Schiff Bases: A Versatile Pharmacophore

Abstract

Schiff bases are condensation products of primary amines with carbonyl compounds gaining importance day by day in present scenario. Schiff bases are the compounds carrying imine or azomethine (-C=N-) functional group and are found to be a versatile pharmacophore for design and development of various bioactive lead compounds. Schiff bases exhibit useful biological activities such anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, antiglycation, and antidepressant activities. Schiff bases are also used as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. The present review summarizes information on the diverse biological activities and also highlights the recently synthesized numerous Schiff bases as potential bioactive core.

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C17H12N2O3

“…Some Schiff bases show biological activities such as anti-inflammatory, antimicrobial, anticonvulsant, anticancer, analgesic etc. [2][3][4]. And also, their metal complexes often exhibit antibacterial, antiviral, fungicidal or antitubarculoral activity [5,6].…”

“…S(6) and S(5) loops are created by the intramolecular H bonds C7-H7· · · O3 and C10-H10· · · N2, respectively [9]. There is also π-π stacking which contributes to stabilization between the ring centroids of Cg(1)-Cg (2) [distance between ring centroids is 3.695(2) Å with symmetry code: 1−x, 1−y, 1−z where Cg(1) belongs to the C1-C6 ring and Cg(2) to C8/C9/C14/C15/C16/C17].…”

Biological Applications of Tryptamine Schiff Base Derivatives

“…Compounds with carbon-nitrogen double bond content know as imine has been widely documented for their fascinated properties. Imine or Schiff bases are the end products of the reaction between a primary amine with a carbonyl [1]. This condensation product was reported for the first time by the Swedish Hugo Schiff in 1864 [2].…”

Charactrisation of Synthesized Ni (Ii), Cu (Ii) Metal Complexes and Antioxidant, Antimicrobial Study

“…This fact had been result in infinite publication in coordination chemistry. So researcher infatuated to use it as medicinal power house, as anti-cancer, antibacterial, antiviral, DNA-cleavage, antitumor, anti-oxidant, [2][3][4][5][6][7] In continuation of our earlier work [8] in this study we synthesized complexes of Ni(II), and Cu and characterized by different spectral methods, also evaluated for antioxidant and microbial activity.…”