Schisanlactone B, a new triterpenoid from a .

Liu, Jia-Sen; Huang, Mei-Fen; Ayer, William A.; Bigam, Glen

doi:10.1016/s0040-4039(00)81923-1

Cited by 39 publications

(32 citation statements)

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“…Twenty-two known analogous (7-28) were identified by analysis of their spectroscopic data with the reported data for xuetongsu (schisanlactone E, 7) 10.8 g (Liu and Huang, 1991), kadnanolactone A (8) 5.0 mg (Yang et al, 2010), schisanlactone B (9) 25.0 mg (Liu et al, 1983), kadsuphilactone B (10) 6.8 mg (Shen et al, 2005), schisanbilactone A (11) 4.0 mg (Ma et al, 2009), cycloartenone (12) 2.5 g (Pavanasisivam and Sultanbawa, 1973), schisandronic acid (13) 18.2 mg (Li et al, 2003), heteroclic acid (14) 5.6 mg (Wang et al, 2006b), changnanic acid (15) 18.0 mg (Liu and Huang, 1991), heteroclitalactone C (16) 5.5 mg (Wang et al, 2006b), heteroclitalactone D (17) 42.0 mg (Wang et al, 2006b), heteroclitalactone F (18) 7.0 mg (Wang et al, 2006b), heteroclitalactone G (19) 22.0 mg (Wang et al, 2007), heteroclitalactone I (20) 6.5 mg (Wang et al, 2007), heteroclitalactone K (21) 12.5 mg (Wang et al, 2007), heteroclitalactone L (22) 15.3 mg (Wang et al, 2007), heteroclitalactone M (23) 17.3 mg (Wang et al, 2007), sorghumol (24) 12.9 mg (Han et al, 2008), β-sitosterol (25) 100 mg (Chaturvedula and Prakash, 2012), daucosterol (26) 10.0 mg (Rahmana et al, 2009), 6β-hydoxysitostenone (27) 7.6 mg (Liang et al, 2015), and a steroid, trihydoxy pregnene (28) 13.0 mg (Deng et al, 2010). Their structures are presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Xuetonglactones A–F: Highly Oxidized Lanostane and Cycloartane Triterpenoids From Kadsura heteroclita Roxb. Craib.

Shehla

Cao

et al. 2020

Front. Chem.

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Xuetonglactones A-F (1-6), six unreported highly oxidized lanostane-and cycloartane-type triterpenoids along with 22 known scaffolds (7-28) were isolated from the stems of Kadsura heteroclita (Roxb.) Craib. Compared with previous congeners, xuetonglactone A (1), possesses an unprecedented 20,21-α-epoxide, and xuetonglactone D (4) features an unusual 19-α-hydroperoxyl moiety. The structures and the absolute configurations of the compounds were established by extensive one-and two-dimensional NMR, and electronic circular dichroism (ECD) spectroscopic analysis, with those of 1 and 5 confirmed by single-crystal X-ray diffraction technique. Compounds 1 and 2 exhibited inhibition of iNOS activity in LPS-induced macrophages with IC 50 values of 22.0, and 17.0 µg/mL, respectively. While compounds 6, 7, 8, and 24 showed potent cytotoxic activities against human cervical cancer cell lines (HeLa) with the IC 50 values of 4.0, 5.8, 5.0, and 6.4 µM, and against human gastric cancer cells (BGC 823) with the IC 50 values of 2.0, 5.0, 2.5, and 2.0 µM, respectively. Moreover, plausible biogenetic pathways of (1-6) were also proposed.

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Section: Resultsmentioning

confidence: 99%

Xuetonglactones A–F: Highly Oxidized Lanostane and Cycloartane Triterpenoids From Kadsura heteroclita Roxb. Craib.

Shehla

Cao

et al. 2020

Front. Chem.

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“…yunnanensis A. C. Smith, a plant indigenous to Yunnan Province of China. In this paper we describe the isolation of four novel nortriterpenoids, henridilactones AϪD (1Ϫ4), together with eight known triterpenoids, schiprolactone A (7), [7] schisanlactone A (8), [8] schisanlactone B (9), [9] juncoside I (10), [10] nigranoic acid (11), [11] schizandronic acid (12), [12] changnic acid (13) [13] and kadsuric acid (14), [14] and elucidation of the structures of the new compounds by spectroscopic analysis. Henridilactones AϪD are members of a unique unusual highly oxidized cycloartane skeletal class, structurally related to micrandilactone A (5), [5] which was firstly isolated from S. micrantha.…”

Section: Introductionmentioning

confidence: 99%

Four Novel Nortriterpenoids Isolated from Schisandra henryi var. yunnanensis

Shen

Wei

et al. 2004

Eur J Org Chem

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Four novel nortriterpenoids, henridilactones A−D (1−4), members of a very rare highly oxidized cycloartane skeletal class with a biosynthetically modified eight‐membered ring D, were isolated from the leaves and stems of Schisandra henryi var. yunnanensis. Their structures were elucidated using extensive spectroscopic techniques including 1D and 2D NMR spectra. Eight known triterpenoids were also isolated from the same source. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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“…Structures of compounds 1-9. DOI: 10.3109/13880209.2013.818039 five known triterpenoids: micranoic acid B (5) (Li et al, 2003), lancifodilactone H (6) , coccinic acid (7) (Li & Xue, 1986), schisanlactone B (8) (Liu et al, 1983) and anwuweizonic acid (9) (Liu et al, 1988a). Their structures are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Liu

et al. 2013

Pharmaceutical Biology

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Context: The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited. Objective: Elucidation of the cytotoxic constituents of S. pubescens was performed. Methods: Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines. Results: Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (À)-gomisin L 2 (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI 50 values of 11.83-35.65 mM. Conclusion: The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.

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Schisanlactone B, a new triterpenoid from a .

Cited by 39 publications

References 1 publication

Xuetonglactones A–F: Highly Oxidized Lanostane and Cycloartane Triterpenoids From Kadsura heteroclita Roxb. Craib.

Xuetonglactones A–F: Highly Oxidized Lanostane and Cycloartane Triterpenoids From Kadsura heteroclita Roxb. Craib.

Four Novel Nortriterpenoids Isolated from Schisandra henryi var. yunnanensis

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

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