Schistosoma japonicum translationally controlled tumour protein, which is associated with the development of female worms, as a target for control of schistosomiasis

Zhong, Haoran; Ren, Yuqi; Qin, Fanglin; Li, Xiaochun; Hou, Ling; Gu, Shaopeng; Jin, Yamei

doi:10.1016/j.ijpara.2022.01.005

Cited by 7 publications

(16 citation statements)

References 46 publications

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“…Gene ontology functional annotations demonstrated that 34 DEPs down-regulated in MF worms at all four time points were mainly involved in actin-related cell cyclerelated functions, whereas 44 DEPs up-regulated in MF worms were involved in protein folding and hydrolysis, redox reactions, translation, and calcium ion binding (37,60,61). Schistosoma japonicum translationally controlled tumor protein (SjTCTP), which was highly expressed in MF worms at 18, 21, 23, and 25 dpi, is essential to the development of S. japonicum and recombinant SjTCTP was reported to stimulate partial protective immunity against schistosome infection in BALB/c mice (37).…”

Section: Proteomicsmentioning

confidence: 99%

“…Schistosomes are highly complex organisms, thus dynamic analysis of the developmental stages is warranted (59). Based on the life cycle of S. japonicum (mating at 15 or 16 dpi, eggshell formation at 22 dpi, and egg laying at 24 dpi) (1), the proteomic profiles of SF and MF worms at 18, 21, 23, and 25 dpi were elucidated by our group (37,45). In total, 2835 differentially expressed proteins (DEPs) were identified between SF and MF worms at different developmental stages (37).…”

Section: Proteomicsmentioning

confidence: 99%

“…In general, SF worms are about one-third of the length of MF worms, which renders detection relatively difficult ( 36 ). In S. japonicum , developed ovaries could be observed in MF worms at 18 day post infection (dpi) (2–3 days after mating) ( 37 ). From 21–25 dpi, MF worms continue to develop with proliferation of vitelline cells, while the ovaries and vitelline glands of SF worms were stunted which contains only stage I vitellocytes ( 38 ).…”

Section: Morphological Differences Between Single-sex and Bisexual Wormsmentioning

confidence: 99%

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Single-sex schistosomiasis: a mini review

Zhong

Jin

2023

Front. Immunol.

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Schistosomiasis is a neglected tropical disease caused by dioecious blood flukes of the genus Schistosoma and second to malaria as a parasitic disease with significant socio-economic impacts. Mating is essential for maturation of male and female schistosomes and for females to lay of eggs, which are responsible for the pathogenesis and propagation of the life cycle beyond the mammalian host. Single-sex schistosomes, which do not produce viable eggs without mating, have been overlooked given the symptomatic paucity of the single-sex schistosomiasis and limited diagnostic toolkit. Besides, single-sex schistosomes are less sensitive to praziquantel. Therefore, these issues should be considered to achieve the elimination of this infection disease. The aim of this review is to summarize current progress in research of single-sex schistosomes and host-parasite interactions.

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Section: Proteomicsmentioning

confidence: 99%

Section: Proteomicsmentioning

confidence: 99%

Section: Morphological Differences Between Single-sex and Bisexual Wormsmentioning

confidence: 99%

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Single-sex schistosomiasis: a mini review

Zhong

Jin

2023

Front. Immunol.

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“…The ability of a female worm to maintain egg production requires continuous stimulation by a mature male worm ( Loverde and Chen, 1991 ; Kunz, 2001 ). A single-sex infected female worm is characterized by incomplete development with stunting and an immature reproductive system, as the vitelline glands that produce the eggshell precursors and nutrients for the egg are not fully developed ( LoVerde et al, 2009 ; Zhong et al, 2022b ). Hence, single-sex infected worms do not cause serious damage to the host because underdeveloped worms cannot produce normal eggs ( Zhong et al, 2022a ).…”

Section: Micrornas Regulate the Development Of Schistosomesmentioning

confidence: 99%

Multifunctional Roles of MicroRNAs in Schistosomiasis

Zhong

Jin

2022

Front. Microbiol.

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Schistosomiasis is a parasitic disease that is caused by helminths of the genus Schistosoma. The dioecious schistosomes mate and lay eggs after undergoing a complex life cycle. Schistosome eggs are mostly responsible for the transmission of schistosomiasis and chronic fibrotic disease induced by egg antigens is the main cause of the high mortality rate. Currently, chemotherapy with praziquantel (PZQ) is the only effective treatment against schistosomiasis, although the potential of drug resistance remains a concern. Hence, there is an urgent demand for new and effective strategies to combat schistosomiasis, which is the second most prevalent parasitic disease after malaria. MicroRNAs (miRNAs) are small non-coding RNAs that play pivotal regulatory roles in many organisms, including the development and sexual maturation of schistosomes. Thus, miRNAs are potential targets for treatment of schistosomiasis. Moreover, miRNAs can serve as multifunctional “nano-tools” for cross-species delivery in order to regulate host-parasite interactions. In this review, the multifunctional roles of miRNAs in the growth and development of schistosomes are discussed. The various regulatory functions of host-derived and worm-derived miRNAs on the progression of schistosomiasis are also thoroughly addressed, especially the promotional and inhibitory effects on schistosome-induced liver fibrosis. Additionally, the potential of miRNAs as biomarkers for the diagnosis and treatment of schistosomiasis is considered.

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“…Most cases of schistosomiasis are treated with praziquantel (PZQ), with oxamaniquine (OXA) being used historically in limited populations (98). While evidence for the reduced efficacy of PZQ has been documented in natural populations (99)(100)(101)(102)(103)(104)(105); see also Cioli et al (106) for a review on this, the potential for PZQ-resistance to emerge has been demonstrated multiple times in laboratory settings (75,106). These laboratory-based studies found evidence that schistosomes can evolve variation in response to drug treatment after only a few generations of strong selection, but tend to reduce the fitness of the parasites in other ways (75,106).…”

Section: Genes Linked To Drug Resistance In Schistosomesmentioning

confidence: 99%

Prospects for genomic surveillance for selection in schistosome parasites

Nikolakis

Adams²,

Wade³

et al. 2022

Front. Epidemiol.

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Schistosomiasis is a neglected tropical disease caused by multiple parasitic Schistosoma species, and which impacts over 200 million people globally, mainly in low- and middle-income countries. Genomic surveillance to detect evidence for natural selection in schistosome populations represents an emerging and promising approach to identify and interpret schistosome responses to ongoing control efforts or other environmental factors. Here we review how genomic variation is used to detect selection, how these approaches have been applied to schistosomes, and how future studies to detect selection may be improved. We discuss the theory of genomic analyses to detect selection, identify experimental designs for such analyses, and review studies that have applied these approaches to schistosomes. We then consider the biological characteristics of schistosomes that are expected to respond to selection, particularly those that may be impacted by control programs. Examples include drug resistance, host specificity, and life history traits, and we review our current understanding of specific genes that underlie them in schistosomes. We also discuss how inherent features of schistosome reproduction and demography pose substantial challenges for effective identification of these traits and their genomic bases. We conclude by discussing how genomic surveillance for selection should be designed to improve understanding of schistosome biology, and how the parasite changes in response to selection.

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Schistosoma japonicum translationally controlled tumour protein, which is associated with the development of female worms, as a target for control of schistosomiasis

Cited by 7 publications

References 46 publications

Single-sex schistosomiasis: a mini review

Single-sex schistosomiasis: a mini review

Multifunctional Roles of MicroRNAs in Schistosomiasis

Prospects for genomic surveillance for selection in schistosome parasites

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