Schistosoma mansoni antigens alter activation markers and cytokine profile in lymphocytes of patients with asthma

Almeida, Tarcísio Vila Verde Santana de; Fernandes, Jamille Souza; Lopes, Diego Mota; Andrade, Lorena Santana; Oliveira, Sérgio C.; Carvalho, Edgar M.; Araújo, Maria Ilma; Cruz, Álvaro Augusto; Cardoso, Luciana Santos

doi:10.1016/j.actatropica.2016.12.002

Cited by 13 publications

(6 citation statements)

References 83 publications

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“…Collectively, the study by Cardoso et al ( 83 ) implied that Tregs might play a key role in this process of immune modulation. However, different insights were obtained with Sm29 in a human study by de Almeida et al ( 38 ), in which by employing peripheral blood mononuclear cells (PBMC) isolated from asthmatic patients, Sm29 and Sm29TSP-2 (a chimeric antigen comprised of Sm29 and SmTSP-2) were tested for their ability to modulate lymphocyte activation in response to the house dust mite allergen Der p1 . The addition of both antigens to PMBC cultures from asthmatic subjects stimulated with Der p1 showed an increased frequency of CD4 + CD25 hi T lymphocytes and a decreased frequency in the population of CD4 + CD25 low cells compared with unstimulated groups; in contrast, no significant difference was observed in the frequency of CD4 + CD25 hi T cells expressing Foxp3 in the cultures stimulated with Der p1 in the presence or absence of either antigen ( 38 ).…”

Section: Therapeutic Potential Of Live Schistosome Infection and Schimentioning

confidence: 99%

Schistosome Infection and Schistosome-Derived Products as Modulators for the Prevention and Alleviation of Immunological Disorders

McManus

Hou

et al. 2021

Front. Immunol.

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Parasitic helminths, comprising the flatworms (tapeworms and flukes) and nematodes (roundworms), have plagued humans persistently over a considerable period of time. It is now known that the degree of exposure to these and other pathogens inversely correlates with the incidence of both T helper 1 (Th1)-mediated autoimmunity and Th2-mediated allergy. Accordingly, there has been recent increased interest in utilizing active helminth worm infections and helminth-derived products for the treatment of human autoimmune and inflammatory diseases and to alleviate disease severity. Indeed, there is an accumulating list of novel helminth derived molecules, including proteins, peptides, and microRNAs, that have been shown to exhibit therapeutic potential in a variety of disease models. Here we consider the blood-dwelling schistosome flukes, which have evolved subtle immune regulatory mechanisms that promote parasite survival but at the same time minimize host tissue immunopathology. We review and discuss the recent advances in using schistosome infection and schistosome-derived products as therapeutics to treat or mitigate human immune-related disorders, including allergic asthma, arthritis, colitis, diabetes, sepsis, cystitis, and cancer.

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Section: Therapeutic Potential Of Live Schistosome Infection and Schimentioning

confidence: 99%

Schistosome Infection and Schistosome-Derived Products as Modulators for the Prevention and Alleviation of Immunological Disorders

McManus

Hou

et al. 2021

Front. Immunol.

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“…Parasitic helminths have immunosuppressive effects in the intestine and have been investigated as treatments for inflammatory disorders including IBD, multiple sclerosis, asthma and atopy . Schistosoma mansoni antigens can increase Treg frequencies and IL‐10 production from PBMCs isolated from patients with asthma . Likewise, stimulation of PBMCs with an excretory/secretory antigen from Marshallagia marshalli decreased expression of IFN‐γ and IL‐4 and increased expression of IL‐10 and TGF‐β .…”

Section: Human Studies On Probiotics Prebiotics and Helminthsmentioning

confidence: 99%

Contributions of the intestinal microbiome in lung immunity

2017

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The intestine is a critical site of immune cell development that not only controls intestinal immunity but extra-intestinal immunity as well. Recent findings have highlighted important roles for gut microbiota in shaping lung inflammation. Here, we discuss interactions between the microbiota and immune system including T cells, protective effects of microbiota on lung infections, the role of diet in shaping the composition of gut micro-biota and susceptibility to asthma, epidemiologic evidence implicating antibiotic use and microbiota in asthma and clinical trials investigating probiotics as potential treatments for atopy and asthma. The systemic effects of gut microbiota are partially attributed to their generating metabolites including short chain fatty acids, which can suppress lung inflammation through the activation of G protein-coupled receptors. Thus, studying the interactions between microbiota and immune cells can lead to the identification of therapeutic targets for chronic lower respiratory diseases.

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“…Schistosoma antigens modulate airway inflammation via IL-10 and/or CD4 + CD25 + Foxp3 + Tregs in mice 11,13 and change cytokine secretion and the activation of lymphocytes from asthmatic patients. 14 However, infectious or whole proteins may elicit side effects to patients. Therefore, seeking small molecules from helminths, such as peptides, for use as immunomodulatory drugs, can be a safe choice for preventing and treating asthma.…”

Section: Introductionmentioning

confidence: 99%

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Zhang

Zheng

et al. 2019

J Cellular Molecular Medi

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Helminths and their products can shape immune responses by modulating immune cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum. SJMHE1 can inhibit delayed‐type hypersensitivity and collagen‐induced arthritis in mice. In the present study, we evaluated this peptide's potential intervention effect and mechanism on ovalbumin‐induced asthma in mice. SJMHE1 treatment suppressed airway inflammation in allergic mice, decreased the infiltrating inflammatory cells in the lungs and bronchoalveolar lavage fluid, modulated the production of pro‐inflammatory and anti‐inflammatory cytokines in the splenocytes and lungs of allergic mice, reduced the percentage of Th2 cells and increased the proportion of Th1 and regulatory T cells (Tregs). At the same time, Foxp3 and T‐bet expression increased, and GATA3 and RORγt decreased in the lungs of allergic mice. We proved that SJMHE1 can interrupt the development of asthma by diminishing airway inflammation in mice. The down‐regulation of Th2 response and the up‐regulation of Th1 and Tregs response may contribute to the protection induced by SJMHE1 in allergic mice. SJMHE1 can serve as a novel therapy for asthma and other allergic or inflammatory diseases.

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Schistosoma mansoni antigens alter activation markers and cytokine profile in lymphocytes of patients with asthma

Cited by 13 publications

References 83 publications

Schistosome Infection and Schistosome-Derived Products as Modulators for the Prevention and Alleviation of Immunological Disorders

Schistosome Infection and Schistosome-Derived Products as Modulators for the Prevention and Alleviation of Immunological Disorders

Contributions of the intestinal microbiome in lung immunity

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

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