Schizophrenia-Like Psychosis Presented in a Patient With a Temporal Lobe Tumor: A Case Report

Romero-Luna, Gerardo; Mejía-Pérez, Sonia Iliana; Ramírez-Cruz, Jacqueline; Aguilar-Hidalgo, Keren Magaly; Ocampo-Díaz, Karla Marisol; Moscardini-Martelli, Júlia; Ramírez-Stubbe, Viviana; Santellán-Hernández, José Omar

doi:10.7759/cureus.29034

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In the literature, other cases in which cancer and psychotic disorders were diagnosed together have also been reported. A 46-year-old male patient with complaints of hearing voices, incoherent thinking and then committing murder was diagnosed with a schizophrenia-like psychosis due to a mass in the temporal lobe [ 10 ]. The primary cancer in this case was brain cancer and the behavior differs from our case in this respect.…”

Section: Discussionmentioning

confidence: 99%

The Emergence of a Psychotic Disorder With a Diagnosis of Breast Cancer Metastasized to the Brain: A Case Report

Taşar Yıldırım,

Yıldız

2023

Cureus

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It is known that psychotic patients have a reduced ability to evaluate reality and self-care. However, no case has been reported in which a breast lump was misdiagnosed as an insect bite and neglected, and a diagnosis of psychotic disorder led to metastatic breast cancer. A 44-year-old woman diagnosed with invasive breast cancer with brain metastasis became unresponsive with little reaction to verbal communication as a result of successive life-threatening events. After her presentation to the emergency department, she was diagnosed with metastatic breast cancer as a result of detailed examinations. The patient, who did not have any psychiatric illness or alcohol or drug addiction in her medical history, was so insensitive to herself and her environment that she could not notice the large mass in her breast and the bad odors coming from her. According to these findings, the patient was suspected to have a psychotic disorder accompanied by substupor, and olanzapine 2.5 mg/day was administered. If the diagnosis of psychotic disorder is not recognized and treated, the highly visible breast lump may be misperceived and cancer treatment may be delayed, thus the cancer may progress. Early recognition and treatment of mental disorders affect the mortality and morbidity of patients.

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Section: Discussionmentioning

confidence: 99%

The Emergence of a Psychotic Disorder With a Diagnosis of Breast Cancer Metastasized to the Brain: A Case Report

Taşar Yıldırım,

Yıldız

2023

Cureus

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“…A recent study conducted using iPSC reported altered Wnt-1 signaling activity, a potent inducer of cell cycle in association with abnormal NPC proliferation and imbalanced differentiation of excitatory and inhibitory neurons leading to neuronal circuit miswiring as the developmental origin of schizophrenia [173]. Moreover, subjects with brain metastatic conditions, a state with the malignant proliferation of neuroblasts and glial cells have been reported to display hallucinations [174]. Therefore.…”

Section: Reactive Neuroblastosis As An Underlying Mechanism Of Halluc...mentioning

confidence: 99%

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblostosis as a Possible Pathocellular Mechanism of Hallucination

Babu Deva Irakkam,

Joseph,

Kandasamy

2023

Preprint

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Schizophrenia is a spectrum of neuropsychiatric deformities, characterized by hallucination, delusion, mood disorders, speech pathology, and neurocognitive deficits. Among various clinical manifestations, hallucination has been recognized as a core psychotic symptom that occurs more frequently in schizophrenia. A significant number of subjects with neurocognitive disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and other neurological diseases like stroke and epileptic seizure also experience hallucinations. While aberrant neurotransmission has been linked to the neuropathogenic events of schizophrenia, the specific cellular mechanism contributing to hallucinations remains ambiguous. Neurodegeneration in the hippocampus of the brain has been identified as a predominant pathogenic determinant of dementia. While the scientific proof for the neurodegeneration in schizophrenia is limited, the occurrence of dementia in schizophrenia has become increasingly evident. To note, both neurodegenerative, neurodevelopmental, and neuropsychiatric disorders display impaired neurogenesis in the brain. Impaired neurogenesis in the hippocampus has been linked to dementia and mood disorders. Notably, the early phase of many neurodegenerative disorders has been characterized by reactive neuroblostosis and aberrant cell cycle activation in mature neurons leading to the fluctuation in neurogenic processes leading to abnormal synaptogenesis and neurotransmission in the brain. Thus, this article emphasizes a hypothesis that aberrant neurogenic processes could be an underlying mechanism of hallucination in schizophrenia and other neurological diseases.

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Neuropsychiatric Manifestations of a Frontal Lobe Meningioma: A Case Report

Bokhari,

Elnoor,

Al Mansour

et al. 2024

Cureus

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Schizophrenia-Like Psychosis Presented in a Patient With a Temporal Lobe Tumor: A Case Report

Cited by 3 publications

References 26 publications

The Emergence of a Psychotic Disorder With a Diagnosis of Breast Cancer Metastasized to the Brain: A Case Report

The Emergence of a Psychotic Disorder With a Diagnosis of Breast Cancer Metastasized to the Brain: A Case Report

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblostosis as a Possible Pathocellular Mechanism of Hallucination

Neuropsychiatric Manifestations of a Frontal Lobe Meningioma: A Case Report

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