Schistosomiasis Japonica in American Military Personnel: Clinical Studies of 600 Cases during the First Year after Infection 1,2

Most, Harry; Kane, Charles A.; Lavietes, Paul H.; Schroeder, Edmund F.; Behm, Alton; Blum, Léon; Katzin, B.; Hayman, J. M.

doi:10.4269/ajtmh.1950.s1-30.239

Cited by 43 publications

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“…In 1950, a study reported a prevalence of cerebral schistosomiasis of 2% among the American soldiers ( n = 600) who were infected with S. japonicum from 1944 to 1945 in Leyte [38], supporting the estimate that cerebral involvement in schistosomiasis occurs in 2% to 5% of infected individuals [39]. The high prevalences of schistosomiasis and neuroschistosomiasis, coupled with a report suggesting that T. saginata infections are more common than T. solium infections in humans in the Philippines [16, 21], have contributed to the underappreciation of T. solium as a potential cause of neurological complications in the study area.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Cysticercosis in Children and Young Adults Living in a Helminth Endemic Community in Leyte, the Philippines

Acosta

Hou

et al. 2010

Journal of Tropical Medicine

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Cysticercosis is a significant public health problem in countries where pigs are raised for consumption and remains an important cause of neurological disease worldwide. The Philippines is considered an endemic area for cysticercosis because cases in both humans and pigs have been reported; however, epidemiologic information stays limited. We conducted a pilot survey of the seroprevalence of human cysticercosis in a village in Leyte, the Philippines, by measuring antibody specific for Taenia solium cyst-fluid antigen. There were 497 subjects aged 7–30 years in our study and most subjects were infected with one or more helminths. The overall cysticercosis seroprevalence in this population was 24.6% (95% CI: 20.82% ~ 28.58%) with no significant difference based on age, sex, or other helminth coinfection status. Although the sample may not be representative of the whole community, the findings suggest that cysticercosis is a significant, but underrecognized public health concern in the Philippines.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Cysticercosis in Children and Young Adults Living in a Helminth Endemic Community in Leyte, the Philippines

Acosta

Hou

et al. 2010

Journal of Tropical Medicine

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“…Cardiac injuries such as myocarditis, pericarditis or asymptomatic myocardial ischaemia have also been described during AS [29,44,45]. As was the case for neurological complications, the first description of cardiac complications was made during the Leyte campaign [46]. An analysis of 315 electrocardiograms revealed various repolarization abnormalities: anomalies of T‐waves (99%) or ST segments (52%).…”

Section: Life‐threatening Complicationsmentioning

confidence: 99%

Acute schistosomiasis, a diagnostic and therapeutic challenge

Jauréguiberry

Paris

Caumes

2010

Clinical Microbiology and Infection

114

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In non-endemic countries, acute (invasive) schistosomiasis (AS) is typically seen in non-immune travellers, whereas chronic schistosomiasis is more frequently diagnosed in immigrants. Travellers with AS initially present with non-specific signs such as fever, cough, headache, and urticaria. Life-threatening cardiac and neurological complications may occur. The positive diagnosis of AS relies on seroconversion, which appears together with hypereosinophilia approximately 3 weeks after the onset of symptoms. When prescribed during AS, praziquantel usually does not prevent the chronic phase of the disease and is associated with exacerbation of signs and symptoms in approximately 50% of cases. According to the published literature, corticosteroids may be recommended alone or in association with praziquantel. When associated with corticosteroids, pharmacokinetic interactions may impair the efficacy of praziquantel. We suggest that corticosteroids should be restricted to use in patients with systemic complications of AS, whereas praziquantel should be initiated only when ova are detected in either stools or urine, depending on the culprit species.

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“…In severely affected areas, a notable proportion of the surviving population had dwarfism (up to 5%) and a smaller proportion would be expected to have epilepsy-both consequences of S. japonicum infection (33,127). Wasting, weakness, and ascites were much more frequent manifestations and incapacitated a large proportion of the rural population before they succumbed to premature deaths in their third or fourth decades.…”

Section: Historical Importance Of the Diseasementioning

confidence: 99%

Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century

et al. 2001

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Schistosomiasis japonica is a serious communicable disease and a major disease risk for more than 30 million people living in the tropical and subtropical zones of China. Infection remains a major public health concern despite 45 years of intensive control efforts. It is estimated that 865,000 people and 100,250 bovines are today infected in the provinces where the disease is endemic, and its transmission continues. Unlike the other schistosome species known to infect humans, the oriental schistosome, Schistosoma japonicum, is a true zoonotic organism, with a range of mammalian reservoirs, making control efforts extremely difficult. Clinical features of schistosomiasis range from fever, headache, and lethargy to severe fibro-obstructive pathology leading to portal hypertension, ascites, and hepatosplenomegaly, which can cause premature death. Infected children are stunted and have cognitive defects impairing memory and learning ability. Current control programs are heavily based on community chemotherapy with a single dose of the drug praziquantel, but vaccines (for use in bovines and humans) in combination with other control strategies are needed to make elimination of the disease possible. In this article, we provide an overview of the biology, epidemiology, clinical features, and prospects for control of oriental schistosomiasis in the People's Republic of China

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Schistosomiasis Japonica in American Military Personnel: Clinical Studies of 600 Cases during the First Year after Infection 1,2

Cited by 43 publications

References 0 publications

Seroprevalence of Cysticercosis in Children and Young Adults Living in a Helminth Endemic Community in Leyte, the Philippines

Seroprevalence of Cysticercosis in Children and Young Adults Living in a Helminth Endemic Community in Leyte, the Philippines

Acute schistosomiasis, a diagnostic and therapeutic challenge

Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century

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