Schizophrenie und Depression

Maurer, Kurt; Trendler, Günter; Schmidt, Martin H.; Heiden, Wolfram an der; Könnecke, R.; Häfner, Heinz

doi:10.1007/s00115-005-1920-y

Cited by 14 publications

(5 citation statements)

References 76 publications

(80 reference statements)

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“…Thus, some hypotheses and theories in this direction possibly need to be re-examined. For example, our results do not strongly support the empirical findings and further hypotheses of Häfner and colleagues [17, 27] that due to a low threshold, depressive symptoms are widespread in the population and independent of frank psychosis with a significant higher threshold. Our findings propose suggest strongly that schizotypal symptoms preferably convey depression symptoms, which for their part can convey schizophrenia nuclear symptoms.…”

Section: Discussioncontrasting

confidence: 99%

Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study

Rössler

Angst

Gamma

et al. 2010

Eur Arch Psychiatry Clin Neurosci

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The interplay of psychotic and affective symptoms is a crucial challenge in understanding the pathogenesis of psychosis. In this study, we analyzed the interplay between two subclinical psychosis symptoms dimensions, and one depression symptoms dimension, using longitudinal data from Zurich. The Zurich study started in 1979 with a representative sample of 591 participants who were aged 20/21. Follow-up interviews were conducted at age 23, 28, 30, 35, and 41. The psychiatric symptoms were assessed with a semi-structured interview and the SCL 90-R. In this study, we analyzed three SCL-90-R subscales: the depression symptoms dimension and two distinct symptoms dimensions of subclinical psychosis, one representing a schizophrenia Springer-Verlag 2010 Correspondence to: Wulf Rössler. Electronic supplementary material The online version of this article (doi:10.1007/s00406-010-0123-0) contains supplementary material, which is available to authorized users. NIH Public AccessAuthor Manuscript Eur Arch Psychiatry Clin Neurosci. Author manuscript; available in PMC 2011 February 1. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript nuclear symptom dimension, the other representing a schizotypal symptoms dimension. Modeling was done with hybrid latent growth models, thereby including simultaneous and cross-lagged effects. The interplay between the two subclinical psychosis symptoms dimensions and the depression symptoms dimension includes several intertwined pathways. The schizotypal symptoms dimension has strong direct effects on the schizophrenia nuclear symptoms dimension, but also on the depression symptoms dimension. The latter has for its part an effect on the schizophrenia nuclear symptoms dimension. The main driving force within the dynamic interplay between depression and psychosis symptoms is a schizotypal symptoms dimension, which represents social and interpersonal deficiencies, ideas of reference, suspiciousness, paranoid ideation, and odd behavior. It does not only directly influence subclinical nuclear schizophrenia symptoms but also the symptoms of depression.

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Section: Discussioncontrasting

confidence: 99%

Reappraisal of the interplay between psychosis and depression symptoms in the pathogenesis of psychotic syndromes: results from a twenty-year prospective community study

Rössler

Angst

Gamma

et al. 2010

Eur Arch Psychiatry Clin Neurosci

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“…This is in line with findings concerning other severe psychiatric disorders, such as schizophrenia and bipolar disorder. Several researchers have postulated that the prodromal phase of these disorders is characterized by rather unspecific symptoms, especially having an unspecific depressive-anxious feature, and later, more specific symptoms lead to a psychopathologically characteristic early course of a distinct disease (Maurer et al, 2006). This fits to the well-known results of a lot of high-risk studies, which all revealed that an unspecific disposition for any psychopathological disturbance was shown by high-risk persons.…”

Section: Discussionmentioning

confidence: 56%

Early Recognition of Obsessive-Compulsive Disorder

Juckel

Siebers

Kienast³

et al. 2014

Journal of Nervous &Amp; Mental Disease

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The early course in clinical and neurobiological terms of obsessive-compulsive disorder (OCD) is almost completely unknown. The disease often begins in early childhood and adolescence, but the first behavioral changes and symptoms preceding OCD have not been assessed to date. In this retrospective approach, 40 patients with OCD (23 females/17 males; 39.4 [10.1] years old in average; with scores on the Yale-Brown Obsessive-Compulsive Scale [Y-BOCS] of 19 [9.3]) were given an author-developed questionnaire. Twenty-three patients reported first changes before having reached the age of 20 years. Rather unspecific symptoms such as "anxiety" and "lacking self-trust" seem to have been more frequent as first signs of developing OCD. Further specific symptoms indicating OCD were "enhanced feeling of responsibility," "exact attention concerning details," "being eager for order and cleanness," "difficulties with decisions," and "repetitive controlling," but were less remembered. There was no significant relationship between these first changes and later OCD-related psychopathology as measured with the Y-BOCS, but there was a relationship with later depressive comorbidity (Hamilton Depression Rating Scale). This substantiates the view that OCD-similar to other psychiatric disorders such as schizophrenia and bipolar disorder-seems to be characterized by a psychopathologically less specific prodrome with rather depressive symptoms. However, this was a retrospective study with preliminary data, which has to be replicated prospectively with a larger sample.

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“…Next, depressive symptoms have been found to be a marker of poor course trajectories in SSD (Maurer et al, 2006). Häfner et al (2005a) found that patients suffering from more depressive symptoms in prodromal stages of illness had higher SSD symptom severity at the onset of first psychosis.…”

Section: Introductionmentioning

confidence: 99%