Schizophrenic individuals' cognitive functioning and performance in interpersonal interactions and skills training procedures

Bowen, Linda; Wallace, Charles J.; Glynn, Shirley M.; Nuechterlein, Keith H.; Lutzker, John R.; Kuehnel, Timothy G.

doi:10.1016/0022-3956(94)90012-4

Cited by 109 publications

(84 citation statements)

References 16 publications

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“…Continuous performance tests (CPTs) are widely used measures of deficits in sustained, focused attention and are prominent indices of neurocognitive deficits in schizophrenia (50)(51)(52)(53). Deficits in detection of target stimuli are evident in CPT simple simultaneous discrimination and successive discrimination (54)(55)(56)(57)(58)(59). CPTs without working memory burdens detect deficits (52,60), as do CPT versions with perceptual or working memory loads, which are more sensitive to subtle deficits (51,52).…”

Section: Neurocognitive Endophenotypesmentioning

confidence: 99%

Advances in endophenotyping schizophrenia

et al. 2008

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Section: Neurocognitive Endophenotypesmentioning

confidence: 99%

Advances in endophenotyping schizophrenia

et al. 2008

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“…Verbal memory and vigilance were found to be consistently associated with skill acquisition Mueser et al 1992;Bowen et al 1994;Corrigan et al 1994*), and the SPAN and the WCST were inconsistently associated with skill acquisition (Bowen et al 1994;Lysaker et al 19956). These studies used both inpatients and outpatients.…”

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confidence: 99%

“…hi the second group of studies, significant predictors of social problem solving included verbal memory (Bellack et al 1994;Corrigan et al 1994a); vigilance, assessed by the Continuous Performance Test (CPT; Nuechterlein 1991;Bowen et al 1994;Penn et al 1995); and early visual processing, assessed by the Span of Apprehension Task (SPAN; Asarnow and Nuechterlein 1992;Corrigan et al 1994a). Executive functioning, assessed by the Wisconsin Card Sorting Test (WCST; Heaton 1981), was not found to be significantly associated with social problem solving (Corrigan et al 1994a;Perm et al 1995).…”

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Neurocognitive and Social Functioning in Schizophrenia

Addington

1999

Schizophrenia Bulletin

284

154

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This cross-sectional study examined the relationships between neurocognitive and social functioning in a sample of 80 outpatients with DSM-III-R schizophrenia. The neurocognitive battery included measures of verbal ability, verbal memory, visual memory, executive functioning, visual-spatial organization, vigilance, and early information processing. Positive and negative symptoms were assessed with the Positive and Negative Syndrome Scale. A range of social behaviors were assessed using the Social Functioning Scale (SFS), the Quality of Life Scale (QLS), and a videobased test, the Assessment of Interpersonal ProblemSolving Skills (AIPSS). Social functioning as assessed by the SFS was unrelated to neurocognitive functioning. Poor cognitive flexibility was associated with low scores on the QLS and the AIPSS. Verbal ability and verbal memory were also significantly associated with the AIPSS. Visual-spatial ability and vigilance were associated with the sending skills subscale of the AIPSS. In this study, which used a wide range of neurocognitive tests and measures of community functioning and social problem solving, results support earlier research that suggests an association between certain aspects of neurocognitive functioning and social functioning.

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“…There is considerable evidence that neuropsychological impairment is associated with poor functioning in people with schizophrenia (Bowen et al 1994;Green et al 2000;Kern et al 1992;Lysaker et al 1995;McKee et al 1997;Penn et al 1995). Neuropsychological impairment is also a strong predictor of poor outcome in psychosocial interventions that target functional impairments in this population.…”

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Neuropsychological predictors of functional outcome in Cognitive Behavioral Social Skills Training for older people with schizophrenia

Granholm

McQuaid

Link

et al. 2008

Schizophrenia Research

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Cognitive Behavioral Social Skills Training (CBSST) is a 24-session weekly group therapy intervention to improve functioning in people with schizophrenia. In our prior randomized clinical trial comparing treatment as usual (TAU) with TAU plus group CBSST (Granholm et al. 2005), participants with schizophrenia in CBSST showed significantly better functional outcome than participants in TAU. The present study was a secondary analysis of neuropsychological predictors of functional outcome in our prior CBSST trial. We examined (1) whether neuropsychological impairment at baseline moderated functional outcome in CBSST relative to TAU, and (2) whether improvement in neuropsychological abilities mediated improvement in functional outcome in CBSST. Attention, verbal learning/memory, speed of processing, and executive functions were assessed at baseline, end of treatment, and 12-month follow-up. Greater severity of neuropsychological impairment at baseline predicted poorer functional outcome for both treatment groups (nonspecific predictor), but the interaction between severity of neuropsychological impairment and treatment group was not significant (no moderation). Effect sizes for the difference between treatment groups on functional outcome measures at 12-month follow-up were similar for participants with relatively mild (d=.44-.64) and severe (d=.29-.60) neuropsychological impairment. Results also did not support the hypothesis that improvement in neuropsychological abilities mediated improvement in functioning in CBSST. Adding CBSST to standard pharmacologic care, therefore, improved functioning relative to standard care alone, even for participants with severe neuropsychological impairment, and this improvement in functioning was not related to improvement in neuropsychological abilities in CBSST. KeywordsSchizophrenia; cognitive behavior therapy; social skills training; neuropsychological impairment; functioning Please address all correspondence to: Eric Granholm, Ph.D., VA San Diego Healthcare System (116B), 3350 La Jolla Village Drive, San Diego, CA 92161, Phone: (858) 552-8585 x 7768, FAX: (858) 642-6416, Email: egranholm@ucsd.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptThere is considerable evidence that neuropsychological impairment is associated with poor functioning in people with schizophrenia (Bowen et al. 1994;Green et al. 2000;Kern et al. 1992;Lysaker et al. 1995;McKee et al. 1997;Penn et al. 1995). Neuropsychological impairment is also a strong predictor ...

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Schizophrenic individuals' cognitive functioning and performance in interpersonal interactions and skills training procedures

Cited by 109 publications

References 16 publications

Advances in endophenotyping schizophrenia

Advances in endophenotyping schizophrenia

Neurocognitive and Social Functioning in Schizophrenia

Neuropsychological predictors of functional outcome in Cognitive Behavioral Social Skills Training for older people with schizophrenia

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