Schistosoma mansoni: Melatonin enhances efficacy of cercarial and soluble worm antigens in the induction of protective immunity against infection in the hamster

Soliman, Maha F. M.; Shenawy, Nahla S. El; Arabi, Shimaa E. El

doi:10.1016/j.exppara.2008.01.013

Cited by 17 publications

(20 citation statements)

References 23 publications

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“…In a model of schistosomiasis in hamsters, melatonin increases the efficacy of cercarial and soluble worm antigens in inducing protective immunity against infection, suggesting possible applications in a vaccination program [26]. Melatonin can synchronize the cycle of the malaria parasite; the rupture of infected erythrocytes coincides with the timed release of melatonin in vertebrates, which occurs between midnight and three a.m. [27].…”

Section: Discussionmentioning

confidence: 99%

Melatonin reduces the severity of experimental amoebiasis

et al. 2011

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BackgroundMelatonin has immunomodulatory effects but very little is known about its influence in protozoan infections, such as Entamoeba histolytica, which causes amoebiasis, a disease with significant morbidity and mortality. In this study, we evaluated the effects of exogenous melatonin interference in experimental amoebiasis and on interactions between human blood cells and E. histolytica trophozoites.MethodsThe effect of melatonin was investigated in models of experimental amoebiasis in hamsters and rats by evaluating the area of necrosis induced by E. histolytica. The activity of melatonin on the interactions between leukocytes and amoebae was determined by examining leukophagocytosis. For in vitro tests, polymorphonuclear and mononuclear human blood leucocytes were incubated with E. histolytica trophozoites.ResultsThe areas of amoebic necrosis were significantly reduced in animals treated with melatonin. Melatonin treatment increased leukophagocytosis but was associated with a greater number of dead amoebae.ConclusionsThese results suggest that melatonin may play a beneficial role in the control of amoebic lesions, raising the possibility that this drug may be used as an adjuvant in anti-amoebic therapy.

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Section: Discussionmentioning

confidence: 99%

Melatonin reduces the severity of experimental amoebiasis

et al. 2011

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“…To evaluate this, the administration of melatonin in combination with different immunization regimens using various Schistosoma mansoni antigens in hamsters (with schistosomiasis) was evaluated [287]. Melatonin provided excellent enhancement of vaccine action with cercarial and soluble worm antigens; this was accompanied by significant improvements in GSH levels.…”

Section: Clinical Relevance Of Melatoninmentioning

confidence: 99%

Melatonin: Buffering the Immune System

Carrillo-Vico

Lardone

Álvarez-Sánchez

et al. 2013

IJMS

552

415

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Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.

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“…The ability of adjuvants to enhance the immune responses to vaccine antigen has long been investigated and the search for adequate adjuvants is critical for improving the performance of existing vaccines, and a role of melatonin as adjuvant has been described [7-11]. Our results indicate that melatonin significantly enhanced the immune response to vaccination against the Clostridium perfringens type D , which, together with our previous studies in non-pregnant sheep, strongly suggest that melatonin enhances the immune response to vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin regulates the immune system by affecting cytokine production, enhancing the production of several T helper cytokines and modulating the IL-2/IL-2R system [4-6]. Melatonin has been shown to exert a positive effect as an adjuvant of a number of vaccines [7-11]. Platelet function is also regulated by melatonin binding to high-affinity sites [12], which results in enhanced platelet responsiveness to physiological agonist and inducing beneficial effects on platelet function and haemostasis [8].…”

Section: Introductionmentioning

confidence: 99%

Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep

et al. 2012

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BackgroundMelatonin regulates several physiological processes and its powerful action as antioxidant has been widely reported. Melatonin acts modulating the immune system, showing a protective effect on the cardiovascular system and improving vaccine administration as an adjuvant-like agent. Here, we have investigated the role of melatonin as an adjuvant of the Clostridium perfringens vaccine in prepartum sheep and whether melatonin modulates platelet physiology during peripartum.ResultsThe experiments were carried out in peripartum sheep from a farm located in an area of Mediterranean-type ecosystem. Plasma melatonin levels were determined by ELISA and sheep platelet aggregation was monitored using an aggregometer. Here we demonstrated for the first time that plasma melatonin concentration were higher in pregnant (125 pg/mL) than in non-pregnant sheep (15 pg/mL; P < 0.05). Administration of melatonin prepartum did not significantly modify platelet function but significantly improved the immune response to vaccination against C. perfringens.ConclusionAdministration of melatonin as an adjuvant provides a significant improvement in the immune response to vaccine administration prepartum against C. perfringens.

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Schistosoma mansoni: Melatonin enhances efficacy of cercarial and soluble worm antigens in the induction of protective immunity against infection in the hamster

Cited by 17 publications

References 23 publications

Melatonin reduces the severity of experimental amoebiasis

Melatonin reduces the severity of experimental amoebiasis

Melatonin: Buffering the Immune System

Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep

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