Schistosoma japonicum infection in the pig as a model for human schistosomiasis japonica

Johansen, Maria Vang; Bøgh, Henrik O.; Nansen, P.; Christensen, N. Ø.

doi:10.1016/s0001-706x(00)00103-0

Cited by 37 publications

(24 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is estimated that over 40 species of wild and domestic animals comprising 28 genera and seven orders can be infected (199). It was initially believed that those of public health importance were rats, dogs, pigs, sheep and goats, cattle, and water buffaloes (102,169,199). In China, however, dogs, pigs, rats, and goats are likely to contribute only minimally to overall transmission.…”

Section: Zoonotic Transmissionmentioning

confidence: 99%

“…In China, however, dogs, pigs, rats, and goats are likely to contribute only minimally to overall transmission. This is because until recently dogs were relatively uncommon in rural China (162), pigs are short-lived and are confined to pens within the communities and so have limited water contact (162), rats (field rats [Rattus norvegicus] and albino rats [R. norvegicus albus]) produce limited amounts of feces and harbor female S. japonicum worms with few viable eggs (66,89,92,102,144,199), and sheep and goats also have low fecal output and are present on the marshlands for only limited periods as they are sold at an early age as a food source (89,199).…”

Section: Zoonotic Transmissionmentioning

confidence: 99%

“…Bovines, particularly water buffaloes (Bubalus bubalis), play a major role in the transmission of S. japonicum in China (40,44,50,51,66,77,79,81,83,89,92,102,144,162,191,194,199,236). Significantly, the daily fecal output from a water buffalo (ϳ25 kg) has been estimated to be at least 100 times that produced by a human individual (250 g) (89,162).…”

Section: Zoonotic Transmissionmentioning

confidence: 99%

See 2 more Smart Citations

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

View full text Add to dashboard Cite

SUMMARY The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in China has invoked considerable global concern. The TGD will result in changes in the water level and silt deposition downstream, favoring the reproduction of Oncomelania snails. Combined with blockages of the Yangtze River's tributaries, these changes will increase the schistosomiasis transmission season within the marshlands along the middle and lower reaches of the Yangtze River. The changing schistosome transmission dynamics necessitate a comprehensive strategy to control schistosomiasis. This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. Drug delivery requires a substantial infrastructure to regularly cover all parts of an area of endemicity. This makes chemotherapy expensive and, as compliance is often low, a less than satisfactory control option. There is increasing disquiet about the possibility that PZQ-resistant schistosomes will develop. Consequently, as mathematical modeling predicts, vaccine strategies represent an essential component in the future control of schistosomiasis in China. With the inclusion of focal mollusciciding, improvements in sanitation, and health education into the control scenario, China's target of reducing the level of schistosome infection to less than 1% by 2015 may be achievable.

show abstract

Section: Zoonotic Transmissionmentioning

confidence: 99%

Section: Zoonotic Transmissionmentioning

confidence: 99%

Section: Zoonotic Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Schistosoma japonicum of the Anhui strain [21], were maintained by laboratory passage in Oncomelania hupensis snails and female NMRI mice housed at DBLInstitute for Health Research and Development. Cercariae were harvested as previously described [31].…”

Section: Parasitesmentioning

confidence: 99%

“…The number of eggs in the faeces, liver and caecum was determined as previously described [41]. Liver fibrosis was examined and scored as none = 0, mild = 1, moderate = 2, or severe = 3 depending on the number of worm nodules, lesions and levels of interlobular connective tissue related to fibrosis [21].…”

Section: Parasitological Techniquesmentioning

confidence: 99%

Cytokine mRNA profiles in pigs exposed prenatally and postnatally toSchistosoma japonicum

Techau¹,

Johansen²,

Aasted

et al. 2007

Vet. Res.

View full text Add to dashboard Cite

-The pig is a natural host for Schistosoma japonicum and a useful animal model of human infection. The aim of the present study was to assess the differences between the cytokine profiles in prenatally or postnatally S. japonicum exposed pigs. Seven prenatally exposed pigs, 7 postnatally exposed pigs and 4 uninfected control pigs were compared 27 weeks post exposure. Variables included worm burdens, tissue egg counts, liver pathology and mRNA levels of IL-2, IL-4, IL-10, IL-12, TNF-α, TGF-β1 and IFN-γ in the liver and the caecum, assessed by RT-PCR. Infection intensity and level of septal fibrosis were significantly higher in the postnatal group compared to the prenatal group (P < 0.05). A significant increase of IL-4 (P < 0.01), IL-10 (P < 0.01), IL-12 (P < 0.01) and TNF-α (P < 0.05) mRNA level was also observed in the caecum of prenatally infected animals compared to the control group (P < 0.01). The prenatal group showed higher levels of TGF-β1 in the liver compared with the postnatally infected group (P < 0.05) and the control group (P < 0.01). This suppressive immune response correlated with previously reported low hepatic pathogenesis in prenatally exposed pigs.swine / Schistosoma japonicum / cytokine / prenatal infection / postnatal infection

show abstract

Trematode Zoonoses

Singh¹,

Juyal²

2013

Parasitic Zoonoses

View full text Add to dashboard Cite

Schistosoma japonicum infection in the pig as a model for human schistosomiasis japonica

Cited by 37 publications

References 52 publications

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

Cytokine mRNA profiles in pigs exposed prenatally and postnatally toSchistosoma japonicum

Trematode Zoonoses

Contact Info

Product

Resources

About