Schmidt's syndrome in a dog: a case report

Abstract

This report describes a clinical case and development of the polyglandular failure syndrome including hypothyroidism and hypoadrenocorticism in a 6-year-old female Black Russian Terrier. The bitch was presented because of hypothyroidism on the first occasion. Oral supplementation with sodium levothyroxine resulted in clinical improvement. Four months later, it was presented again with similar and rather vague clinical signs and diagnosed with adrenocortical deficiency both in mineralocorticoid and glucocorticoid functions. Indirect immunofluorescence to investigate the presence of circulating autoantibodies against the thyroid and adrenal glands revealed only anti-thyroid antibodies (microsomal pattern) at a dilution of 1:40. Since then, the bitch has been on hydrocortisone and fludrocortisone with no adjustments necessary for a year. The combination of two endocrinopathies and the episodic course of hypoadrenocorticism made the final diagnosis difficult, posed a diagnostic challenge and required the owner’s compliance with diagnostic and therapeutic procedures.

Polyglandular endocrinopathy type II (Schmidt's syndrome) in a Dobermann pinscher

“…In this case, as with previous reports, hypothyroidism was diagnosed first, followed by hypoadrenocorticism (Pikula et al . , Kooistra et al . ).…”

“…Another dog is reported with typical hypoadrenocorticism (mineralocorticoid and glucocorticoid deficiencies) in addition to hypothyroidism (Pikula et al . ). To date none of the reports of comorbid hypothyroidism and glucocorticoid‐deficient hypoadrenocorticism have demonstrated immune‐mediated adrenalitis.…”

Hypoadrenokortizismus beim Hund – ein Update zu Pathogenese, Diagnose und Therapie

“…Ähnlich wie beim Morbus Addison des Menschen kann die immunmediierte Zerstörung der NNR auch beim Hund zeitgleich zu anderen primär immunmediierten Endokrinopathien, wie Hypothyreose, Diabetes mellitus und Hypoparathyreoidismus, auftreten (11,36,58,72). Bisher wurde beim Hund insbesondere das gemeinsame Vorliegen eines HoAK und einer Hypothyreose beschrieben (2,11,53,63).…”

Cardiogenic Pulmonary Edema in a Dog Following Initiation of Therapy for Concurrent Hypoadrenocorticism and Hypothyroidism

“…Polyendocrinopathies have been reported in only single case reports or small case series in veterinary medicine, so there is a lack of information about successful treatments for combined hypoadrenocorticism and hypothyroidism in dogs. [1][2][3] Endocrine hormone deficiencies have been associated with cardiac dysfunction and heart failure. Among hormone deficiencies causing cardiac abnormalities in humans, the most consistently reported is hypothyroidism.…”