Schizophrenia After Prenatal Famine

Süsser, Ezra; Neugebauer, Richard; Hoek, Hans W.; Brown, Alan S.; Shang, Lin; Labovitz, Daniel L.; Gorman, Jack M.

doi:10.1001/archpsyc.1996.01830010027005

Cited by 671 publications

(356 citation statements)

References 32 publications

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“…In many instances, such long-term effects are associated with undemutrition early in pregnancy, because of the increased sensitivity of the cell to undemutrition during periods of cell division compared with periods of cell growth (26,27). In this context, it is of interest to note that the twofold increase in the risk of schizophrenia and schizoid personality disorder among males and females who were prenataliy exposed to the Dutch famine is associated with intrauterine exposure in early pregnancy and not in late pregnancy (28,29). In humans, no decrease in birth weights is seen when intrauterine undemutrition is limited to early pregnancy (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Offspring Birth Weights after Maternal Intrauterine Undernutrition: A Comparison within Sibships

Lumey

Stein

1997

American Journal of Epidemiology

187

100

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Section: Discussionmentioning

confidence: 99%

Offspring Birth Weights after Maternal Intrauterine Undernutrition: A Comparison within Sibships

Lumey

Stein

1997

American Journal of Epidemiology

187

100

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“…Prenatal malnutrition has been shown to be a risk factor for schizophrenia [146][147][148] . Maternal malnutrition in rats was followed by attention and gating deficits on the behavioural level but only in female offspring 149 .…”

Section: Maternal Protein Malnutritionmentioning

confidence: 99%

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Gottschalk

Sarnyai

Guest

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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Psychiatric symptoms are subjective by nature and tend to overlap between different disorders. The modelling of a neuropsychiatric disorder therefore faces challenges because of missing knowledge of the fundamental pathophysiology and a lack of accurate diagnostics. Animal models are used to test hypotheses of aetiology and to represent the human condition as close as possible to increase our understanding of the disease and to evaluate new targets for drug discovery. In this review, genetic and neurodevelopmental animal models of schizophrenia are discussed with respect to behavioural and neurophysiological findings and their association with the clinical condition. Only specific animal models of schizophrenia may ultimately lead to novel diagnostic approaches and drug discovery. We argue that molecular biomarkers are important to improve animal to human translation since behavioural readouts lack the necessary specificity and reliability to assess human psychiatric symptoms.Gottschalk MG, et al. / Rev Psiq Clín. 2013;40(1):41-50 Keywords: Translational research, neuropsychiatry, genetic, neurodevelopment, animal model, schizophrenia. ResumoSintomas psiquiátricos são subjetivos por natureza e tendem a se sobrepor entre diferentes desordens. Sendo assim, a criação de modelos de uma desordem neuropsiquiátrica encontra desafios pela falta de conhecimento dos fundamentos da fisiopatologia e diagnósticos precisos. Modelos animais são usados para testar hipóteses de etiologia e para representar a condição humana tão próximo quanto possível para aumentar nosso entendimento da doença e avaliar novos alvos para a descoberta de drogas. Nesta revisão, modelos animais genéticos e de neurodesenvolvimento de esquizofrenia são discutidos com respeito a achados comportamentais e neurofisiológicos e sua associação com a condição clínica. Somente modelos animais específicos de esquizofrenia podem, em último caso, levar a novas abordagens diagnósticas e descoberta de drogas. Argumentamos que biomarcadores moleculares são importantes para aumentar a tradução de animais a humanos, já que faltam a especificidade e a fidelidade necessárias às leituras comportamentais para avaliar sintomas psiquiátricos humanos.Gottschalk MG, et al. / Rev Psiq Clín. 2013;40(1):41-50

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“…Correspondence: H Nawa, Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan Received 31 August 1999; revised 22 September 1999 and 10 January 2000; accepted 10 January 2000 deficiency, 6 and season of birth. 7 Moreover, some neuropathological findings have suggested that this disease arises from defective embryological development in selective brain areas.…”

Section: Nutritionalmentioning

confidence: 99%

Cytokine and growth factor involvement in schizophrenia—support for the developmental model

2000

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Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. The cellular targets of the relevant factors and the nature of their actions remain to be explored in mental illness, however. Recent physiological studies demonstrate that cytokines and neurotrophic factors can markedly influence synaptic transmission and plasticity upon acute or chronic application. Moreover, many of the molecular alterations observed in the schizophrenic brain are consistent with abnormalities in cytokine and neurotrophic factor regulation of these molecules. In this review, we summarize these molecular pathology findings for schizophrenia and highlight the neurodevelopmental activities of cytokines and neurotrophic factors that may contribute to the etiology or pathology of this illness. Molecular Psychiatry (2000) 5, 594-603.

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Schizophrenia After Prenatal Famine

Abstract: Prenatal nutritional deficiency may play a role in the origin of some cases of schizophrenia.

Cited by 671 publications

References 32 publications

Offspring Birth Weights after Maternal Intrauterine Undernutrition: A Comparison within Sibships

Offspring Birth Weights after Maternal Intrauterine Undernutrition: A Comparison within Sibships

Estudos traducionais de neuropsiquiatria e esquizofrenia: modelos animais genéticos e de neurodesenvolvimento

Cytokine and growth factor involvement in schizophrenia—support for the developmental model

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