We study continuity and Hölder continuity of t → Ptf , where Pt is a generalized Mehler semigroup in C b (X), the space of the continuous and bounded functions from a Banach space X to R, and f ∈ C b (X). The generators L of such semigroups are realizations of a class of differential and pseudo-differential operators, both in finite and in infinite dimension. Examples of operators L to which this theory is applicable include Ornstein-Uhlenbeck operators with fractional diffusion in finite dimension, and Ornstein-Uhlenbeck operators with associated strong-Feller semigroups, in infinite dimension.