Schluckbezogene Lebensqualität bei Mundhöhlenkarzinomen

Bauer, F.; Seiss, M.; Gräßel, Elmar; Stelzle, Florian; Klotz, Michael; Rosanowski, F.

doi:10.1007/s00106-010-2117-7

Cited by 19 publications

(11 citation statements)

References 15 publications

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“…The questionnaire is easy to understand and contains questions regarding subjective functional impairment from oropharyngeal dysphagia, whereas symptom-specific quality of life is not as thoroughly addressed [ 19 ]. Comparable validated dysphagia-specific questionnaires in German-speaking countries include the SWAL-QOL [ 30 ] and the MD Anderson Dysphagia Inventory [ 31 ], which primarily assess swallowing-related quality of life, and the Eating Assessment Tool-10 [ 32 ], which serves as a screening rather than a monitoring tool. Regarding the SSQ, a recent work on screening for oropharyngeal dysphagia in adult patients with neuromuscular diseases showed that the individual item scores for most questions included in the SSQ correlated with the total SSQ score in SMA [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Bulbar Function in Adult Patients with 5q-SMA Type 2 and 3 under Treatment with Nusinersen

Brakemeier¹,

Stolte²,

Thimm³

et al. 2021

Brain Sciences

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The antisense oligonucleotide nusinersen has been shown to improve trunk and limb motor function in patients with spinal muscular atrophy (SMA). Bulbar dysfunction, which is regularly present in SMA, is not captured by standard motor scores, and validated measurement instruments to assess it have not yet been established. Data on whether and how bulbar function changes under gene-based therapies in adult SMA patients are also unavailable. Here, we present data on the course of bulbar dysfunction assessed prospectively before nusinersen treatment initiation and 6 and 14 months later in 23 adult SMA patients using the Sydney Swallow Questionnaire (SSQ) and the bulbar subscore of the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R). While no improvement in bulbar scores was observed under treatment with nusinersen, the absence of a decline still implies a therapeutic effect of nusinersen on bulbar dysfunction. The results of this study aim to contribute to a standardized assessment of bulbar function in adult SMA patients, which may show therapeutic effects of gene-based therapies that are not evident from standard motor scores.

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Section: Discussionmentioning

confidence: 99%

Assessment of Bulbar Function in Adult Patients with 5q-SMA Type 2 and 3 under Treatment with Nusinersen

Brakemeier¹,

Stolte²,

Thimm³

et al. 2021

Brain Sciences

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“…Each question can be scored 1–5 points. A value of less than 55 is considered “highly noticeable”, 55–70 “rather noticeable” and greater than 70 “not noticeable” [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Systematic evaluation of laryngeal impairment in Sjögren’s syndrome

Graf

Kirschstein

Knopf

et al. 2021

Eur Arch Otorhinolaryngol

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Introduction Sjögren’s syndrome (SjS) causes malfunction of the salivary and lacrimal glands. Consequently, patients suffer from xerostomia and keratoconjunctivitis sicca. This can further affect the voice and swallowing function resulting in an impaired quality of life. Aim of this study is the systematic evaluation of the impact on voice and swallowing-related quality of life in patients with SjS. Material and methods SjS patients were classified according to the American–European Consensus Group (AECG) criteria; antibodies to Ro (SS-A) or La (SS-B) antigens were detected, ESSPRI was completed. We used the following quality of life questionnaires: EORTC QLQ H&N 35, Anderson Dysphagia Inventory (ADI) and Voice Handicap Index (VHI). Patients additionally received a detailed phoniatric examination (auditory perception, videostroboscopy, acoustic analysis, Dysphonia Severity Index (DSI), aerodynamics measurements). Results Almost all the 54 patients (96.3%) had a limited quality of life due to their swallowing problems and 48% due to their voice problems. Both values correlated significantly with the degree of xerostomia. In the phoniatric examination, 77.8% had an increased DSI and two-thirds had abnormalities in videostroboscopy. Conclusions A reasonable impairment of quality of life in patients with SjS due to the limitations in voice and swallowing function was observed. As SjS does not limitate life expectancy, preservation of quality of life is important. Detection of voice and swallowing problems as potential reasons for quality of life impairment should be detected and, if diagnosed, treated accordingly.

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“…Für den gEAT-10 wurde diese Berechnung bisher nicht durchgeführt. Auch für das MD Anderson Dysphagia Inventory (MDADI) [21] existiert eine deutsche Übersetzung (ADI-D), für die Validität und Reliabilität gezeigt wurde [20], die jedoch ebenfalls nur eine grobe Einteilung in "sicher auffällig", "eher auffällig" und "eher unauffällig" erlaubt. Mit 30 Items ist die Befragung jedoch aufwendiger.…”

Section: Statistische Methodenunclassified

“…An der Klinik bestanden auch Erfahrungen mit der deutschen Version (ADI-D) [20] des MD Anderson Dysphagia Inventory (MDADI) [21], wobei auch für die deutsche Übersetzung Validität und Reliabilität gezeigt wurden [Bauer 2010]. Die deutsche Version des MDADI, ADI-D, besteht aus insgesamt 30 Fragen, die in der Originalpublikation 4 Kernbereichen zugeordnet sind, nämlich dem globalen, dem emotionalen, dem funktionellen und dem physischen.…”

Section: Introductionunclassified

Beeinflussung von strukturellen Dysphagien durch eine phoniatrische Rehabilitation

Keilmann¹,

Wach²,

Konerding

2021

Laryngorhinootologie

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ZusammenfassungPatienten, die wegen Kopf-Hals-Tumoren behandelt wurden, leiden häufig an Dysphagien. Dysphagien können mittels Fragebögen, die die Betroffenen ausfüllen, oder über Expertenratings, die z. B. die Konsistenz der Nahrung, die Dauer der Nahrungsaufnahme, die Notwendigkeit einer perkutanen endoskopischen Gastrostomie (PEG) und die Ergebnisse instrumenteller Untersuchungen wie der fiberoptischen endoskopischen Evaluation des Schluckens (FEES) berücksichtigen, bewertet werden. Das Ziel unserer Studie war die Untersuchung des Effekts einer phoniatrischen stationären Rehabilitation bei Patienten, die wegen eines Kopf-Hals-Tumors behandelt worden waren. Zu Beginn und am Ende der Reha füllten die 219 Teilnehmer (davon 138 Männer) im mittleren Alter von 62,8 (± 10,2) Jahren die deutsche Version des Eating Assessment Tools (EAT-10) aus und sie wurden anhand des Bogenhausener Dysphagie-Scores (BODS) unter Berücksichtigung von anamnestischen und klinischen Daten klassifiziert.In beiden Parametern ergaben sich signifikante Verbesserungen, aber beide Parameter waren nur mäßig korreliert. Die Veränderungen in beiden Parametern waren nicht korreliert.Zur Untersuchung von Dysphagien sollten sowohl klinische Einschätzungen als auch die subjektive Beurteilung erfasst werden

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Schluckbezogene Lebensqualität bei Mundhöhlenkarzinomen

Abstract: The German translation of the ADI is a validated and reliable method to assess swallowing-related quality of life.

Cited by 19 publications

References 15 publications

Assessment of Bulbar Function in Adult Patients with 5q-SMA Type 2 and 3 under Treatment with Nusinersen

Assessment of Bulbar Function in Adult Patients with 5q-SMA Type 2 and 3 under Treatment with Nusinersen

Systematic evaluation of laryngeal impairment in Sjögren’s syndrome

Beeinflussung von strukturellen Dysphagien durch eine phoniatrische Rehabilitation

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