Schiff Base Metal Complexes as Antimicrobial and Anticancer Agents

Jain, Shruti; Rana, Manish; Sultana, Razia; Mehandi, Rabiya; Uddin, Rahis

doi:10.1080/10406638.2022.2117210

Cited by 15 publications

(9 citation statements)

References 111 publications

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“…They offer exceptional structural and synthetic flexibility, along with finetuning capabilities. [4][5][6] Schiff base ligands, in particular, exhibit notable bioactivity across a wide range of biomolecular applications. [7][8][9][10][11][12] Their physiological activities are further enhanced upon complexation with metal ions, 13,14 and the diverse oxidation states and ligand structures of metal atoms play a crucial role in altering the kinetic and thermodynamic reactivity of compounds towards biological receptors.…”

Section: Introductionmentioning

confidence: 99%

“…Schiff base ligands, often referred to as “privileged bases,” provide a molecular framework for various organic substrates due to their ability to form stable coordination complexes through azomethine nitrogen (–CH=N–). They offer exceptional structural and synthetic flexibility, along with fine‐tuning capabilities 4–6 . Schiff base ligands, in particular, exhibit notable bioactivity across a wide range of biomolecular applications 7–12 .…”

Section: Introductionmentioning

confidence: 99%

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Unveiling the biomedical potential of thiophene‐derived Schiff base complexes: A comprehensive study of synthesis, spectral characterization, antimicrobial efficacy, antioxidant activity, and computational insights

Bhardwaj,

Dubey,

Tufail

et al. 2024

Applied Organom Chemis

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In our pursuit of designing potent bioactive compounds, we synthesized six novel tellurium (IV) complexes through the condensation of 5‐methyl‐2‐thiophene carboxaldehyde and p‐nitroaniline. These compounds underwent rigorous investigation using various analytical techniques (TGA, SEM, EDAX, and powder XRD) and spectral analyses (NMR, mass spectrometry, UV–Vis, and FTIR). Spectroscopic analysis suggested an octahedral geometry for the complexes, revealing chelation through the thiophene sulfur and azomethine nitrogen atoms. Thermal analysis indicated a three‐step degradation process, ultimately leaving behind metal oxide as the end product. We conducted in‐vitro antimicrobial screening using the broth micro‐dilution method, highlighting the significant antimicrobial and antioxidant properties of complexes 3c and 3d, as well as the potent antimicrobial activity of 3b and 3f against various bacterial strains, including Candida albicans. To further substantiate our findings, we performed advanced computational analyses, including molecular docking, pharmacophore modeling, DFT, MESP, and ADMET studies. Molecular docking validated our antimicrobial results, whereas pharmacophore models enhanced our understanding of molecular interactions with proteins, potentially identifying novel bioactive compounds. Furthermore, DFT and MESP investigations underscored the superior biological efficacy of tellurium (IV) complexes over thiophene‐derived ligands, emphasizing their potential as therapeutic agents. ADMET analysis revealed their favorable profile as precursors for drug development with minimal adverse effects. In summary, our research seamlessly integrates experimental and theoretical aspects, offering innovative insights into drug design and potential applications in pharmaceuticals. This study represents a significant milestone, paving the way for future advancements in the field of pharmaceutical science.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unveiling the biomedical potential of thiophene‐derived Schiff base complexes: A comprehensive study of synthesis, spectral characterization, antimicrobial efficacy, antioxidant activity, and computational insights

Bhardwaj,

Dubey,

Tufail

et al. 2024

Applied Organom Chemis

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“…13 Many SBs are known to be used in a broad range of fields, including electroluminescence, 14-17 luminescence, [18][19][20] energy materials, 21 analytical chemistry, 22 food industry, 23 catalysis, [24][25][26] dye industries, 27,28 manufacturing of polymer-based substances, 29,30 use as detectors, [31][32][33] organic optoelectronic substances, 34,35 and pharmacological agents. 36 Pharmacological applications include anti-inflammatory, 37,38 antitumor, 39,40 anti-convulsant, [41][42][43][44] anti-fungal, 44-46 painkillers, 47 anti-bacterial, [48][49][50] anti-malarial, 51,52 antiviral, [53][54][55][56][57] anti-helminthic, 58,59 anti-oxidants, [60][61][62] and DNA interaction 63 and further along (Scheme 2). Because of their DNA-binding characteristics, SB metal complexes have garnered significant interest over the past 10 years.…”

Section: Introductionmentioning

confidence: 99%

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

Applied Organom Chemis

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Cancer has become the second leading reason for death in the world. Cell biology states that the bulk of anti‐cancer medications focuses on DNA. A study of how complexes of metals interact with DNA is crucial in creation of the effective chemotherapy drugs. The interactions of DNA with Schiff base and their metal complexes are a thrust area for many researchers, and many papers have reported on them. An amino molecule reacts with carbonyl group to form a variety of chemicals called Schiff bases. Many studies have shown that Schiff bases have compounds that affect biological processes. Due to their potential use as novel reagents for biotechnology and medicine, the research of interactions between transition metal complexes and nucleic acids has grown significantly during the past few decades. It was shown that several metal Schiff base complexes may intercalate DNA. Small molecules can attach themselves to DNA through different ways, such as intercalation and groove binding. The main method to measure nuclease activity was gel electrophoresis, and the ligand alone had much lower activity than the complex. To set the stage for this analysis, a brief overview of Schiff bases and their complexes is provided. Further, this review provides an overview of the DNA interactions brought forth by Schiff base metal complexes. It also draws attention to new developments in the study of Schiff bases and their metal complexes and their prospective use as a bioactive core for DNA cleavage and binding.

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“…Hugo Schiff, a German chemist, initially reported Schiff base in 1864 [1]. Schiff bases are organic molecules formed via condensation reaction of carbonyl compounds and primary amines [2]. The typical structure can be expressed as R'-CR = N-R", where R, R' and R" might vary.…”

Section: Introductionmentioning

confidence: 99%

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

Meena¹,

Meena²,

Kumari³

et al. 2023

Schiff Base in Organic, Inorganic and Physical Chemistry

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The development of Schiff base was a major step forward in the area of coordination chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (>C=N–) functional group. Schiff bases played an influencing role in the development of coordination chemistry and were a key point in the development of inorganic, bioinorganic chemistry and optical materials. Schiff bases, widely used in inorganic, organic, and analytical chemistry, account for a significant portion of the more commonly employed classes of organic molecules. The ability of Schiff base ligands to form stable metal complexes with a wide range of transition and other metal ions makes them extremely useful. Condensation of a primary amine with an aldehyde or ketone yields a Schiff bases. In this chapter, we focused on introducing Schiff bases, classified them and their metal complexes, and discussed several synthesis methods, including conventional and green approaches. This chapter also elaborated on the industries’ applications, such as the food industry, agrochemical industry, dye industry, analytical chemistry, catalysis, energy storage, environmental, chemo-sensing, bio-sensing, and biomedical applications of novel Schiff bases and their metal complexes.

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Schiff Base Metal Complexes as Antimicrobial and Anticancer Agents

Cited by 15 publications

References 111 publications

Unveiling the biomedical potential of thiophene‐derived Schiff base complexes: A comprehensive study of synthesis, spectral characterization, antimicrobial efficacy, antioxidant activity, and computational insights

Unveiling the biomedical potential of thiophene‐derived Schiff base complexes: A comprehensive study of synthesis, spectral characterization, antimicrobial efficacy, antioxidant activity, and computational insights

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

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