Schizophrenia-relevant behaviours of female mice overexpressing neuregulin 1 type III

Olaya, Juan C; Heusner, Carrie L.; Matsumoto, Mitsuyuki; Weickert, Cynthia Shannon; Karl, Tim

doi:10.1016/j.bbr.2018.03.026

Cited by 23 publications

(24 citation statements)

References 65 publications

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“…32 One day before testing, A/JArc mice were habituated to the test area for 10 minutes. 32 One day before testing, A/JArc mice were habituated to the test area for 10 minutes.…”

Section: Social Interaction (Cohort 2-pnd120)mentioning

confidence: 99%

“…The apparatus was Y-shaped (three arms 7.5 cm wide, 22 cm long, 19 cm high-at 120 to each other) with external visual cues placed on the wall above the apparatus similar to that previously published. 32 In the first trial, mice were placed in the centre of the Y-maze with one arm closed off and allowed to explore for 10 minutes. After 30 minutes, mice were returned to the apparatus with all three arms open and allowed to explore for a further 10 minutes.…”

Section: Y-maze (Cohort 1-pnd80)mentioning

confidence: 99%

“…36 The test was carried out as previously published. 32 The FC task occurred over 3 days. On the first day (conditioning trial), mice were placed in a test chamber (NIR-022MD, ENV-005FPU-M, MED Associates Inc., St Albans, VT) with a vanilla scent (Queen imitation vanilla essence) cue for 7 minutes.…”

Section: Fear Conditioning (Cohort 1-pnd96)mentioning

confidence: 99%

“…The social interaction (SI) test was used to measure spontaneous social behaviour between a pair of unfamiliar mice as previously published. 32 One day before testing, A/JArc mice were habituated to the test area for 10 minutes. Test animals were placed inside a grey plastic…”

Section: Social Interaction (Cohort 2-pnd120)mentioning

confidence: 99%

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Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

Kreilaus

Guerra

Masanetz

et al. 2019

Genes Brain and Behavior

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Amyotrophic lateral sclerosis (ALS) involves the rapid degeneration of upper and lower motor neurons leading to weakening and paralysis of voluntary movements. Mutations in copper‐zinc superoxide dismutase 1 (SOD1) are a known genetic cause of ALS, and the SOD1 G93A mouse has been used extensively to investigate molecular mechanisms in ALS. In recent years, evidence suggests that ALS and frontotemporal dementia form a spectrum disorder ranging from motor to cognitive dysfunctions. Thus, we tested male and female SOD1 G93A mice for the first time before the onset of debilitating motor impairments in behavioural domains relevant to both ALS and frontotemporal dementia. SOD1 G93A males displayed reduced locomotion, exploration and increased anxiety‐like behaviours compared with control males. Intermediate‐term spatial memory was impaired in SOD1 G93A females, whereas long‐term spatial memory deficits as well as lower acoustic startle response, and prepulse inhibition were identified in SOD1 G93A mice of both sexes compared with respective controls. Interestingly, SOD1 G93A males exhibited an increased conditioned cue freezing response. Nosing behaviours were also elevated in both male and female SOD1 G93A when assessed in social paradigms. In conclusion, SOD1 G93A mice exhibit a variety of sex‐specific behavioural deficits beyond motor impairments supporting the notion of an ALS‐frontotemporal spectrum disorder. Thus, SOD1 G93A mice may represent a useful model to test the efficacy of therapeutic interventions on clinical symptoms in addition to declining motor abilities.

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“…32 One day before testing, A/JArc mice were habituated to the test area for 10 minutes. 32 One day before testing, A/JArc mice were habituated to the test area for 10 minutes.…”

Section: Social Interaction (Cohort 2-pnd120)mentioning

confidence: 99%

Section: Y-maze (Cohort 1-pnd80)mentioning

confidence: 99%

Section: Fear Conditioning (Cohort 1-pnd96)mentioning

confidence: 99%

Section: Social Interaction (Cohort 2-pnd120)mentioning

confidence: 99%

See 2 more Smart Citations

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

Kreilaus

Guerra

Masanetz

et al. 2019

Genes Brain and Behavior

Self Cite

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“…They showed that NRG1-IV/NSE-tTA mice display disturbed behaviors relevant to SZ, such as impaired sensorimotor gating, discrimination memory, and social behaviors. Olaya et al [133] generated transgenic mice with forebrain-driven Nrg1 III overexpression (Nrg1 III tg) and stated that these mice exhibited several SZ-relevant behaviors including social and cognitive deficits as well as impaired sensorimotor gating. Finally, there are also reports about the role of neuregulin-3 in SZ [134] which may also be a base of animal genetic models.…”

Section: Genetic Animal Models Of Szmentioning

confidence: 99%

In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia

et al. 2020

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Schizophrenia (SZ) is a complex psychiatric disorder characterized by positive, negative, and cognitive symptoms, and is not satisfactorily treated by current antipsychotics. Progress in understanding the basic pathomechanism of the disease has been hampered by the lack of appropriate models. In order to develop modern drugs against SZ, efficient methods to study them in in vitro and in vivo models of this disease are required. In this review a short presentation of current hypotheses and concepts of SZ is followed by a description of current progress in the field of SZ experimental models. A critical discussion of advantages and limitations of in vitro models and pharmacological, genetic, and neurodevelopmental in vivo models for positive, negative, and cognitive symptoms of the disease is provided. In particular, this review concerns the important issue of how cellular and animal systems can help to meet the challenges of modeling the disease, which fully manifests only in humans, as experimental studies of SZ in humans are limited. Next, it is emphasized that novel clinical candidates should be evaluated in animal models for treatment-resistant SZ. In conclusion, the plurality of available in vitro and in vivo models is a consequence of the complex nature of SZ, and there are extensive possibilities for their integration. Future development of more efficient antipsychotics reflecting the pleiotropy of symptoms in SZ requires the incorporation of various models into one uniting model of the multifactorial disorder and use of this model for the evaluation of new drugs.

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Application of animal experimental models in the research of schizophrenia

Wang

Zhao

et al. 2021

American J of Med Genetics Pt B

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Schizophrenia is a relatively common but serious mental illness that results in a heavy burden to patients, their families, and society. The disease can be triggered by multiple factors, while the specific pathogenesis remains unclear. The development of effective therapeutic drugs for schizophrenia relies on a comprehensive understanding of the basic biology and pathophysiology of the disease. Therefore, effective animal experimental models play a vital role in the study of schizophrenia. Based on different molecular mechanisms and modeling methods, the currently used experimental animal experimental models of schizophrenia can be divided into four categories that can better simulate the clinical symptoms and the interplay between susceptible genes and the environment: neurodevelopmental, drug‐induced, genetic‐engineering, and genetic‐environmental interaction of animal experimental models. Each of these categories contains multiple subtypes, which has its own advantages and disadvantages and therefore requires careful selection in a research application. The emergence and utilization of these models are promising in the prediction of the risk of schizophrenia at the molecular level, which will shed light on effective and targeted treatment at the genetic level.

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Schizophrenia-relevant behaviours of female mice overexpressing neuregulin 1 type III

Cited by 23 publications

References 65 publications

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia

Application of animal experimental models in the research of schizophrenia

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Schizophrenia-relevant behaviours of female mice overexpressing neuregulin 1 type III

Cited by 23 publications

References 65 publications

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia

Application of animal experimental models in the research of schizophrenia

Contact Info

Product

Resources

About

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1^G93A) mouse model of amyotrophic lateral sclerosis include sex‐dependent phenotypes