Schizencephaly in children: A single medical center retrospective study

Hung, Po-Cheng; Wang, Huei-Shyong; Chou, Ming-Liang; Lin, Kuang-Lin; Hsieh, Meng‐Ying; Chou, I-Jun; Wong, Alex Mun-Ching

doi:10.1016/j.pedneo.2018.01.009

Cited by 18 publications

(21 citation statements)

References 18 publications

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“…31 Our patient presented with giant bilateral open-lip schizencephaly with no seizures or other major symptoms, in contrast with a similar case report of giant bilateral schizencephaly in a 15 day old female, who had poor breastfeeding since birth, spasticity, seizures, and use of antiepileptic drugs. 32 Although the onset of seizures occurs mainly in childhood for patients with bilateral schizencephaly, 33 our patient is seizure-free (but there is the possibility he develops seizures later in life). Some reports state that schizencephaly is due to a functional brain reorganization in these patients; thus, the hemispherectomy used for intractable epilepsy in patients with cortical development malformations has good results, with minimal secondary effects.…”

Section: Discussionmentioning

confidence: 73%

Esquizencefalia bilateral gigante de labio abierto

Sarango-Amay¹,

Muñoz-Gualan²

2022

revecuatneurol

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Schizencephaly is a rare congenital brain malformation characterized by clefts in the cerebral cortex, it is classified in Type I (open lip) and Type II (close-lip). Patients with schizencephaly present seizures, hydrocephalus, motor and mental deficits. Ultrasound is used for in-utero and newborns patients’ diagnosis, and MRI or CT for already born patients. The management of schizencephaly is conservative, with rehabilitation in motor or mental deficits, medication or surgery for seizures and shunt in hydrocephalus with increased intracranial pressure. In the literature, only few giant bilateral cases have been reported. We report a case of giant bilateral open lip schizencephaly, in a 10-day old male patient, presenting with mild hypotonia and no seizures. This case is rare because the relatively benign features compared to other reported cases.

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Section: Discussionmentioning

confidence: 73%

Esquizencefalia bilateral gigante de labio abierto

Sarango-Amay¹,

Muñoz-Gualan²

2022

revecuatneurol

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“…Schizencephaly has rarely been associated with hypoplastic oculomotor nerve and its palsy and strabismus. [ 16 17 ] Though we cannot completely rule out the fact that this can be an incidental finding too. The vision was most severely affected in the third nerve palsy group and it was most likely due to the combination of strabismus, ptosis, and anisocoria.…”

Section: Discussionmentioning

confidence: 97%

Pediatric ocular motor cranial nerve palsy: Demographics and etiological profile

Priya

Guha

Mittal

et al. 2021

Indian J Ophthalmol

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Purpose: The aim of this study was to describe epidemiological and clinical characteristics of pediatric ocular motor cranial nerve palsy. Methods: This was a retrospective record-based study, carried out at a tertiary eye care hospital in India, between January 2011 and January 2015 and included patients up to 16 years of age at the time of presentation, diagnosed with third, fourth, sixth nerve palsy or a combination of these with other cranial nerve palsy. Data analyzed included demographic details, etiologies, presence or absence of amblyopia, relevant investigations, and management. Results: A total of 90 cases were included in the study. Eighty patients (88.88%) presented with isolated nerve palsy. Forty-three patients (47.77%) had congenital nerve palsy. The most common nerve involved was third ( n = 35, 38.88%) followed by sixth ( n = 23, 25.55%) and fourth nerve ( n = 22, 24.44%). Most common cause of third and fourth cranial nerve palsy was congenital ( n = 18, 51.42% and n = 17, 77.30%, respectively), while it was trauma for the sixth nerve ( n = 7, 30.40%). Amblyopia was most frequently associated with third cranial nerve palsy ( n = 27, 77.14%). The radio-imaging yield was maximum ( n = 7, 70%) for combined cranial nerve palsy. Overall 44 (48.88%) patients were managed conservatively, while 46 (51.11%) patients needed squint with or without ptosis surgery. Conclusion: The most common ocular motor cranial nerve involved in the pediatric population was the third cranial nerve, and it was found to be the most amblyogenic in this age group. The neuroimaging yield was maximum for combined cranial nerve palsy. The most common conservatively managed nerve palsy in this study group was the fourth nerve palsy.

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“…Vienos iš studijų rezultatai parodė net 81 proc. epilepsijos atvejų pacientams, kuriems MRT pagalba buvo nustatyta šizencefalija [17]. Melburno ligoninės pediatrijos skyriuje atliktas tyrimas parodė 75 proc.…”

Section: Diskusijaunclassified

Smegenų Žievės Struktūros Pakitimų Įtaka Psichikos Sveikatai

Jaras¹

2021

Health Sciences

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Straipsnyje aprašomas 23 metų pacientės klinikinis atvejis, prasidėjęs bloga nuotaika, nerimo simptomatika, padidėjusiu jautrumu, verksmingumu, sutrikusiu nakties miegu ir po subjektyviai reikšmingos stresogeninės situacijos pasireiškęs staigia psichozine simptomatika. Pacientė jauno amžiaus ir staiga sutrikusi psichikos sveikata buvo indikacija ieškoti galimos organinės patologijos. Gydymo eigoje atlikus detalų ištyrimą ir įvertinus galvos smegenų MRT vaizdus, nustatytas įgimtas galvos smegenų Silvijaus vagos išplitimas, galvos smegenų mikrogirija ir pachigirija. Tyrimo tikslas – pristatyti galimus psichikos būklės pasikeitimus ir simptomus, esant įgimtiems galvos smegenų struktūros pakitimams.

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Schizencephaly in children: A single medical center retrospective study

Abstract: This study demonstrates that the clinical features of schizencephaly vary widely, with their severity closely related to the cleft. Determining the type, size, and extent of schizencephaly is useful to plan management and predict the prognosis.

Cited by 18 publications

References 18 publications

Esquizencefalia bilateral gigante de labio abierto

Esquizencefalia bilateral gigante de labio abierto

Pediatric ocular motor cranial nerve palsy: Demographics and etiological profile

Smegenų Žievės Struktūros Pakitimų Įtaka Psichikos Sveikatai

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