Schisandra Fruit Vinegar Lowers Lipid Profile in High‐Fat Diet Rats

Yuan, Rui; Sun, Guifan; Gao, Jiaqi; Yu, Zhanyang; Yu, Chih Teng; Wang, Chunmei; Sun, Jia; He, Li; Chen, Jianguang

doi:10.1155/2020/7083415

Cited by 6 publications

(6 citation statements)

References 35 publications

(37 reference statements)

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“…Beheshti et al reported that vinegar consumption reduced TG, TC and LDL-C levels in hyperlipidemia patients, and had no significant influence on HDL-C level ( Beheshti et al, 2013 ). Another study reported that schisandra vinegar significantly reduced serum TG, TC and LDL-C content, and increased HDL-C content in high-fat diet rats ( Yuan et al, 2020 ). In present study, SAV has no effects on blood lipids in normal mice.…”

Section: Resultsmentioning

confidence: 99%

Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome

Xia,

Kang,

Qiang

et al. 2024

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome

Xia,

Kang,

Qiang

et al. 2024

Current Research in Food Science

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“…Fruit vinegar's blood-lipid-lowering benefits can be attributed, in large part, to its antioxidant and antiinflammatory properties (14,15). However, because different sources of carbs and microorganisms are used during the fermentation process, the bioactivities and health benefits of vinegar may vary (16). Currently, red dates, black dates, and green dates are the primary sources of jujube vinegar (16,17).…”

Section: Introductionmentioning

confidence: 99%

“…However, because different sources of carbs and microorganisms are used during the fermentation process, the bioactivities and health benefits of vinegar may vary (16). Currently, red dates, black dates, and green dates are the primary sources of jujube vinegar (16,17). Caffeic acid, ferulic acid, flavonoid, and carotenoid comprise the bulk of jujube vinegar's biological functions (18,19).…”

Section: Introductionmentioning

confidence: 99%

Deciphering the mechanism of jujube vinegar on hyperlipoidemia through gut microbiome based on 16S rRNA, BugBase analysis, and the stamp analysis of KEEG

Guo-feng

2023

Front. Nutr.

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BackgroundGrowing data indicate that the gut microbiome may contribute to the rising incidence of hyperlipoidemia. Jujube vinegar lowers lipids, protects the liver, and reduces oxidant capacity, however, it is unknown whether this is due to the gut flora. To further research the role of the gut microbiome in treating hyperlipidemia with jujube vinegar, we looked into whether the action of jujube vinegar is related to the regulation of the gut microbiome.MethodThirty male ICR mice were used. The control group (CON), the high-fat diet (HFD) group, and the vinegar group (VIN) each consisted of ten female ICR mice fed consistently for eight weeks. For each treatment, we kept track of body mass, liver index, blood lipid levels, and oxidative stress state. We also analyzed mouse feces using high-throughput 16srRNA sequencing to examine the relationship between jujube vinegar’s hypolipidemic effect and antioxidant activity and how it affects the gut microbiome.ResultsJujube vinegar reduced body weight by 19.92%, serum TC, TG, and LDL-C by 25.09%, 26.83%, and 11.66%, and increased HDL-C by 1.44 times, serum AST and ALT decreased by 26.36% and 34.87% respectively, the blood levels of SOD and GSH-Px increased 1.35-fold and 1.60-fold, respectively. While blood MDA decreased 33.21%, the liver’s SOD and GSH-Px increased 1.32-fold and 1.60-fold, respectively, and the liver’s MDA decreased 48.96% in HFD mice. The gut microbiome analysis revealed that jujube vinegar increased the intestinal microbial ASV count by 13.46%, and the F/B (Firmicutes/Bacteroidota) ratio by 2.08-fold in high-fat diet mice, and the proportion was significantly inversely correlated with TC, TG, and LDL-C and positively correlated with HDL-C. Biomarker bacteria in the vinegar group included Lactobacillaceae and Lactobacillus, which correlated favorably with HDL-C, SOD, and GSH-Px and negatively with LDL-C, TC, and TG. Jujube vinegar increased the abundance of the Aerobic, Contains Mobile Elements, and Facultative Aerobic by 2.84 times, 1.45 times, and 2.40 times, while decreased the abundance of Potential pathogens by 44.72%, according to the BugBase study. The KEGG analysis showed that jujube vinegar was predominantly reflected in the biological process of gene function and related to signal transduction pathways, including glucagon signaling system, HIF-1 signaling pathway, adipocytokine signaling pathway, amino sugar, and nucleotide sugar metabolism, and so forth.ConclusionBased on these findings, jujube vinegar may reduce hyperlipoidemia by controlling the gut microbiome and enhancing antioxidant capacity.

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“…The improved glycemic response is attributed to acetic acid, which has been demonstrated to reduce the digestive capacity of disaccharidases in vitro [7] and to enhance the clearance of glucose from the blood stream into muscle in vivo [4,8]. The lipid lowering mechanism of vinegar may relate to the upregulation of PPAR-α and its target genes acyl-CoA oxidase 1 and carnitine palmitoyltransferase I, and enhanced β-oxidation in the liver [9,10]. Possibly, bioactives in vinegar in concert with acetic acid initiate these effects [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The lipid lowering mechanism of vinegar may relate to the upregulation of PPAR-α and its target genes acyl-CoA oxidase 1 and carnitine palmitoyltransferase I, and enhanced β-oxidation in the liver [9,10]. Possibly, bioactives in vinegar in concert with acetic acid initiate these effects [9,10].…”

Section: Introductionmentioning

confidence: 99%

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

et al. 2021

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Daily vinegar ingestion has been linked to improved glycemic control, but recent data suggest a separate unexplored role for vinegar in mental health. Utilizing a placebo-controlled, parallel arm study design, this 4-week trial examined the impact of daily vinegar ingestion on mood states and urinary metabolites in healthy college students. Participants were randomized to the vinegar group (VIN: n = 14; 1.5 g acetic acid/day as liquid vinegar) or the control group (CON: n = 11; 0.015 g acetic acid/day as a pill) with no change to customary diet or physical activity. At baseline and at study week four, participants completed the Profile of Mood States (POMS) and the Center for Epidemiological Studies-Depression (CES-D) questionnaires and provided a first-morning urine sample for targeted metabolomics analyses. The change in both POMS depression scores and CES-D scores differed significantly between groups favoring improved affect in the VIN versus CON participants after four weeks. Metabolomics analyses pre and post-intervention suggested metabolite alterations associated with vinegar ingestion that are consistent for improved mood, including enzymatic dysfunction in the hexosamine pathway as well as significant increases in glycine, serine, and threonine metabolism. These data warrant continued investigation of vinegar as a possible agent to improve mood state.

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Schisandra Fruit Vinegar Lowers Lipid Profile in High‐Fat Diet Rats

Cited by 6 publications

References 35 publications

Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome

Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome

Deciphering the mechanism of jujube vinegar on hyperlipoidemia through gut microbiome based on 16S rRNA, BugBase analysis, and the stamp analysis of KEEG

Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

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