Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance

Manoach, Dara S.; Gollub, Randy L.; Benson, Etienne; Searl, Meghan; Goff, Donald C.; Halpern, Elkan P; Saper, Clifford B.; Rauch, Scott L.

doi:10.1016/s0006-3223(00)00227-4

Cited by 464 publications

(310 citation statements)

References 51 publications

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“…Significant activation was detected in a network of regions that was previously identified in several block design studies of the SIRP (Manoach et al, 1997(Manoach et al, , 1999(Manoach et al, , 2000 and that have been associated with WM performance in a range of tasks . The current event-related study provides a window on their behavioral affiliations.…”

Section: Discussionmentioning

confidence: 74%

“…In our previous block design study of the SIRP, basal ganglia and thalamic activation was seen in subjects with schizophrenia, but not in healthy subjects (Manoach et al, 2000). Several block-design neuroimaging studies of healthy subjects report basal ganglia and thalamic activation under conditions of increased WM demand (Barch et al, 1997;Callicott et al, 1999;Goldberg et al, 1998;.…”

Section: Discussionmentioning

confidence: 76%

“…We chose a numerical WM task that emphasizes maintenance (Sternberg Item Recognition Paradigm, SIRP) and adapted it to a rapid presentation, event-related fMRI task design. Regions that are reliably activated by the SIRP include the dorsolateral prefrontal cortex (DLPFC), intraparietal sulcus (IPS), lateral premotor cortex, supplementary motor area (SMA), and insula (Manoach et al, 1997(Manoach et al, , 1999(Manoach et al, , 2000. In this study we elucidated the temporal course of their participation.…”

Section: Introductionmentioning

confidence: 99%

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Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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This study describes the neural circuitry underlying temporally separated components of working memory (WM) performance-stimulus encoding, maintenance of information during a delay, and the response to a probe. While other studies have applied event-related fMRI to separate epochs of WM tasks, this study differs in that it employs a methodology that does not make any a priori assumptions about the shape of the hemodynamic response (HDR). This is important because no one model of the HDR is valid across the range of activated brain regions and stimulus types. Systematic modeling inaccuracies may lead to the misattribution of activity to adjacent events. Twelve healthy subjects performed a numerical version of the Sternberg Item Recognition Paradigm adapted for rapid presentation event-related fMRI. This paradigm emphasized maintenance rather than manipulative WM processes and used a subcapacity WM load. WM trials with different delay lengths were compared to fixation. The HDR of the entire WM trial for each trial type was estimated using a finite impulse response (FIR). Regional activity associated with the Encode, Delay, and Probe epochs was identified using contrasts that were based on the FIR estimates and by examining the HDRs. Each epoch was associated with a distinct but overlapping pattern of regional activity. Activation of the dorsolateral prefrontal cortex, thalamus, and basal ganglia was exclusively associated with the probe. This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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“…Specifically, working-memory studies during functional magnetic resonance imaging (fMRI) have shown that both chronic and first-episode never-medicated schizophrenia patients showed deficits in working memory performance associated with an increased or decreased activation (Callicott et al, 1998;Barch et al, 2001), or an increased spatial heterogeneity of dorsolateral prefrontal cortex activation (Manoach et al, 2000). The dorsolateral prefrontal cortex dysfunction in SZS during a working memory task has been associated with disorganization symptoms (Perlstein et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Paulus

Frank

Brown

et al. 2002

Neuropsychopharmacol

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Decision-making is a complex process that is important for everyday life. This study examined the effect of the degree of success, and outcome uncertainty, on decision-making and associated neural substrate activation in schizophrenia subjects (SZS) and normal comparison subjects (NCS). A total of 15 subjects with a diagnosis of schizophrenia and 15 age-and education-matched NCS participated in this study. These subjects completed the two-choice prediction task during functional magnetic resonance imaging. Decision-making characteristics and activation of neural substrates were obtained at 20, 50, or 80% error rate. Success and uncertainty influenced the behavioral characteristics on the two-choice prediction task, and the task-related activation in SZS and NCS. Neither success nor uncertainty differentially affected the behavioral characteristics of SZS relative to NCS during the two-choice prediction task. Nonetheless, there was a significant interaction between group and error rate in bilateral parietal cortex. The activation in NCS was the highest when the outcome was most uncertain. In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes.

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“…Many investigations have identified the neural mechanisms underlying the memory deficits observed in patients with schizophrenia (Leube et al., 2003; Manoach et al., 2000; Meyer‐Lindenberg et al., 2001). In particular, the role of the prefrontal cortex in working and episodic memory has been consistently emphasized (Achim & Lepage, 2005; Perlstein, Carter, Noll, & Cohen, 2001; Ragland et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Aberrant neural networks for the recognition memory of socially relevant information in patients with schizophrenia

Chun

Kim

et al. 2016

Brain and Behavior

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IntroductionPatients with schizophrenia exhibit several cognitive deficits, including memory impairment. Problems with recognition memory can hinder socially adaptive behavior. Previous investigations have suggested that altered activation of the frontotemporal area plays an important role in recognition memory impairment. However, the cerebral networks related to these deficits are not known. The aim of this study was to elucidate the brain networks required for recognizing socially relevant information in patients with schizophrenia performing an old–new recognition task.MethodsSixteen patients with schizophrenia and 16 controls participated in this study. First, the subjects performed the theme‐identification task during functional magnetic resonance imaging. In this task, pictures depicting social situations were presented with three words, and the subjects were asked to select the best theme word for each picture. The subjects then performed an old–new recognition task in which they were asked to discriminate whether the presented words were old or new. Task performance and neural responses in the old–new recognition task were compared between the subject groups. An independent component analysis of the functional connectivity was performed.ResultsThe patients with schizophrenia exhibited decreased discriminability and increased activation of the right superior temporal gyrus compared with the controls during correct responses. Furthermore, aberrant network activities were found in the frontopolar and language comprehension networks in the patients.ConclusionsThe functional connectivity analysis showed aberrant connectivity in the frontopolar and language comprehension networks in the patients with schizophrenia, and these aberrations possibly contribute to their low recognition performance and social dysfunction. These results suggest that the frontopolar and language comprehension networks are potential therapeutic targets in patients with schizophrenia.

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Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance

Cited by 464 publications

References 51 publications

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Aberrant neural networks for the recognition memory of socially relevant information in patients with schizophrenia

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