Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells

Wang, Zishu; Yu, Kaikai; Hu, Yudong; Su, Fang; Gao, Zengqiang; Hu, Tian; Yang, Yang; Cao, Xiangliao; Qian, Feng

doi:10.1016/j.bcp.2019.113673

Cited by 43 publications

(31 citation statements)

References 53 publications

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“…Consequently, a variety of anticancer drugs have recently been revealed to inhibit progression of tumor cells by inducing apoptosis. For instance, schisantherin ( 37 ) hindered proliferation of human gastric cancer cells by triggering apoptotic cell death. In the present study, activation of caspase-3/9 and PARP was closely associated with the apoptosis pathway.…”

Section: Discussionmentioning

confidence: 99%

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma

Zhang

Liu

et al. 2020

Oncol Rep

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Current treatments for esophageal squamous cell carcinoma (ESCC) have limited efficacy. Therefore, the development of novel therapeutic targets to effectively manage the disease and boost survival rates is imperative Neferine, a natural product extracted from Nelumbo nucifera (lotus) leaves, has been revealed to inhibit the growth of hepatocarcinoma, breast cancer and lung cancer cells. However, its effect on ESCC is unknown. In the present study, it was revealed that neferine exerted anti-proliferative effects in ESCC. It was also revealed that it triggered arrest of the G 2 /M phase and enhanced apoptosis of ESCC cell lines. Moreover, its ability to trigger accumulation of reactive oxygen species (ROS) and activate the c-Jun N-terminal kinase (JNK) pathway was demonstrated. Further study revealed how N-acetyl cysteine (NAC), a ROS inhibitor, attenuated these effects, demonstrating that ROS and JNK inhibitors mediated a marked reversal of neferine-triggered cell cycle arrest and apoptosis in ESCC cells. Finally, it was revealed that neferine was involved in the inhibition of Nrf2, an antioxidant factor. Collectively, these findings demonstrated the antitumor effect of neferine in ESCC, through the ROS-mediated JNK pathway and inhibition of Nrf2, indicating its potential as a target for development of novel and effective therapeutic agents against ESCC.

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Section: Discussionmentioning

confidence: 99%

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma

Zhang

Liu

et al. 2020

Oncol Rep

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“…Moreover, schisandrin B can inhibit proliferation and aberrant mitosis by the downregulation of cyclin D1 mRNA expression [34]. Schisantherin A induced cell apoptosis and cell cycle arrest at G2/M phase, inhibited cell migration, induced reactive oxygen species (ROS)dependent Jun N-terminal kinase (JNK) phosphorylation with higher ROS production, and suppressed the expression of Nrf2 in in vitro studies [35].…”

Section: Discussionmentioning

confidence: 99%

Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain

et al. 2020

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Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32–0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36–0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28–0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34–0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39–0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.

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“…MKN45 cells have been widely used as tumor cells for gastric cancer studies. 48,49 The effect of free PTX and the two NLCs on the inhibition of tumor cells and cytotoxicity of healthy cells were investigated by CCK8 assay. It was found that GX1-PTX-NLCs had the strongest inhibitory effect (higher than that of PTX-NLCs and PTX) on Co-HUVEC cells when the concentration of PTX was 80 μmol/mL.…”

Section: Discussionmentioning

confidence: 99%

<p>A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity</p>

Jian¹,

Zhao²,

Cao³

et al. 2020

DDDT

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The aim of this study was to develop a GX1-modified nanostructured lipid carrier (NLCs) and to evaluate its ability to improve the anti-gastric cancer tumor effects of paclitaxel (PTX). Main Methods: The GX1-modified NLCs were synthesized and loaded with PTX (GX1-PTX-NLCs) by emulsion solvent evaporation technique. The anti-tumor activity and pharmacodynamics were then evaluated by in vitro cell studies and animal experiments. Key Findings: The GX1-modified NLCs were successfully synthesized and confirmed by 1 H NMR and MALDI-TOF-MS. PTX-loaded NLCs produced particles with average size distribution less than or equal to 222 nm and good drug loading and entrapment efficiency. In vitro studies demonstrated that GX1-PTX-NLCs had a more obvious inhibitory effect on Co-HUVEC cells than PTX and unmodified PTX-NLCs. The cellular uptake results also showed that GX1-PTX-NLCs were largely concentrated in Co-HUVEC cells, and the uptake rates of GX1-PTX-NLCs in Co-HUVEC were higher than those of the free drug and the PTX-NLC. In vivo studies demonstrated that GX1-PTX-NLCs possess strong anti-tumor effect and showed higher tumor growth inhibition and lower toxicity in nude mice. Significance: These results suggest that GX1-modified NLCs enhanced the anti-tumor activity of PTX and reduced its toxicity effectively. GX1-PTX-NLCs may be considered as a potent drug delivery system for therapy of gastric cancer.

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Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells

Cited by 43 publications

References 53 publications

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma

Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain

<p>A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity</p>

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