Schizophrenia predisposition gene Unc-51-like kinase 4 for the improvement of cerebral ischemia/reperfusion injury

Luo, Wen; Yang, Junqing

doi:10.1007/s11033-021-07108-z

Cited by 2 publications

(4 citation statements)

References 41 publications

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“…The marker OAR19_14805437.1 associated with face wool score was within unc-51 like Kinase 4 ( ULK4 ). Overexpression of the gene ULK4 has been shown to inhibit apoptosis ( Luo and Yang 2022 ). Fiber producing follicles undergo a cycle including active growth, apoptosis-driven involution (catagen), shedding and resting in humans and mice ( Botchkareva et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

“… Genes with biological functions relevant to follicular growth. Significant SNPs identified in GWAS are located within or near genes with known biological roles relevant to skin and follicular growth, including ULK4 ( Luo and Yang 2022 ), U6 spliceosomal RNA ( Hilcenko et al, 2013 ), 60S ribosomal protein L17-like ( Yang et al, 2016 ), ribosomal protein S19 ( Kuramoto et al, 2005 ), ABCC8 ( Shorter et al, 2008 ) and WT1 ( Wagner et al, 2008 ). The significant SNPs within 60S ribosomal protein L17-like and ABCC8 had predicted TFBS score differences between reference and alternate alleles.…”

Section: Discussionmentioning

confidence: 99%

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Genetic association of wool quality characteristics in United States Rambouillet sheep

et al. 2023

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Introduction: Fine wool production is an important source of revenue, accounting for up to 13% of total revenue in extensively managed wool sheep production systems of the United States. The Rambouillet are a predominant breed that excels in wool quality characteristics. Understanding the genetic basis of wool quality characteristics would aid in the development of genomic breeding strategies to facilitate genetic improvement.Methods: Wool characteristics and DNA were collected for rams enrolled in the North Dakota State University and University of Wyoming annual central performance ram tests over a three-year period (2019–2021, N = 313). The relationships of wool quality characteristics including grease fleece weight adjusted 365 days (wt. 365 adj.), clean fleece wt. 365 adj., staple length 365 adj., average fiber diameter, face wool cover, amount of skin wrinkles and belly wool were evaluated through genome-wide association studies (GWAS), Pearson correlation and ANOVA.Results: The GWAS identified four genome-wide significant genetic markers (p-value <1.19e-06) and five chromosome-wide significant markers (p-value <1.13e-05) on chromosomes 1, 2, 4, 15, and 19. Significant markers were associated with genes notable for relevant wool biological functions, including the gene ABCC8 which codes for SUR1, an ATP-sensitive potassium channel known to affect hair growth and 60S ribosomal protein L17-like, previously found to be expressed during follicle formation. The strongest Pearson correlation coefficients were identified between clean fleece wt. 365 adj. and grease fleece wt. 365 adj. (r = 0.83) and between clean fleece wt. 365 adj. and staple length 365 adj. (r = 0.53). Additionally, clean fleece wt. 365 adj. was correlated with final body weight (r = 0.35) and scrotal circumference (r = 0.16). Staple length 365 adj. (p-value = 5e-04), average fiber diameter (p-value = .0053) and clean fleece wt. 365 adj. (p-value = .014) were significantly associated with belly wool score.Discussion: The results of this study provide important insight into the relationships between wool quality characteristics and report specific markers that Rambouillet sheep producers may use to help inform selection and breeding decisions for improved wool quality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic association of wool quality characteristics in United States Rambouillet sheep

et al. 2023

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“…With advancements in scientific research, in order to better elucidate the mechanism, the research needs to be done not only in living animal (in vivo), but also using cell culture in−vitro experiments for verification. The culture of neurons has enabled great convenience in the study of neuron growth, development, and pathophysiology mechanisms in vitro, which is helpful for medical staff and researchers to gain further understanding of a variety of neurological diseases, such as Alzheimer's disease, Parkinson's disease, neonatal hypoxic–ischemic encephalopathy, stroke, cerebral ischemia/reperfusion injury, and so on 1–5 . Primary culture of neurons can fulfill such demands.…”

Section: Introductionmentioning

confidence: 99%

“…The culture of neurons has enabled great convenience in the study of neuron growth, development, and pathophysiology mechanisms in vitro, which is helpful for medical staff and researchers to gain further understanding of a variety of neurological diseases, such as Alzheimer's disease, Parkinson's disease, neonatal hypoxic–ischemic encephalopathy, stroke, cerebral ischemia/reperfusion injury, and so on. 1 , 2 , 3 , 4 , 5 Primary culture of neurons can fulfill such demands. Primary cultured neurons are very similar to in vivo neurons, the experimental conditions are stable and controllable, and the experimental environment is relatively simple.…”

Section: Introductionmentioning

confidence: 99%

Differences between cultured cortical neurons by trypsin and papain digestion

Xiao

et al. 2022

Ibrain

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The objective of this study was to compare the efficiency of trypsin and papain in neuronal digestion and determine which enzyme is more efficient. Cortical tissues were obtained from Sprague-Dawley (SD) rats. According to the different digestive enzymes, the samples were divided into the trypsin group and the papain group. After being digested by each of the two enzymes, cortical neurons were collected from the samples. Then, the morphology of the cortical neurons was determined. Moreover, the cortical neurons were transfected with the negative control (NC) lentivirus. The transfection efficiency and morphology were determined and compared. Compared with the papain

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Schizophrenia predisposition gene Unc-51-like kinase 4 for the improvement of cerebral ischemia/reperfusion injury

Cited by 2 publications

References 41 publications

Genetic association of wool quality characteristics in United States Rambouillet sheep

Genetic association of wool quality characteristics in United States Rambouillet sheep

Differences between cultured cortical neurons by trypsin and papain digestion

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