Schizophrenia—A Follow-up Study of Results of Treatment

Prospective Study of Psychobiology in First-episode Schizophrenia at Hillside Hospital

“…Duration of psychotic symptoms was the only variable significantly associated with time to remission after the variance accounted for by the other variables was removed ( χ 2 = 4.4; df = 1; p < 0.04) with longer pretreatment duration being associated with longer time to remission. These results are consistent with previous reports that found duration of illness before treatment to be correlated with poor outcome (May and Tuma 1965; May et al 1976, 1981; Huber et al 1980; Crow et al 1986). They suggest that there is an active morbid process occurring during periods of acute symptoms that, if not counteracted, produces some lasting effect that may impair patients’ subsequent response to treatment.…”

Early intervention with second‐generation antipsychotics in first‐episode psychosis: results of an 8‐week naturalistic study

“…The pharmacological treatment of first-episode psychosis presents an enormous opportunity and chal-lenge. As initially reported by May and colleagues 1 and replicated in several subsequent studies, most patients in their first episode of psychosis usually show rapid symptom improvement with antipsychotic treatment. [2][3][4][5][6][7][8][9] Compared to those with chronic illness, individuals in the initial stage of psychosis tend to be more responsive to treatment in terms of overall response rates and magnitude of symptom reduction.…”

Psychosocial interventions for people with schizophrenia or psychosis on minimal or no antipsychotic medication: A systematic review

“…For milieu therapy (May et al, 1981(May et al, , 1976, aside from longer hospital stays there were no other differences between this treatment and the antipsychotic only group. In Major Role Therapy those taking placebo experienced a higher rate of relapse (Hogarty et al, 1974b(Hogarty et al, , 1974aHogarty and Goldberg, 1973).…”