Schizophrenia-like psychoses of epilepsy

Tadokoro, Yukari; Kanemoto, Kousuke

doi:10.3805/eands.5.1

Cited by 2 publications

(2 citation statements)

References 58 publications

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“…However, while PIP constitutes a rather homogenous clinical entity, IIP is apparently quite heterogeneous. Most often, IIP is subdivided into chronic and acute interictal types, with the latter comprising also patients with alternative psychosis [Tadokoro and Kanemoto, 2012; Trimble, 1991].…”

Section: Discussionmentioning

confidence: 99%

Psychotic illness in patients with epilepsy

Kanemoto

Tadokoro

Oshima

2012

Ther Adv Neurol Disord

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Apart from the rather rare ictal psychotic events, such as non-convulsive status epilepticus, modern epileptic psychoses have been categorized into three main types; chronic and acute interictal psychoses (IIPs) and postictal psychosis (PIP). Together, they comprise 95% of psychoses in patients with epilepsy (PWE). Four major questions, that is, "Is psychosis in PWE a direct consequence of epilepsy or schizophrenia induced by epilepsy?", "Is psychosis in PWE homogeneous or heterogeneous?", "Does psychosis in PWE have symptomatological differences from schizophrenia and related disorders?", "Is psychosis in PWE uniquely associated with temporal lobe epilepsy (TLE)?" are tried to be answered in this review with relevant case presentations. In the final section, we propose a tentative classification of psychotic illness in PWE, with special attention to those who have undergone epilepsy surgery. Psychotic disorders in PWE are often overlooked, mistreated, and consequently lingering on needlessly. While early diagnosis is unanimously supported as a first step to avoid this delay, necessity of switching from antiepileptic drugs with supposedly adverse psychotopic effects. to others is more controversial. To elucidate the riddle of alternative psychosis, we need badly further reliable data.

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Section: Discussionmentioning

confidence: 99%

Psychotic illness in patients with epilepsy

Kanemoto

Tadokoro

Oshima

2012

Ther Adv Neurol Disord

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“…421 Previous studies have identified talin, a cytoskeletal-associated protein, as a cytoplasmic activator for integrin. 376,[422][423][424] MD simulations have highlighted the role of the lipid bilayer in regulating the specific interhelical interactions between α and β subunits of integrins. 426 Leveraging the power of CG simulations, stability dynamics of αLβ2 and αIIβ integrins was studied in model membranes.…”

Section: G Protein-coupled Receptors (Gpcrs)-allmentioning

confidence: 99%

Characterization of Lipid–Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation

et al. 2019

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The cellular membrane constitutes one of the most fundamental compartments of a living cell, where key processes such as selective transport of material and exchange of information between the cell and its environment are mediated by proteins that are closely associated with the membrane. The heterogeneity of lipid composition of biological membranes and the effect of lipid molecules on the structure, dynamics, and function of membrane proteins are now widely recognized. Characterization of these functionally important lipid-protein interactions with experimental techniques is however still prohibitively challenging. Molecular dynamics (MD) simulations offer a powerful complementary approach with sufficient temporal and spatial resolutions to gain atomic-level structural information and energetics on lipid-protein interactions. In this review, we aim to provide a broad survey of MD simulations focusing on exploring lipidprotein interactions and characterizing lipid-modulated protein structure and dynamics that have been successful in providing novel insight into the mechanism of membrane protein function.

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Schizophrenia-like psychoses of epilepsy

Cited by 2 publications

References 58 publications

Psychotic illness in patients with epilepsy

Psychotic illness in patients with epilepsy

Characterization of Lipid–Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation

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