Schistosomiasis mansoni in Bananal (State of São Paulo, Brazil): I. Efficiency of diagnostic and treatment procedures

Teles, Horacio Manuel Santana; Carvalho, Maria Esther de; Ferreira, Cláudio Santos; Zacharias, Fabiana; Lima, Valquíria R. de; Fadel, M.

doi:10.1590/s0074-02762002000900035

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…The stream runs for a length of 42 m, with an average width of 1.5 m and a depth of up to 1.5 m, before debouching into another stream with a larger volume. Previous studies indicated that B. tenagophila is the only Biomphalaria species present in this stream and in all water samples collected in the municipality of Bananal [28], [29].…”

Section: Methodsmentioning

confidence: 66%

“…This municipality was chosen because the area had been studied previously and because well-documented data regarding schistosomiasis transmission in this area were available. These data clearly indicated that B. tenagophila is the only species of mollusk responsible for the transmission of the disease in this area [28], [29]. Adopted control measures, such as the treatment of people infected with S. mansoni, the use of molluscicides and the performance of basic sanitation services by technicians at residences in the urban area of the municipality, have reduced the schistosomiasis prevalence to below 1%.…”

Section: Discussionmentioning

confidence: 85%

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Reduced Susceptibility of a Biomphalaria tenagophila Population to Schistosoma mansoni after Introducing the Resistant Taim/RS Strain of B. tenagophila into Herivelton Martins Stream

Marques

Rosa

Maciel³

et al. 2014

PLoS ONE

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Studies performed in the last 30 years demonstrated that a strain of B. tenagophila from the Taim Biological Reserve is completely resistant to Schistosoma mansoni infection. This resistance to parasite infection is a dominant characteristic during crossbreeding with susceptible B. tenagophila strains. These experiments also identified a 350 bp molecular marker that is exclusive to the Taim strain and does not occur in other geographic strains of this snail species. The Taim strain (Taim/RS) of Biomphalaria tenagophila was bred on a large scale, physically marked and introduced into a stream in which previous malacological analyses had revealed the presence of only parasite-susceptible B. tenagophila. Samples of offspring captured 4, 11 and 14 months after the introduction of the Taim strain were examined, and the susceptibility of the snails to S. mansoni infection dropped from 38.6–26.5% to 2.1% during the 14 months after the introduction of the Taim snail strain. A significant correlation was also observed between the absence of infection and the identification of the Taim molecular marker. These results demonstrate that the genetic marker from the Taim strain was successfully introduced into the wild snail population. In addition, a significant relationship exists between the marker and resistance to infection.

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Section: Methodsmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 85%

Reduced Susceptibility of a Biomphalaria tenagophila Population to Schistosoma mansoni after Introducing the Resistant Taim/RS Strain of B. tenagophila into Herivelton Martins Stream

Marques

Rosa

Maciel³

et al. 2014

PLoS ONE

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“…4,13 In Brazil, several techniques have been tested in LEAs, such as São Paulo. 12,15,36,37 In Barra Mansa, as a result of implementation of a special program for controlling schistosomiasis (Programa Especial de Controle da Esquistossomose) in 1976, schistosomiasis prevalence was around 1%. 20 The aim of this study was to compare and evaluate the accuracy of the COPT, IFA-IgM, and parasitological diagnostic techniques in the identification of S. mansoni infections, by means of epidemiological inquiry of randomized fecal and serum samples from individuals living in areas peripheral to Barra Mansa, Rio de Janeiro.…”

Section: Discussionmentioning

confidence: 99%

“…11 Also of concern is continued transmission by asymptomatic carriers who transmit the parasite in areas without adequate basic sanitation. 12 Thus, LEAs require close surveillance to prevent increased endemicity. 4 Within this context, immunodiagnostic techniques have been introduced into the schistosomiasis control programs of some countries, such as Venezuela 13 and China.…”

Section: Introductionmentioning

confidence: 99%

Detection of Schistosoma mansoni Antibodies in a Low-Endemicity Area Using Indirect Immunofluorescence and Circumoval Precipitin Test

Espírito-Santo

Pintó

Gargioni

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Parasitological diagnostic methods for schistosomiasis lack sensitivity, especially in regions of low endemicity. The objective of this study was to determine the prevalence of Schistosoma mansoni infections by antibody detection using the indirect immunofluorescence assay (IFA-IgM) and circumoval precipitin test (COPT). Serum samples of 572 individuals were randomly selected. The IFA-IgM and COPT were used to detect anti-S. mansoni antibodies. Of the patients studied, 15.9% (N = 91) were IFA-IgM positive and 5.1% (N = 29) had COPT reactions (P 0.001 by McNemar's test). Immunodiagnostic techniques showed higher infection prevalence than had been previously estimated. This study suggests that combined use of these diagnostic tools could be useful for the diagnosis of schistosomiasis in epidemiological studies in areas of low endemicity.

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“…This is particularly true in children, who may experience delayed growth and develop anemia and chronic malnutrition [ 2 ]. Moreover, asymptomatic carriers can potentially transmit schistosomiasis in areas that lack adequate sanitation [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Accuracy of Different Techniques for the Laboratory Diagnosis of Schistosomiasis Mansoni in Areas of Low Endemicity in Barra Mansa City, Rio de Janeiro State, Brazil

Espírito-Santo

Alvarado-Mora

Pintó

et al. 2015

BioMed Research International

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Schistosomiasis constitutes a major public health problem, with an estimated 200 million people infected worldwide. Many areas of Brazil show low endemicity of schistosomiasis, and the current standard parasitological techniques are not sufficiently sensitive to detect the low-level helminth infections common in areas of low endemicity (ALEs). This study compared the Kato-Katz (KK); Hoffman, Pons, and Janer (HH); enzyme-linked immunosorbent assay- (ELISA-) IgG and ELISA-IgM; indirect immunofluorescence technique (IFT-IgM); and qPCR techniques for schistosomiasis detection in serum and fecal samples, using the circumoval precipitin test (COPT) as reference. An epidemiological survey was conducted in a randomized sample of residents from five neighborhoods of Barra Mansa, RJ, with 610 fecal and 612 serum samples. ELISA-IgM (21.4%) showed the highest positivity and HH and KK techniques were the least sensitive (0.8%). All techniques except qPCR-serum showed high accuracy (82–95.5%), differed significantly from COPT in positivity (P < 0.05), and showed poor agreement with COPT. Medium agreement was seen with ELISA-IgG (Kappa = 0.377) and IFA (Kappa = 0.347). Parasitological techniques showed much lower positivity rates than those by other techniques. We suggest the possibility of using a combination of laboratory tools for the diagnosis of schistosomiasis in ALEs.

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Schistosomiasis mansoni in Bananal (State of São Paulo, Brazil): I. Efficiency of diagnostic and treatment procedures

Abstract: Bananal is an important focus of

Cited by 7 publications

References 15 publications

Reduced Susceptibility of a Biomphalaria tenagophila Population to Schistosoma mansoni after Introducing the Resistant Taim/RS Strain of B. tenagophila into Herivelton Martins Stream

Reduced Susceptibility of a Biomphalaria tenagophila Population to Schistosoma mansoni after Introducing the Resistant Taim/RS Strain of B. tenagophila into Herivelton Martins Stream

Detection of Schistosoma mansoni Antibodies in a Low-Endemicity Area Using Indirect Immunofluorescence and Circumoval Precipitin Test

Comparative Study of the Accuracy of Different Techniques for the Laboratory Diagnosis of Schistosomiasis Mansoni in Areas of Low Endemicity in Barra Mansa City, Rio de Janeiro State, Brazil

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