Schistosomiasis in Cattle

Bont, Jettie; Vercruysse, Jozef

doi:10.1016/s0065-308x(08)60426-1

Cited by 65 publications

(49 citation statements)

References 164 publications

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“…Embryonated eggs are either eliminated in feces or trapped in tissues developing severe intestinal and liver chronic disease. Most S. bovis infections in grazing ruminants in endemic areas occur at a subclinical level causing significant losses due to long-term effects on ruminants as well as to an increased susceptibility to other pathogens (de Bont and Vercruysse, 1998;Vercruysse and Gabriel, 2005). Natural infections elicit a concomitant immunity acting through a reduction of female fecundity observed with reductions in fecal and tissue eggs without effects in worm burden that seems produced by serum factors (Vercruysse and Gabriel, 2005).…”

Section: Introductionmentioning

confidence: 99%

The combination of the aliphatic diamine AA0029 in ADAD vaccination system with a recombinant fatty acid binding protein could be a good alternative for the animal schistosomiasis control

Vicente

López‐Abán

Rojas-Caraballo

et al. 2015

Experimental Parasitology

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Section: Introductionmentioning

confidence: 99%

The combination of the aliphatic diamine AA0029 in ADAD vaccination system with a recombinant fatty acid binding protein could be a good alternative for the animal schistosomiasis control

Vicente

López‐Abán

Rojas-Caraballo

et al. 2015

Experimental Parasitology

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“…The disease has a high socioeconomic impact causing annual losses of 1.7 to 4.5 million disability adjusted life years (DALYs) of humans living in endemic areas [5], [6], but tourists and travelers can also be affected [7]. Besides humans, animals including cattle can get infected, too, which causes economic losses [8]–[11].…”

Section: Introductionmentioning

confidence: 99%

Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects

et al. 2014

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BackgroundSchistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives. Studies on protein kinases (PKs) demonstrated their importance for diverse physiological processes in schistosomes. Among others two Abl tyrosine kinases, SmAbl1 and SmAbl2, were identified in Schistosoma mansoni and shown to be transcribed in the gonads and the gastrodermis. SmAbl1 activity was blocked by Imatinib, a known Abl-TK inhibitor used in human cancer therapy (Gleevec/Glivec). Imatinib exhibited dramatic effects on the morphology and physiology of adult schistosomes in vitro causing the death of the parasites.Methodology/Principal FindingsHere we show modeling data supporting the targeting of SmAbl1/2 by Imatinib. A biochemical assay confirmed that SmAbl2 activity is also inhibited by Imatinib. Microarray analyses and qRT-PCR experiments were done to unravel transcriptional processes influenced by Imatinib in adult schistosomes in vitro demonstrating a wide influence on worm physiology. Surface-, muscle-, gut and gonad-associated processes were affected as evidenced by the differential transcription of e.g. the gynecophoral canal protein gene GCP, paramyosin, titin, hemoglobinase, and cathepsins. Furthermore, transcript levels of VAL-7 and egg formation-associated genes such as tyrosinase 1, p14, and fs800-like were affected as well as those of signaling genes including a ribosomal protein S6 kinase and a glutamate receptor. Finally, a comparative in silico analysis of the obtained microarray data sets and previous data analyzing the effect of a TGFβR1 inhibitor on transcription provided first evidence for an association of TGFβ and Abl kinase signaling. Among others GCP and egg formation-associated genes were identified as common targets.Conclusions/SignificanceThe data affirm broad negative effects of Imatinib on worm physiology substantiating the role of PKs as interesting targets.

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“…About 530 million cattle live in endemic regions of Africa and Asia. Regional prevalence studies demonstrated infection rates between 31% and 81%, which resulted in an estimate of about 165 million infected animals [8]. In addition to cattle water buffaloes play a serious role as hosts for S. japonicum.…”

Section: Introductionmentioning

confidence: 99%

Protein Kinases as Potential Targets for Novel Anti-Schistosomal Strategies

Beckmann

Leutner²,

Gouignard³

et al. 2012

cpd

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Schistosome parasites are the causative pathogens of schistosomiasis (bilharzia), a disease of worldwide significance. In terms of patient numbers, schistosomiasis ranks second to malaria as a parasitosis affecting more than 200 million people of the tropics and subtropics. Since the 1970s Praziquantel (PZQ) is the drug of choice and nearly exclusively used for treatment. However, drug resistance is an increasing threat, particularly with respect to large-scale PZQ administration programs. Last decade´s research indicated that resistance against PZQ can be induced under laboratory conditions, and field studies provided first indications for the possibility of reduced PZQ efficacy. Furthermore, clear evidence for the molecular armamentarium of schistosomes with multidrug transporters was found, one of which was responding to PZQ challenge. Also the development of a vaccine still represents an elusive goal, although effort and time have been invested in this subject. In light of these facts it is commonly accepted that new drugs are urgently needed. Research on signal transduction processes in Schistosoma mansoni has provided an unexpected and novel perspective towards this end. Molecular, biochemical, and physiological studies elucidating principles of schistosome development have demonstrated the essential role of protein kinases (PKs). In humans, PKs are known to be involved in cancer development. Since a variety of approved anticancer drugs targeting PKs exist, first studies have been performed to investigate whether these drugs are able to also inhibit schistosome PKs. Indeed, promising results have been obtained indicating the potential of PKs as privileged targets for new concepts in fighting schistosomes.

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Schistosomiasis in Cattle

Cited by 65 publications

References 164 publications

The combination of the aliphatic diamine AA0029 in ADAD vaccination system with a recombinant fatty acid binding protein could be a good alternative for the animal schistosomiasis control

The combination of the aliphatic diamine AA0029 in ADAD vaccination system with a recombinant fatty acid binding protein could be a good alternative for the animal schistosomiasis control

Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects

Protein Kinases as Potential Targets for Novel Anti-Schistosomal Strategies

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