Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA
Peng Zhang,
Xiaoqing Hu,
Zekun Li
et al.
Abstract:Nucleic acids are major structures detected by the innate immune system. Although intracellular single-stranded DNA (ssDNA) is accumulated during pathogen infection or pathogenesis, it remains unclear whether and how intracellular ssDNA stimulates the immune system. We report that intracellular ssDNA triggers cytokine expression and cell death in a CGT motif-dependent manner. Through a genome-wide CRISPR‒Cas9 screen, we identified Schlafen-11 (SLFN11), which is essential for the response to endogenous and path… Show more
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