Schiff Base Copper(II) and Zinc(II) Complexes: Synthesis, Structures, and Antimicrobial Activities

Abstract

A new halo-substituted Schiff base ligand 2-bromo-6-[(2-ethylaminoethylimino)methyl]phenol (HL) and its copper(II) and zinc(II) complexes [Cu 2 L 2 (m 1,1 -NCS) 2 ] (1) and [ZnCl 2 (HL)] (2) (HL is the zwitterionic form of the Schiff base ligand) have been prepared and characterized by elemental analyses, IR, and single-crystal X-ray crystallographic determination. The crystal of (1) is monoclinic: space group P2 1 /c, a D 10.909 (1), b D 13.976(1), c D 10.161(1) A , b D 111.471(2) , V D 1441.7(2) A 3 , Z D 2. The crystal of (2) is monoclinic: space group P2 1 /n, a D 7.2682(4), b D 20.195(1), c D 10.8447(6) A , b D 106.420(2) , V D 1526.9(2) A 3, Z D 4. The Cu atoms in the copper complex are in square pyramidal coordination. The Zn atom in the zinc complex is in tetrahedral coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans were studied.

New Metal Complexes With Aril-Acetic Structure: Preparation, Characterization, and in Vitro Antiinflammatory Effects

“…The resulting product was separated by vacuum filtration, and then purified by silica gel column chromatography (petroleum ether:ethyl acetate solvent system = 8:2, v/v) [12,15]. To prepare the metal complexes, the diclofenac hydrazones (1a-d, 2 mmol) were dissolved in ethanol (30 mL), and after that, the bivalent metal salts (Cu(CH3COO)2•H2O, Zn(CH3COO)2•2H2O and Ni(CH3COO)2•4H2O (1 mmol) as an ethanolic solution (10 mL) were added [40,42,48]. The resulted mixture was refluxed for 2 -5 h to form the metal complexes ( 2a-d, 3a-d, and 4a-d) (Figure 1).…”

Synthesis of Some New Carbazole-Metal Complexes and Their Thermal, Electronic, Spectral and Catalytic Alkene Oxidation Properties

“…Schiff base complexes were and are still being examined for their catalytic activities towards many different organic reactions [11][12][13][14][15]. Also, various Schiff base ligands are being examined for their biological effects like antimicrobial, anticancer and antitumour activities [16][17][18][19][20][21]. In many research carried out worldwide use carbazole moiety in the syntheses of new organic compounds and these organic compounds have been studied for their various features like thermal, electrochemical, electroluminescent features [22], as catalysts for the hydrogenation of alkenes [23], as ligands toward catalytic nitrogen fixation [24] and as photosensitizers (PS) [25].…”