Schisandra B, a representative lignan from <i>Schisandra chinensis</i>, improves cisplatin‐induced toxicity: An in vitro study

Hu, Jun‐Nan; Wang, Yi‐ming; Zhang, Hao; Li, Huiping; Wang, Zi; Han, Mei; Ren, Shengxiang; Tang, Shan; Jiang, Shuang; Li, Wei

doi:10.1002/ptr.7644

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Results were represented by mean±SD of 3 separate assays. P<0.05 stood for statistical significance [20,21].…”

Section: Discussionmentioning

confidence: 99%

Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Ding

et al. 2023

Aging

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To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury. This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded liver tissue sections were prepared, later, BAX/BCL-2 protein expression was observed by HE, Sirius red, TUNEL and immunofluorescence to detect apoptotic injury and α-SMA/TGF-β protein expression to detect fibrosis, and liver inflammation-related protein NF-KB was detected. HE and TUNEL staining showed that Rg3 reduced necrotic cells and fibrosis in liver-injured mice, Rg3 increased anti-inflammatory cytokine IL-18 and reduced TNF-α, IL-1β and IL-6 expression. Conclusion: Ginsenoside Rg3 can effectively antagonize D-gal's role in mouse liver injury, and its mechanism may be associated with regulating inflammatory pathway by Rg.

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“…Results were represented by mean±SD of 3 separate assays. P<0.05 stood for statistical significance [20,21].…”

Section: Discussionmentioning

confidence: 99%

Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Ding

et al. 2023

Aging

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Schisandrin B protect inner hair cells from cisplatin by inhibiting celluar oxidative stress and apoptosis

Li,

Liu,

Chen

et al. 2024

Toxicology in Vitro

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Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis

Xu,

Deng,

Man

et al. 2024

DDDT

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Objective This study investigates the targets, pathways, and mechanisms of Schisandrin B (Sch B) in alleviating renal ischemia-reperfusion injury (RIRI) using RNA sequencing and network pharmacology. Methods The effects of Sch B on RIRI were assessed using hematoxylin-eosin (HE) and periodic acid-Schiff (PAS) staining, along with measurements of blood creatinine and urea nitrogen (BUN). Differential gene expression in mouse models treated with RIRI and Sch B+RIRI was analyzed through RNA-Seq. Key processes, targets, and pathways were examined using network pharmacology techniques. The antioxidant capacity of Sch B was evaluated using assays for reactive oxygen species (ROS), mitochondrial superoxide, and JC-1 membrane potential. Molecular docking was employed to verify the interactions between key targets and Sch B, and the expression of these targets and pathway was confirmed using qRT-PCR, Western blot, and immunofluorescence. Results Sch B pre-treatment significantly reduced renal pathological damage, inflammatory response, and apoptosis in a mouse RIRI model. Pathological damage scores dropped from 4.33 ± 0.33 in the I/R group to 2.17 ± 0.17 and 1.5 ± 0.22 in Sch B-treated groups (p < 0.01). Creatinine and BUN levels were also reduced (from 144.6 ± 21.05 µmol/L and 53.51 ± 2.34 mg/dL to 50.44 ± 5.61 µmol/L and 17.18 ± 0.96 mg/dL, p < 0.05). Transcriptomic analysis identified four key targets (AKT1, ALB, ACE, CCL5) and the PI3K/AKT pathway. Experimental validation confirmed Sch B modulated these targets, reducing apoptosis and oxidative stress, and enhancing renal recovery. Conclusion Sch B reduces oxidative stress, inflammation, and apoptosis by modulating key targets such as AKT1, ALB, ACE, and CCL5, while activating the PI3K/AKT pathway, leading to improved renal recovery in RIRI.

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Schisandra B, a representative lignan from Schisandra chinensis, improves cisplatin‐induced toxicity: An in vitro study

Cited by 3 publications

References 49 publications

Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Schisandrin B protect inner hair cells from cisplatin by inhibiting celluar oxidative stress and apoptosis

Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis

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