Schisandrin C Ameliorates Learning and Memory Deficits by Aβ_1-42-induced Oxidative Stress and Neurotoxicity in Mice

Abstract

Schisandrin C (SCH-C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize the effect of SCH-C on memory impairment and further research on pathological changes in Aβ -induced Alzheimer's disease mice. Mice were administration with SCH-C daily for 5 days in the lateral cerebral ventricles using sterotaxically implanted cannula. Cognitive functions were assessed by Y-maze test, active avoidance test and Morris water maze test in all groups, and the level of Aβ and neuronal injury induced by Aβ were reversed remarkably following SCH-C treatment compared with sham group; meanwhile the impairment of short-term or working memory was dramatically improved. In addition, SCH-C significantly inhibited total cholinesterase (ChEtotal), and increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activity glutathione (GSH) levels in the hippocampus and cerebral cortex. It can be speculated that SCH-C offers protection against Aβ -induced dysfunction in learning and memory by inhibiting ChEtotal and its antioxidant action. Copyright © 2015 John Wiley & Sons, Ltd.

The potential health effects of dietary phytoestrogens

“…Different lignans have shown positive effects on cognitive performance and markers of Alzheimer's disease in mice (Um et al , ; Giridharan et al , ; Hu et al , ; Jeong et al , ; Li et al , ; Mao et al , ). In observational studies in humans, higher dietary intake of lignans is associated with better cognitive function (Franco et al , ; Kreijkamp‐Kaspers et al , ; Greendale et al , ; Nooyens et al , ), while coumestrol ingestion was unrelated to cognitive performance (Greendale et al , ).…”

Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers

“…We also observed a remarkable decrease of THP-1 macrophage GSH levels upon lignan treatment. While our earlier studies with monocytic THP-1 cells show glutathione pool suppression by the lignans [25], earlier work has indicated that schisandrin C may increase GSH levels in the central nervous system [41] and several related lignans may prevent oxidant-induced GSH depletion in liver [17]. Based on these findings, it seems obvious that the effects of dibenzocyclooctadiene lignans on mammalian cell glutathione metabolism are dependent on target cells or tissues as well as the physiological conditions.…”

Schisandra chinensis extract ameliorates age‐related muscle wasting and bone loss in ovariectomized rats

“…Antioxidant supplementation delays aging by reducing the expression of inflammatory molecules (Giovannelli et al, ; Y. H. Lee et al, ). S. chinensis extracts and compounds exhibit anti‐inflammatory and antioxidant effects (Mao et al, ; Oh et al, ; Takanche et al, ). In a previous study, we reported that the effects of Schisandrin C and Gomisin A compound isolated from S. chinensis exhibited potential antioxidative mechanisms and antiaging properties in C2C12 skeletal muscle and HDF cells (Kim et al, ; Kim & Yi, ).…”