Schizophrenic patients with deficit syndrome have higher plasma homovanillic acid concentrations and ventricular enlargement

Nibuya, Masashi; Kanba, Shigenobu; Sekiya, Utako; Suzuki, Emiko; Matsuo, Yoko; Kinoshita, Norimitsu; Shintani, Futoshi; Yagi, Gohei

doi:10.1016/0006-3223(94)00216-p

Cited by 28 publications

(21 citation statements)

References 26 publications

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“…These findings were also reported by another study, which in addition to lower pHVA concentrations found higher plasma 3-methoxy-4-hydroxyphenylglycol concentrations in the DS compared with the NDS group even after controlling for demographic, clinical and therapeutic variables [142]. These findings were contradicted by Nibuya et al [143], who found higher pHVA concentrations in DS as compared to NDS subjects; the identification of patients with DS in this study has been criticized [8,142]. Two blind, placebo-controlled trials of MAO inhibitors also reported mixed results [144,145].…”

Section: Studies Of Associations Between Dopamine and Ds/nds Subtypesmentioning

confidence: 55%

Neurobiological background of negative symptoms

Galderisi

Merlotti

Mucci

2015

Eur Arch Psychiatry Clin Neurosci

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Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct. The literature in electronic databases as well as citations and major articles are reviewed with respect to the phenomenology, pathology, genetics and neurobiology of schizophrenia. We searched PubMed with the keywords "negative symptoms," "deficit schizophrenia," "persistent negative symptoms," "neurotransmissions," "neuroimaging" and "genetic." Additional articles were identified by manually checking the reference lists of the relevant publications. Publications in English were considered, and unpublished studies, conference abstracts and poster presentations were not included. Structural and functional imaging studies addressed the issue of neurobiological background of negative symptoms from several perspectives (considering them as a unitary construct, focusing on primary and/or persistent negative symptoms and, more recently, clustering them into factors), but produced discrepant findings. The examined studies provided evidence suggesting that even primary and persistent negative symptoms include different psychopathological constructs, probably reflecting the dysfunction of different neurobiological substrates. Furthermore, they suggest that complex alterations in multiple neurotransmitter systems and genetic variants might influence the expression of negative symptoms in schizophrenia. On the whole, the reviewed findings, representing the distillation of a large body of disparate data, suggest that further deconstruction of negative symptomatology into more elementary components is needed to gain insight into underlying neurobiological mechanisms.

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Section: Studies Of Associations Between Dopamine and Ds/nds Subtypesmentioning

confidence: 55%

Neurobiological background of negative symptoms

Galderisi

Merlotti

Mucci

2015

Eur Arch Psychiatry Clin Neurosci

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“…Indeed, Ribeyre et al [45] have reported lower plasma homovanillic acid (pHVA) levels and a lack of diurnal variations in deficit as compared with nondeficit patients. By contrast, Nibuya et al [46] have described an increase in pHVA levels in deficit as compared with nondcficit patients. However in Nibuya's study, most patients had been hospitalized for years and had higher levels of psychotic and dysphoric symptoms, which may have been responsible for a higher level of secondary negative symptoms and may, in turn, have confounded the biological data.…”

Section: Familial/sporadic Su Btype Smentioning

confidence: 83%

The Deficit Syndrome of Schizophrenia: Towards Heterogeneity

Thibaut

Petit²

1997

Psychopathology

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Since the turn of the century, psychiatrists have been concerned with both the unity and diversity of schizophrenia. From these early descriptions until now, many authors have attempted to delineate clinically meaningful subtypes within this disorder. In this connection, negative/positive subtyping has generated great interest. Carpenter and his team have emphasized the origin of the negative symptoms observed. They have proposed that primary enduring negative symptoms should be distinguished from transient negative symptoms resulting from treatment, depression or social deprivation and should be termed deficit symptoms. The validity of this subtyping is supported by clinical, biochemical or electrophysiological studies showing differences between deficit and nondeficit patients.

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“…One alternative would be to specifically study the morphological changes by CT in patients with a deficit syndrome [37], persistent symptoms [38] or with a refractory schizophrenia [39].…”

Section: Discussionmentioning

confidence: 99%

Correlates of Symptom Dimensions in Schizophrenia Obtained with the Spanish Version of the Manchester Scale

Tabarés¹,

Sanjuán²,

Gómez-Beneyto³

et al. 2000

Psychopathology

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In the last decade, a significant number of studies have been published which suggest a multifactorial psychopathological structure in schizophrenia. Seventy-eight acute and chronic schizophrenic patients diagnosed in accordance with DSM-III-R criteria were studied with the Manchester Scale, Premorbid Adjustment Scale, Family History-RDC Interview, Digit Span, Mini-Mental State and computerized tomography (CT). A factorial analysis of the symptoms as recorded with the Spanish version of the Manchester Scale was carried out. Three factors (‘positive’, ‘negative’ and ‘disorganization’) accounted for 79% of the total variance. Poor premorbid adjustment was associated with high scores for the ‘positive’ dimension. The ‘disorganization’ dimension was significantly associated with lower scores in the Mini-Mental and attention test than the rest. However, CT did not differentiate between these symptom dimensions. This study of a sample of mostly outpatients corroborates the hypothesis of three clinical dimensions in schizophrenia.

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Schizophrenic patients with deficit syndrome have higher plasma homovanillic acid concentrations and ventricular enlargement

Cited by 28 publications

References 26 publications

Neurobiological background of negative symptoms

Neurobiological background of negative symptoms

The Deficit Syndrome of Schizophrenia: Towards Heterogeneity

Correlates of Symptom Dimensions in Schizophrenia Obtained with the Spanish Version of the Manchester Scale

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