Schaftoside improves cerebral ischemia-reperfusion injury by enhancing autophagy and reducing apoptosis and inflammation through the AMPK/mTOR pathway

Zhang, Lin; Wu, Minxian; Chen, Zhaoyao

doi:10.17219/acem/152207

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Next, pretreatment with eugenol attenuated ischemia–reperfusion brain injury in rats by inducing autophagy via the AMPK/mTOR/P70S6K signaling pathway [ 111 ]. Another study indicated that schaftoside blocked apoptosis and neuroinflammation, reducing brain edema and improving neurologic deficits by enhancing autophagy after transient focal brain ischemia in rats [ 117 ].…”

Section: Autophagy Versus Postischemic Brain Injurymentioning

confidence: 99%

The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy

Pluta

2023

IJMS

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Autophagy is a self-defense and self-degrading intracellular system involved in the recycling and elimination of the payload of cytoplasmic redundant components, aggregated or misfolded proteins and intracellular pathogens to maintain cell homeostasis and physiological function. Autophagy is activated in response to metabolic stress or starvation to maintain homeostasis in cells by updating organelles and dysfunctional proteins. In neurodegenerative diseases, such as cerebral ischemia, autophagy is disturbed, e.g., as a result of the pathological accumulation of proteins associated with Alzheimer’s disease and their structural changes. Postischemic brain neurodegeneration, such as Alzheimer’s disease, is characterized by the accumulation of amyloid and tau protein. After cerebral ischemia, autophagy was found to be activated in neuronal, glial and vascular cells. Some studies have shown the protective properties of autophagy in postischemic brain, while other studies have shown completely opposite properties. Thus, autophagy is now presented as a double-edged sword with possible therapeutic potential in brain ischemia. The exact role and regulatory pathways of autophagy that are involved in cerebral ischemia have not been conclusively elucidated. This review aims to provide a comprehensive look at the advances in the study of autophagy behavior in neuronal, glial and vascular cells for ischemic brain injury. In addition, the importance of autophagy in neurodegeneration after cerebral ischemia has been highlighted. The review also presents the possibility of modulating the autophagy machinery through various compounds on the development of neurodegeneration after cerebral ischemia.

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Section: Autophagy Versus Postischemic Brain Injurymentioning

confidence: 99%

The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy

Pluta

2023

IJMS

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“…Soyasaponin Bb exhibits significant anti‐thrombosis and hypolipidemic activities and could ameliorate obesity and reduce hepatic triacylglycerol accumulation by suppressing lipogenesis in high‐fat diet‐fed mice (Tsai et al, 2021). Schaftoside was the representative flavone and could improve cerebral ischemia–reperfusion injury by enhancing autophagy and reducing apoptosis and inflammation (Zhang et al, 2022), and exhibited anti‐epileptic effect by suppressing apoptosis and modulating inflammation (Dang et al, 2021). In addition, schaftoside could activate Farnesoid X Receptor and exhibited hepatoprotective activity by modulating oxidative stress and inflammation (Liu, Zhang, Song, et al, 2020; Liu, Zhang, Wu, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study after oral administration of Abrus cantoniensis Hance extract

Zhang¹,

Bu²,

Li³

et al. 2023

Biomedical Chromatography

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A simple and sensitive liquid chromatography tandem mass spectrometry method was established and validated for the quantitative determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma. After preparation by protein precipitation with acetonitrile, the analytes and internal standard were separated on a Waters CORTECS T3 column using acetonitrile containing 0.1% formic acid and 0.1% formic acid in water as mobile phase by gradient elution in 2 min. The method showed excellent linearity over the range of 5–500 ng/ml with acceptable intra‐ and inter‐day precision, accuracy, matrix effect and recovery. The stability assay indicated that the four analytes were stable during the analysis process. The method was applied to a pharmacokinetic study of Abrus cantoniensis Hance in rats. The result suggested that after oral administration, the four analytes were quickly absorbed into the plasma. The dose‐normalized exposure of hypaphorine was the highest with a long elimination half‐life (t1/2 9.83 h), followed by abrine and schaftoside with t1/2 values of 1.07 and 1.15 h. The dose normalized exposure of soyasaponin Bb was the lowest, which is possibily due to the high polarity and poor permeability. This study provides a basis for elucidating the material foundation of A. cantoniensis Hance.

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Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury

et al. 2023

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Schaftoside improves cerebral ischemia-reperfusion injury by enhancing autophagy and reducing apoptosis and inflammation through the AMPK/mTOR pathway

Abstract: improves cerebral ischemia-reperfusion injury by enhancing autophagy and reducing apoptosis and inflammation through the AMPK/ mTOR pathway [published online as ahead of print on September 22, 2022].

Cited by 6 publications

References 66 publications

The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy

The Dual Role of Autophagy in Postischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy

Simultaneous determination of abrine, hypaphorine, schaftoside and soyasaponin Bb in rat plasma by UPLC–MS/MS and its application to a pharmacokinetic study after oral administration of Abrus cantoniensis Hance extract

Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia–reperfusion injury

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