Schistosomiasis in Malaysia: A review

Chuah, Candy; Gobert, Geoffrey N.; Latif, Baha; Heo, Chong Chin; Leow, Chiuan Yee

doi:10.1016/j.actatropica.2018.11.012

Cited by 38 publications

(32 citation statements)

References 56 publications

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“…Essentially, the disease is grouped into two: urogenital schistosomiasis and intestinal schistosomiasis based on the organs affected ( Njunda et al., 2017 ). Basically, six major species infect man— Schistosoma haematobium (etiological agent of urogenital schistosomiasis) , S. intercalatum, S. mekongi , S. japonicum, S. mansoni and S. guineensis (etiological agents of intestinal schistosomiasis)— however, S. haematobium , S. japonicum and S. mansoni are most pathogenic ( Steinmann et al., 2006 ; Chuah et al., 2019 ). Not less than 240 million people are affected by schistosomiasis globally and about 200,000 deaths recorded yearly ( Thétiot-Laurent et al., 2013 ; Hotez et al., 2014 ; WHO, 2019b ).…”

Section: Introductionmentioning

confidence: 99%

Malaria coinfection with Neglected Tropical Diseases (NTDs) in children at Internally Displaced Persons (IDP) camp in Benin City, Nigeria

Edosomwan

Evbuomwan

Agbalalah

et al. 2020

Heliyon

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Malaria and Neglected Tropical Diseases (NTDs) are highly endemic in poorer countries of the world. The research investigated the prevalence of parasitic infections among children in Internally Displaced Persons (IDP) camp in Benin City. Faecal, urine and blood specimen were collected from 184 children (100 males and 84 females) aged 6–15. Blood samples were prepared using thick film method and analyzed microscopically. Direct smear technique was employed for faecal sample and sedimentation method to concentrate ova from the urine sample. Ten species of parasites were identified in this study. The predominant species were Plasmodium falciparum (67.93%), Entamoeba histolytica (67.93%) and Giardia duodenalis (59.78%). Plasmodium falciparum and E. histolytica were most prevalent in both sexes, with P. falciparum infecting 68% males and 67.86% females while E. histolytica infected 66% males and 70.24% females ( P = 0.24). Mixed infections with blood and intestinal parasites were recorded in 41.18% in age group 5–10 and 47.90% in age group 11–15 ( P < 0.5). Also, mixed infections with blood and intestinal parasites were detected in 45% males and 50% females ( P = 0.51). Urinary schistosomiasis was recorded in 28.80% of the participants. Parasitic infections especially P. falciparum malaria and amoebiasis were predominant among the children. Therefore, our findings call for specific intervention programmes to reduce parasite intensity and morbidity in the children. Environmental and personal hygiene should be implemented in order to curb parasitosis in the study area.

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Section: Introductionmentioning

confidence: 99%

Malaria coinfection with Neglected Tropical Diseases (NTDs) in children at Internally Displaced Persons (IDP) camp in Benin City, Nigeria

Edosomwan

Evbuomwan

Agbalalah

et al. 2020

Heliyon

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“…Schistosomiasis (also known as Bilharziasis) is a parasitic infection caused by several species of blood-flukes of the genus Schistosoma and it is one of the most prevalent zoonotic diseases, affecting over 258 million individuals in 54 countries (McManus et al 2018 ; Chuah et al 2019 ; Salari et al 2020 ). Trematode parasites S. mansoni (mainly distributed in Africa, South America, Caribbean, and the Middle East), S. haematobium (Africa and the Middle East), and S. japonicum (China and Southeast Asia) are the main species that cause this human disease (Meningher et al 2020 ).…”

Section: Mirnas: Fine Modulators Of Parasitic Infectionsmentioning

confidence: 99%

Human microRNAs in host–parasite interaction: a review

et al. 2020

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MicroRNAs (miRNAs) are a group of small noncoding RNA molecules with significant capacity to regulate the gene expression at the post-transcriptional level in a sequence-specific manner either through translation repression or mRNA degradation triggering a fine-tuning biological impact. They have been implicated in several processes, including cell growth and development, signal transduction, cell proliferation and differentiation, metabolism, apoptosis, inflammation, and immune response modulation. However, over the last few years, extensive studies have shown the relevance of miRNAs in human pathophysiology. Common human parasitic diseases, such as Malaria, Leishmaniasis, Amoebiasis, Chagas disease, Schistosomiasis, Toxoplasmosis, Cryptosporidiosis, Clonorchiasis, and Echinococcosis are the leading cause of death worldwide. Thus, identifying and characterizing parasite-specific miRNAs and their host targets, as well as host-related miRNAs, are important for a deeper understanding of the pathophysiology of parasite-specific diseases at the molecular level. In this review, we have demonstrated the impact of human microRNAs during host−parasite interaction as well as their potential to be used for diagnosis and prognosis purposes.

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“…Schistosomiasis affects more than 250 million people worldwide, and some estimates indicate that the disease can cause more than 11 700 deaths per year . Current control strategies for schistosomiasis mainly rely on chemotherapy but there are concerns about resistance to the primary drug, praziquantel .…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity, antibody responses and vaccine efficacy of recombinant annexin B30 against Schistosoma mansoni

Leow

Willis

Chuah

et al. 2020

Parasite Immunology

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Aims Schistosomes infect approximately 250 million people worldwide. To date, there is no effective vaccine available for the prevention of schistosome infection in endemic regions. There remains a need to develop means to confer long‐term protection of individuals against reinfection. In this study, an annexin, namely annexin B30, which is highly expressed in the tegument of Schistosoma mansoni was selected to evaluate its immunogenicity and protective efficacy in a mouse model. Methods and results Bioinformatics analysis showed that there were three potential linear B‐cell epitopes and four conformational B‐cell epitopes predicted from annexin B30, respectively. Full‐length annexin B30 was cloned and expressed in Escherichia coli BL21(DE3). In the presence of adjuvants, the soluble recombinant protein was evaluated for its protective efficacy in two independent vaccine trials. Immunization of CBA mice with recombinant annexin B30 formulated either in alum only or alum/CpG induced a mixed Th1/Th2 cytokine profile but no significant protection against schistosome infection was detected. Conclusion Recombinant annexin B30 did not confer significant protection against the parasite. The molecule may not be suitable for vaccine development. However, it could be an ideal biomarker recommended for immunodiagnostics development.

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Schistosomiasis in Malaysia: A review

Cited by 38 publications

References 56 publications

Malaria coinfection with Neglected Tropical Diseases (NTDs) in children at Internally Displaced Persons (IDP) camp in Benin City, Nigeria

Malaria coinfection with Neglected Tropical Diseases (NTDs) in children at Internally Displaced Persons (IDP) camp in Benin City, Nigeria

Human microRNAs in host–parasite interaction: a review

Immunogenicity, antibody responses and vaccine efficacy of recombinant annexin B30 against Schistosoma mansoni

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