Schizophrenia-Related Disability in China: Prevalence, Gender, and Geographic Location

Liu, Tianli; Zhang, Lei; Pang, Lihua; Li, Ning; Chen, Gong; Zheng, Xiaoying

doi:10.1176/appi.ps.201400032

Cited by 33 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study the magnitude of disability was 41.7% (95%CI: 36.9, 46.4). This nding was in line with the studies conducted in China41% (25), and other research conducted in China (37%, 44% in men and women respectively(30), in India 41% (31). On the other hand the ndings of this study was lower than the previous studies undertaken in India 83% (8), Ranchi institute of Neuro-psychiatry and Allied science Ranchi, 88%(32), Thirthahalli Taluk of Shimoga District, Karnataka 62% (26), in Spain 67.6% (33).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Magnitude and associated factors of disability in patients with schizophrenia attending Gondar, Felegehiwot and Debretabor hospitals Amhara North West Ethiopia 2019: Institutional based cross-sectional study.

Mihretie

Legas

Asnakew

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Schizophrenia is a severe, chronic and disabling mental illness that places significant burden not only on the individuals, but also on their families and society. As per our knowledge there is no study conducted on prevalence and associated factors of disability in schizophrenic patients in Ethiopia. Their fore, this study aimed to assess the magnitude and associated factors of disability in patients with schizophrenia attending Gondar, Felegehiwot and Debretabor hospital, North West Ethiopia 2019Methods An Institutional -based cross-sectional study was conducted among schizophrenic patients attending Gondar, Felegehiwot and Debretabor hospitals Amhara Ethiopia. A total of 420 participants were included in the study. Data were collected by face to face interview using systematic random sampling method. Disability was measured using World Health Organization Disability Assessment Scale 2.0. Coded variables were entered into Epi data V.4.4.2 and exported to SPSS V.24 for analysis. Bivariate and multivariate logistic regressions with OR and 95% CI were employed. The level of significance of association was determined at p-value < 0.05.Result A total of 420 participants were interviewed, with a response rate of 99.3%. The magnitude of disability in this study was 41.7% (95%CI: 36.9, 46.4). Current use of alcohol (AOR = 2.47, 95CI;1.36,4.48), being jobless(AOR = 3.27, 95CI; 1.80, 5.93)., had negative symptoms (AOR = 13.05,95CI,7.58,22.45), had 5 and more years of illness(AOR = 2.75,95CI;1.29,5.86) and had 5 and more years of untreated psychosis (AOR = 3.78,95CI, 1.85,7.75) were predictors of disability.Conclusion and recommendation: The magnitude of disability in this study was high. Avoidance of alcohol usage, early initiation of treatment, creating job opportunity and giving special emphasis for patients having negative symptoms is recommended.

show abstract

Section: Discussionsupporting

confidence: 92%

“…A research done in India among One hundred participants diagnosed to be suffering from schizophrenia as per DSM IV or ICD-10, 83% of them found with mild to moderate disability (25).…”

Section: Introductionmentioning

confidence: 99%

Magnitude and associated factors of disability in patients with schizophrenia attending Gondar, Felegehiwot and Debretabor hospitals Amhara North West Ethiopia 2019: Institutional based cross-sectional study.

Mihretie

Legas

Asnakew

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The independent variable was education, which was classified into 3 categories: primary school and below, junior high school and senior high school and above. According to previous findings [25,26], we considered demographic characteristics and socioeconomic conditions as potential confounders.…”

Section: Methodsmentioning

confidence: 99%

Gender difference in the association between education and schizophrenia in Chinese adults

Luo

Pang

Zhao

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Improving education level was evidenced to decrease the risk of schizophrenia, but whether this strength of education role depends on gender is not. This study aimed to investigate whether there was gender difference in the association between education and schizophrenia in Chinese adults. Methods: Data were obtained from the Second China National Sample Survey on Disability in 2006, including 1,909,205 participants aged 18 years or older. Schizophrenia was ascertained according to the International Statistical Classification of Diseases, Tenth Revision. Logistics regression models were fitted to examine the combined effect of gender and education on schizophrenia. Results: The lifetime prevalence of schizophrenia in female groups was higher than in male groups, with 0.44% (95% CI : 0.42%- 0.45%) and 0.36% (95% CI : 0.35%- 0.37%), respectively. Compared with schizophrenia male patients, more females with schizophrenia experienced severe or extreme difficulty in understanding and communicating. However, more males with schizophrenia suffered from severe or extreme difficulty in the function of daily activities. The combined effect of education and schizophrenia was statistically significant, indicating that, as the level of education increased, schizophrenia risk of females decreased faster than the risk of males. Conclusions: This study showed that additional years of education associated with lower risk of schizophrenia, and this association was stronger in females than in males. As education elevated, the risk of schizophrenia decreased more for women than for men. The findings indicate that improving education level may have an effect on reducing the gender disparities in mental health of China. Actions to prevent schizophrenia and address its gender disparities will require attention to the improving educational opportunities.

show abstract

“…The lifetime risk of SCZ is approximately 1% across the world (Mayilyan, Weinberger & Sim, 2008), and the lifetime prevalence of adults in China was 0.6% (Huang et al, 2019). SCZ has a marked impact on the life quality and accounts for approximately 2.8% of the global burden of diseases reported by the World Health Organization in 2001, and the prevalence of SCZ disability was 0.41% in China (Liu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Association of the CACNA2D2 gene with schizophrenia in Chinese Han population

Zhou

Bai

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background Schizophrenia (SCZ) is a severely complex psychiatric disorder in which ~80% can be explained by genetic factors. Single nucleotide polymorphisms (SNPs) in calcium channel genes are potential genetic risk factors for a spectrum of psychiatric disorders including SCZ. This study evaluated the association between SNPs in the voltage-gated calcium channel auxiliary subunit alpha2delta 2 gene (CACNA2D2) and SCZ in the Han Chinese population of Northeast China. Methods A total of 761 SCZ patients and 775 healthy controls were involved in this case-control study. Three SNPs (rs3806706, rs45536634 and rs12496815) of CACNA2D2 were genotyped by the MALDI-TOF-MS technology. Genotype distribution and allele frequency differences between cases and controls were tested by Chi-square (χ2) in males and females respectively using SPSS 24.0 software. Linkage disequilibrium and haplotype analyses were conducted using Haploview4.2. The false discovery rate correction was utilized to control for Type I error by R3.2.3. Results There was a significant difference in allele frequencies (χ2 = 9.545, Padj = 0.006) and genotype distributions (χ2 = 9.275, Padj = 0.006) of rs45536634 between female SCZ patients and female healthy controls after adjusting for multiple comparisons. Minor allele A (OR = 1.871, 95% CI [1.251–2.798]) and genotype GA + AA (OR = 1.931, 95% CI [1.259–2.963]) were associated with an increased risk of SCZ. Subjects with haplotype AG consisting of rs45536634 and rs12496815 alleles had a higher risk of SCZ (OR = 1.91, 95% CI [1.26–2.90]) compared those with other haplotypes. Conclusions This study provides evidence that CACNA2D2 polymorphisms may influence the susceptibility to SCZ in Han Chinese women.

show abstract

Schizophrenia-Related Disability in China: Prevalence, Gender, and Geographic Location

Abstract: Socially disadvantaged rural women were disproportionately affected by schizophrenia-related disability. Limited access to health services may have contributed to the increased disease burden among rural women.

Cited by 33 publications

References 17 publications

Magnitude and associated factors of disability in patients with schizophrenia attending Gondar, Felegehiwot and Debretabor hospitals Amhara North West Ethiopia 2019: Institutional based cross-sectional study.

Magnitude and associated factors of disability in patients with schizophrenia attending Gondar, Felegehiwot and Debretabor hospitals Amhara North West Ethiopia 2019: Institutional based cross-sectional study.

Gender difference in the association between education and schizophrenia in Chinese adults

Association of the CACNA2D2 gene with schizophrenia in Chinese Han population

Contact Info

Product

Resources

About