Schistosoma haematobium infection in pregnancy

Siegrist, Dominik; Siegrist-Obimpeh, P.

doi:10.1016/0001-706x(92)90066-7

Cited by 62 publications

(34 citation statements)

References 5 publications

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“…Matched-pair analysis with a one-sided t test; a P value of Ͻ0.05 was considered significant (n ϭ 5 individual trophoblast preparations from distinct placentas). schistosomiasis in humans is associated with an increased risk of maternal anemia (5, 6), lower birth weight (7,8), and risk of low birth weight (LBW) and preterm delivery (8,39). In addition, we recently demonstrated that pregnant women infected with S. japonicum had increased proinflammatory cytokine levels in maternal peripheral, placental, and cord blood (17).…”

Section: Figmentioning

confidence: 99%

“…In humans, there is a relatively strong association between schistosome infection and an increased risk of maternal anemia (5,6). In addition, observational studies have revealed 4 to 18% lower birth weights for babies born to infected mothers (7,8), although clinical trials involving midgestational treatment for schistosomiasis have not demonstrated improved pregnancy outcomes (9). Schistosomiasis japonica is associated with multiple proinflammatory responsemediated morbidities in nonpregnant individuals (10,11), and inflammation is known to result in deleterious birth outcomes, including prematurity, intrauterine growth restriction (IUGR), and low birth weight (LBW) (12)(13)(14)(15)(16).…”

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confidence: 99%

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Schistosome Egg Antigens Elicit a Proinflammatory Response by Trophoblast Cells of the Human Placenta

et al. 2013

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f Schistosomiasis affects nearly 40 million women of reproductive age. Many of these women are infected while pregnant and lactating. Several studies have demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding how these antigens affect the developing fetus and placenta. To evaluate the impact of schistosomiasis on trophoblasts of the human placenta, we isolated primary trophoblast cells from healthy placentas delivered at term. These trophoblasts were placed in culture and treated with Schistosoma japonicum soluble egg antigens (SEA) or plasma from S. japonicum-infected pregnant women. Outcomes measured included cytokine production and activation of signal transduction pathways. Treatment of primary human trophoblast cells with SEA resulted in upregulation of the proinflammatory cytokines interleukin 6 (IL-6) and IL-8 and the chemokine macrophage inflammatory protein 1␣ (MIP-1␣). Cytokine production in response to SEA was dose dependent and reminiscent of production in response to other proinflammatory stimuli, such as Toll-like receptor 2 (TLR2) and TLR4 agonists. In addition, the signaling pathways extracellular signal-regulated kinase 1/2 (ERK1/2), Jun N-terminal protein kinase (JNK), p38, and NF-B were all activated by SEA in primary trophoblasts. These effects appeared to be mediated through both carbohydrate and protein epitopes of SEA. Finally, primary trophoblasts cocultured with plasma from S. japonicum-infected pregnant women produced increased levels of IL-8 compared to trophoblasts cocultured with plasma from uninfected pregnant women. We report here a direct impact of SEA on primary human trophoblast cells, which are critical for many aspects of a healthy pregnancy. Our data indicate that schistosome antigens can activate proinflammatory responses in trophoblasts, which might compromise maternal-fetal health in pregnancies complicated by schistosomiasis.

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Section: Figmentioning

confidence: 99%

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confidence: 99%

Schistosome Egg Antigens Elicit a Proinflammatory Response by Trophoblast Cells of the Human Placenta

et al. 2013

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“…Secondly, infestation of the placenta may cause still birth, abortion, premature onset of labor or low birthweight (Bittencourt et al 1980). In a prospective controlled trial Siegrist and Siegrist-Obimpeh (1992) in women infected with S. haematobium observed that women with urinary schistosomiasis, without necessarily presenting evidence of genital involvement, showed a significantly higher proportion of preterm deliveries and that the birthweight of their children was lower than that of non-infected women.…”

Section: Pathological and Gynecological Findingsmentioning

confidence: 99%

Genital manifestations of schistosomiasis mansoni in women: important but neglected

Feldmeier

Daccal

Martins

et al. 1998

Mem. Inst. Oswaldo Cruz

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“…There is extensive evidence in humans documenting both the transplacental transport of schistosome antigens (11,(13)(14)(15)(16) and consequent schistosome-specific adaptive immune responses in the cord blood of neonates of schistosome-infected mothers (12,16,17,29). Increased levels of schistosome antigen-specific IgE and B cells are found at birth in these children, compared to those of unexposed controls (12,29).…”

Section: Discussionmentioning

confidence: 99%

“…Vertical transmission of schistosomiasis in humans is not reported; therefore, this proinflammatory response is likely due to antigen trafficking across the placenta (11)(12)(13)(14)(15)(16)(17).…”

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confidence: 99%

Maternal Infection with Schistosoma japonicum Induces a Profibrotic Response in Neonates

et al. 2014

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fThe global burden of schistosomiasis is significant, with fibrosis a major associated morbidity and the primary cause of mortality. We have previously shown that schistosomiasis during pregnancy upregulates proinflammatory cytokines in the cord blood. In this study, we extend these findings to include a large panel of fibrosis-associated markers. We developed a multiplex beadbased assay to measure the levels of 35 proteins associated with fibrosis. Cord blood from 109 neonates born to mothers residing in an area of Schistosoma japonicum endemicity was assessed for these molecules. Ten mediators were elevated in the cord blood from schistosome-infected pregnancies, including insulin-like growth factor 1 (IGF-1), tumor growth factor ␤1 (TGF-␤1), connective tissue growth factor (CTGF), procollagen I carboxy-terminal propeptide (PICP), amino-telopeptide of type 1 collagen (ICTP), collagen VI, desmosine, matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 1 (TIMP-1), and TIMP-4. Many of these were also positively correlated with preterm birth (PICP, ICTP, MMP-2, TGF-␤1, desmosine, CTGF, TIMP-1). In addition, birth weight was 168 g lower for infants with detectable levels of CTGF than for those with CTGF levels below the level of detection. Maternal schistosomiasis results in upregulation of fibrosis-associated proteins in the cord blood of the neonate, a subset of which are also associated with adverse birth outcomes. As the first report of fibrosis-associated molecules altered in the newborn of infected mothers, this study has broad implications for the health of the fetus, stretching from gestation to adulthood.

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Schistosoma haematobium infection in pregnancy

Cited by 62 publications

References 5 publications

Schistosome Egg Antigens Elicit a Proinflammatory Response by Trophoblast Cells of the Human Placenta

Schistosome Egg Antigens Elicit a Proinflammatory Response by Trophoblast Cells of the Human Placenta

Genital manifestations of schistosomiasis mansoni in women: important but neglected

Maternal Infection with Schistosoma japonicum Induces a Profibrotic Response in Neonates

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