsorption in the thick ascending limb of Henle's loop because of a changed regulation of ion transport in this part of the nephron. Administration of desmopressin or a decrease in prostaglandin production after diclofenac administration restores the ion and water transport in the kidney, which results in the disappearance of nocturnal enuresis. The results indicate a role of changes in regulation of ion transport in renal tubules in the pathogenesis of one of the forms of primary nocturnal enuresis.

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“…The level of creatinine in blood, however, can indicate a considerable reduction of the filtration rate at a still normal urea value. Even Popper, Mandel, and Meyer's method (27) for the rapid estimation of renal deficiency, which is a qualitative determination of creatinine in blood performable within 3 minutes at the bedside, often indicates pathological results when the urea level of the blood is still normal.…”

Section: The Diagnostic Value Of Plasma Creatinine and Endogenous Crementioning

confidence: 99%

The Determination of the Glomerular Filtration by the Endogenous Creatinine Clearance 1

Steinitz¹,

Türkand²

1940

J. Clin. Invest.

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Schnellmethode zur Beurteilung Der UrÄmie Als Ersatz Der Reststickstoff-Bestimmung

Cited by 8 publications

References 2 publications

Effect Of Chronic Exposure To Low Levels Of Lead On Renal Function And Renal Ultrastructure In SD Rats

Effect Of Chronic Exposure To Low Levels Of Lead On Renal Function And Renal Ultrastructure In SD Rats

Nocturnal enuresis: correction of renal function by desmopressin and diclofenac

The Determination of the Glomerular Filtration by the Endogenous Creatinine Clearance 1

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