Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer

Kawakami, Jiro; T, Abe; Higaki, Eiji; Hosoi, Takahiro; Fukaya, Masahide; Kono, Koji; Ito, Seiji; Nakatochi, Masahiro; Nagino, Masato; Shimizu, Yasuhiro

doi:10.1007/s00595-020-02001-x

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…All patients with thoracic esophageal cancer underwent either transthoracic esophagectomy in the left lateral decubitus position or thoracoscopic esophagectomy in the prone position with mediastinal lymphnodedissection. 16 Afterthethoracicprocedure,abdominallymph nodedissectionandgastricconduitreconstructionwereperformedusing either open laparotomy or hand-assisted laparoscopic surgery. An approximately 4-cm gastric conduit that partially preserved the greater omentum was created using a linear stapler of 2 rows in both groups.…”

Section: Esophagectomy With Lymph Node Dissection and Gastric Conduit...mentioning

confidence: 99%

Circular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy

Hosoi

T²,

Higaki³

et al. 2021

Annals of Surgery

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Objective: This study was performed to investigate the efficacy of the modified Collard (MC) technique for reducing anastomotic stricture after esophagectomy compared with the circular stapled (CS) technique. Summary Background Data: The currently available techniques of anastomosis after esophagectomy are associated with a significant risk of anastomotic complications. However, the optimal anastomotic technique after esophagectomy has not yet been established. Methods: We randomly allocated patients to either the CS group or the MC group. The primary endpoint was the incidence of anastomotic stricture. The secondary endpoints included the incidence of postoperative complications (including anastomotic leakage) and quality of life (QoL). All anastomoses were performed after indocyanine green evaluation for objective homogenization of blood flow to the gastric conduit between the 2 techniques. Results: Among 100 randomized patients (CS group, n ¼ 50; MC group, n ¼ 50), anastomotic strictures were observed in 18 (42%) patients in the CS group and in no patients in the MC group. There were no significant between-group differences in anastomotic leakage (CS group, 7% vs MC group, 8%; P ¼ 0.94). Quality of life domains of dysphagia and choking when swallowing at 3 months after surgery were significantly better in the MC group than in the CS group. Conclusions: The MC technique reduces the incidence of anastomotic stricture and improves postoperative quality of life. Furthermore, the incidence of anastomotic leakage is comparable between the 2 techniques based on accurate comparison under objective homogenization of the gastric conduit condition.

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Section: Esophagectomy With Lymph Node Dissection and Gastric Conduit...mentioning

confidence: 99%

Circular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy

Hosoi

T²,

Higaki³

et al. 2021

Annals of Surgery

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“…In that report, scheduled IAA was associated with a lower incidence of anastomotic leakage and postoperative delirium than the scheduled oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs). 5 In contrast to NSAIDs, acetaminophen does not reduce collagen production and does not impair angiogenesis via the downregulation of prostaglandins through cyclooxygenase inhibition. Acetaminophen is thought to have central analgesic properties and its anti-inflammatory effect on the central nerve system.…”

Section: Discussionmentioning

confidence: 99%

“…2,5-7 However, previous reports have shown that IAA was little associated with the dose of opioid or NSAIDs. 3,5 In elderly patients, ibuprofen and other NSAIDs are not recommended because of the risk of Reye's syndrome, the mechanism of which is unknown. 12 Opioids and pentazocine, an agonist-antagonist of opioids, should also be avoided in children because of the associated severe side effects and risk of abuse.…”

Section: Discussionmentioning

confidence: 99%

“…For adult patients, intravenous administration of acetaminophen (IAA) was suggested in various publications as part of a postoperative multimodal pain management regimen. [4][5][6][7][8] In our country, the IAA has become a standard method of postoperative analgesic management for pediatric surgery in the past few years. However, the most effective methods of IAA for acute appendicitis are unclear.…”

Section: Introductionmentioning

confidence: 99%

“…An intravenous administration of acetaminophen (Acelio Intravenous Injection®; TERUMO Co. Ltd., Tokyo, Japan) is used as a postoperative analgesic agent for patients of all ages. For adult patients, intravenous administration of acetaminophen (IAA) was suggested in various publications as part of a postoperative multimodal pain management regimen 4–8 . In our country, the IAA has become a standard method of postoperative analgesic management for pediatric surgery in the past few years.…”

Section: Introductionmentioning

confidence: 99%

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The analgesic effect of the intravenous administration of acetaminophen for pediatric laparoscopic appendectomy: A comparison of scheduled and on‐demand procedures

Yano

Muto

Nagai

et al. 2022

Asian J Endoscop Surgery

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Purpose: The intravenous administration of acetaminophen (IAA) has become standard postoperative analgesic management for pediatric surgery.However, the most effective methods of IAA for postoperative acute appendicitis are unclear. We evaluated the analgesic efficacy of scheduled IAA vs ondemand IAA for postoperative acute appendicitis.Methods: Ninety-four patients who underwent laparoscopic appendectomy in our institution between January 2017 and December 2020 were enrolled. The patients were divided into two groups based on the postoperative pain control protocols. The scheduled IAA group (SA group, n = 42) was managed by scheduled IAA and additional on-demand use of pentazocine as rescue therapy. The on-demand IAA group (ODA group, n = 52) was managed by ondemand IAA as the first choice, with pentazocine as the second choice for pain control. The patients' background characteristics, operative results and postoperative outcomes were reviewed. Results:The number of times pain complaints were made per patient per day (NPPD) on postoperative days (POD) 1 and 2 was significantly lower in the SA group than in the ODA group (POD 1; 1.12 ± 1.21 vs 2.62 ± 1.89, p < 0.01; POD 2; 0.45 ± 0.86 vs. 1.31 ± 1.69, p < 0.01). According to pathological findings, NPPD was lower in the SA group than in the ODA group for both phlegmonous appendicitis (0.71 ± 1.01 vs. 2.10 ± 2.13, P < .05) and gangrenous appendicitis (1.33 ± 1.50 vs 2.94 ± 1.68, P < .01). On POD 2, the incidence of gangrenous appendicitis was significantly lower in the SA group than in the ODA group (0.57 ± 0.93 vs 1.78 ± 1.86, P < .01). Conclusions: Scheduled IAA may have favorable efficacy for postoperative pain control after emergency surgery for acute appendicitis in pediatric patients.

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Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen

Han

Zhang²,

Hua³

et al. 2022

Med Chem Res

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Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer

Cited by 8 publications

References 26 publications

Circular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy

Circular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy

The analgesic effect of the intravenous administration of acetaminophen for pediatric laparoscopic appendectomy: A comparison of scheduled and on‐demand procedures

Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen

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