Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium–S. mansoni foci of Niger

Garba, Amadou; Barkiré, Nouhou; Djibo, Ali; Lamine, Mariama S.; Sofo, Boubacar; Gouvras, Anouk N.; Bosqué-Oliva, Elisa; Webster, Joanne P.; Stothard, J. Russell; Utzinger, Jürg; Fenwick, Alan

doi:10.1016/j.actatropica.2010.03.005

Cited by 105 publications

(102 citation statements)

References 28 publications

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“…With regards to gender, the present study found a signifi cant difference in the prevalence of schistosomiasis between male and female participants. These are consistent with many other reports worldwide (Garba et al, 2010;Ahmed et al, 2012). Males usually have higher prevalence rates of schistosomiasis than females and this was attributed to religious and cultural reasons or to water contact behavior (El-Khoby et al, 2000;Haidar, 2001;Matthys et al, 2007;Deribe et al, 2011).…”

Section: Discussionsupporting

confidence: 81%

Some epidemiological and serological studies on schistosomiasis in Najran area, Saudi Arabia

Elshahawy¹,

Mohamed

Adail

2016

Helminthologia

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SummarySchistosomiasis is a major cause of morbidity and mortality and has been estimated to infect over 200 million people. Diagnosis of schistosomiasis by detection of specifi c antibodies is likely to be more sensitive than the traditional method of diagnosis by detection of eggs in stool or urine. Therefore the present study was the fi rst attempt to highlight the seroepidemiology of schistosomiasis among the general population of Najran City, southern of Saudi Arabia, as well as to achieve the performance of the diagnostic tests used. A total of 180 participants attending King Khaled hospital in Najran Province, Saudi Arabia, over a one year period, from September 2013 to September 2014 were screened for the presence of Schistosoma antibody in their blood serum using an indirect hemagglutination assay (IHA). Specifi c immunoglobulin (Ig) G antibody was evaluated using an enzyme-linked immunosorbent assay (ELISA). Out of the 180 samples of sera tested using IHA, 32 (20 %) were found to be positive with a titer ranging from 1:160 to 1:1280, while 42(23.2 %) revealed Schistosoma IgG. A positive relationship was found between the seroprevalence of schistosomiasis and age of tested participants, especially in the age group of 20-40 years old. Additionally, prevalence of infection was more in males (36 %) than females (7.5 %), and showed statistical significance (P < 0.001). Similarly, there was signifi cant association between the presence of Schistosoma antibodies and the nationality of residence, and education of participants (P < 0.05). The current investigation reveals an alarmingly high prevalence of schistosomiasis among participants in Najran, southern region of Saudi Arabia and this supports an urgent need to re-evaluate the current control measures and implement an integrated, targeted and effective schistosomiasis control measures.

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Section: Discussionsupporting

confidence: 81%

Some epidemiological and serological studies on schistosomiasis in Najran area, Saudi Arabia

Elshahawy¹,

Mohamed

Adail

2016

Helminthologia

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“…These children, who are infected by the parasite, are a source of continuous reinfestation for the community and are therefore those who are likely to benefit the most from the program. 18,20,21 It is difficult to determine the extent to which the treatment is effective in controlling the disease, and what the impact of the currently ongoing health education campaigns and construction of latrines program really is. It is therefore necessary to continue running health and hygiene programs for the village inhabitants because the role of sanitation and hygiene is crucial to interrupt Schistosoma life cycle.…”

Section: Discussionmentioning

confidence: 99%

Schistosomiasis Sustained Control Program in Ethnic Groups Around Ninefescha (Eastern Senegal)

N’Diaye¹,

Dioukhane²,

Ndao³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…14 With more sensitive testing, there is greater evidence that Schistosoma infection begins in very early childhood. [15][16][17] While children under 5 years are not yet included in WHO preventive chemotherapy protocols, 18 anti-schistosomal treatment with praziquantel for preschool children could be easily synergized with the ongoing STH early childhood strategies for the prevention of anemia. 18 The aim of this study was to use more in-depth laboratory testing to identify the most likely mechanisms for anemia among children in a resource-limited area endemic for multiple chronic parasitic infections, with the goal of informing local and regional choices for management of early childhood anemias.…”

Section: Introductionmentioning

confidence: 99%

Anemia Among Children Exposed to Polyparasitism in Coastal Kenya

Cojulun

Bustinduy

Sutherland

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Anemia represents a substantial problem for children living in areas with limited resources and significant parasite burden. We performed a cross-sectional study of 254 Kenyan preschool-and early school-age children in a setting endemic for multiple chronic parasitic infections to explore mechanisms of their anemia. Complete venous blood cell counts revealed a high prevalence of local childhood anemia (79%). Evaluating the potential links between low hemoglobin and socioeconomic factors, nutritional status, hemoglobinopathy, and/or parasite infection, we identified age < 9 years (odds ratio [OR]: 12.0, 95% confidence interval [CI]: 4.4, 33) and the presence of asymptomatic malaria infection (OR: 6.8, 95% CI: 2.1, 22) as the strongest independent correlates of having anemia. A total of 130/155 (84%) of anemic children with iron studies had evidence of iron-deficiency anemia (IDA), 16% had non-IDA; 50/52 of additionally tested anemic children met soluble transferrin-receptor (sTfR) criteria for combined anemia of inflammation (AI) with IDA. Children in the youngest age group had the greatest odds of iron deficiency (OR: 10.0, 95% CI: 3.9, 26). Although older children aged 9-11 years had less anemia, they had more detectable malaria, Schistosoma infection, hookworm, and proportionately more non-IDA. Anemia in this setting appears multifactorial such that chronic inflammation and iron deficiency need to be addressed together as part of integrated management of childhood anemia.

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Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium–S. mansoni foci of Niger

Cited by 105 publications

References 28 publications

Some epidemiological and serological studies on schistosomiasis in Najran area, Saudi Arabia

Some epidemiological and serological studies on schistosomiasis in Najran area, Saudi Arabia

Schistosomiasis Sustained Control Program in Ethnic Groups Around Ninefescha (Eastern Senegal)

Anemia Among Children Exposed to Polyparasitism in Coastal Kenya

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