Schizophrenia-like disorder in Wilson's disease

Abstract

Wilson's (Wilson–Konovalov) disease (WD) is a chronic progressive disease resulting from impaired body copper metabolism with damages to target organs (liver, brain, and kidneys). The paper describes a clinical case of organic delusional (schizophrenia-like) disorder in a patient with WD. The characteristic feature of its psychiatric onset in the patient is schizophrenia-like disorders in the absence of neurological and gastroenterological symptoms. Because of this onset of WD, patients have not received specific treatment for a long time (frequently before the appearance of the Kayser–Fleischer rings or the occurrence of cirrhosis). Thus, the diagnostic search should include WD in young patients with a primary psychotic episode. The search for early effective methods for WD verification is of interest for further investigations.

Sociological research of the men’s androgenic alopecia problem

“…Clinical manifestations of some skin diseases, for example, the symptom of itching, are the cause of negative behavioural changes in patients with dermatoses. As a result, it is dermatopathologies among somatic diseases that are often accompanied by psychological disorders [2]. On the other hand, the functioning of the skin, as the largest organ of the human body, is closely related and regulated by the central nervous system.…”

“…Today, there is no unified classification of psychodermatological disorders, but the following are most often distinguished: psychophysiological (syn. psychosomatic) disorders; mental disorders with dermato-logical symptoms (primary mental disorders); dermatological disorders with psychiatric symptoms (secondary mental disorders) [2]. In the case of diseases that traditionally belong to psychophysiological ones, both components, both psychosomatic and somatopsychic, are mainly expressed, since not only psycho-emotional stress leads to the emergence of pathology, but also the very fact of the presence of dermatosis causes psycho-emotional reactions in the patient.…”

“…Alopecia does not pose a threat to a person's physiological health and is a cosmetic defect. However, this disease is often accompanied by secondary mental disorders, such as adaptation disorders, depression, anxiety states, which significantly worsen the quality of life of people, especially young people, and women [2,7,10].…”