Schiff base rare earth metal complexes: Studies on functional, optical and thermal properties and assessment of antibacterial activity

Andiappan, Kavitha; Sanmugam, Anandhavelu; Easwaramoorthy, D.; Karuppasamy, K.; Vikraman, Dhanasekaran

doi:10.1016/j.ijbiomac.2018.11.251

Cited by 45 publications

(10 citation statements)

References 38 publications

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“…Nanomedicines can destroy or inhibit the growth of genes by infiltrating the cell walls of bacteria, causing the condensation of DNA molecules and preventing reproduction or growth [18]. The antimicrobial activities of nanomaterials vary dramatically depending on the morphological and physicochemical characteristics of the nanomaterials [19,20]. In addition, nanomaterials consisting of metal ions can be directly linked to the thiol groups of the cysteine amino acid rather than to the sulfur of proteins, inducing a huge alteration of the active sites and leading to cell mortality [4,21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Properties of Novel ZnMn2O4–Chitosan Nanocomposites

et al. 2019

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The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol–gel one-pot reaction was used to synthesize hybrid composites of hausmannite–chitosan (Mn3O4–CS) and its innovative derivative zinc manganese oxide–chitosan (ZnMn2O4–CS). Fixed amounts of CS with different metal matrix w/v ratios of 0.5%, 1.0%, 1.5%, and 2.0% for Mn and Zn precursors were used to synthesize ZnMn2O4–CS hybrid composites. X-ray diffraction analysis indicated the formation of polycrystalline tetragonal-structured ZnMn2O4 with a CS matrix in the hybrids. Fourier-transform infrared spectroscopic analysis confirmed the formation of ZnMn2O4–CS hybrids. Detailed investigations of the surface modifications were conducted using scanning electron microscopy; micrographs at different magnifications revealed that the composites’ surface changed depending on the ratio of the source materials used to synthesize the ZnMn2O4–CS hybrids. The antibacterial activity of the Mn3O4–CS and ZnMn2O4–CS composites was tested against various bacterial species, including Bacillus subtilis, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The zone of inhibition and minimum inhibitory concentration values were deduced to demonstrate the efficacy of the ZnMn2O4–CS nanocomposites as antibacterial agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Properties of Novel ZnMn2O4–Chitosan Nanocomposites

et al. 2019

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“…[ 74 ] Moreover, the variety of functional groups in the formed heteroleptic complexes enhances the interactions of the metal ions with cell components. [ 5 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Abdallah

Zaki

Mahmoud

et al. 2021

Applied Organom Chemis

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In the field of transition metal chemistry, the development of transition metal‐based drugs for the treatment of diseases such as cancer or microbial infections with minimization of adverse effects and drug resistance constitutes an active area of research. Herein, eight novel nanosized heteroleptic complexes of cocaine/TMEDA with the formula [M(COC)(TMEDA)Cly(OH2)z]nCl·xH2O (M = Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II); COC = cocaine; TMEDA = N,N,N′,N′‐tetramethylethylenediamine, y = 1–2; z = 0–1; n = 0–1; and x = 0–2) were synthesized and structurally characterized via elemental analysis, molar conductivity, mass spectrometry, and spectroscopic and microscopic techniques. The thermal properties and kinetic thermodynamic parameters of the synthesized complexes were also studied. The geometry and electronic structures were investigated via density functional theory (DFT) calculations. The antiproliferative activity of the complexes on HepG‐2 and MCF‐7 cancer cell lines was quantified via MTT assay. The Fe(III) and Cd(II) complexes exhibited promising cytotoxic activities against the HepG‐2 and MCF‐7 cancer cell lines, respectively, with minimum effect on HFB4 human normal cells. Further molecular mechanistic studies were performed on the Cd(II) complex to inspect its influence on different cancer pathophysiology‐related processes in the MCF‐7 cell line including metastasis, apoptosis, and cellular oxidative stress and on the cellular levels of the human tumor suppressor nuclear proteins p21 and p27. The results revealed that the Cd(II) complex is a promising anticancer agent that acts through several molecular mechanisms with minimum effect on the normal cells and with additional antimetastatic properties. Furthermore, the antibacterial and antifungal activities of the prepared complexes were investigated.

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“…Since the synthesis of Ln(C 5 H 5 ) 3 by Wilkinson and Birmingham in 1954, [1] the investigation of rare earth element organic complexes has experienced enormous growth in the past two decades [2] . The organo‐lanthanide complexes find various applications, due to their optical properties, [3] magnetic behavior, [4] and antibacterial activity [5] . The organo‐lanthanide complexes, in particular, have attracted organic chemists.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and DFT studies of Praseodymium (III) Octanoyl‐DL‐aminocarboxylate Complexes

et al. 2022

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Rare‐earth amino acid complexes have attracted much attention for their unique properties and potential applications in various fields. In this study, we synthesized and characterized the praseodymium(III) complexes with octanoyl‐DL‐alaninates (Pr(oct‐ala)3), octanoyl‐DL‐phenylalaninate (Pr(oct‐phe)3), and octanoyl‐DL‐serinates (Pr(oct‐ser)3) ligands. Elemental analysis, NMR, and FT‐IR spectra confirmed the elemental content, and functional groups information in the synthesized complexes. The XRD profile demonstrated the amorphous structure of praseodymium(III) complexes. Polarized optical microscopy gave insight into the liquid crystal properties of the praseodymium(III) complexes. UV‐Vis and PL emission spectra illustrated the excellent optical absorption properties and emitted white light. DFT calculation confirming the chelating bidentate mode of praseodymium(III) complexes. The atoms in molecules theory calculated the topological properties of praseodymium(III) complexes. The ▿2ρ and ρc values are in the range of 0.1966–0.2019 a.u and 0.0583–0.0608 a.u, respectively, illustrating closed‐shell interactions between ligands and Pr3+.

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Schiff base rare earth metal complexes: Studies on functional, optical and thermal properties and assessment of antibacterial activity

Cited by 45 publications

References 38 publications

Synthesis and Antibacterial Properties of Novel ZnMn2O4–Chitosan Nanocomposites

Synthesis and Antibacterial Properties of Novel ZnMn2O4–Chitosan Nanocomposites

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d‐block metal ions

Synthesis, Characterization, and DFT studies of Praseodymium (III) Octanoyl‐DL‐aminocarboxylate Complexes

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