Sch 65676: A novel fungal metabolite with the inhibitory activity against the cytomegalovirus protease

Chen, Min; Mierzwa, Ronald; Truumees, Imbi; King, Arthur; Patel, Mahesh; Pichardo, John; Hart, Andrea; Dasmahapatra, Bimal; Das, Pradip R.; Puar, Mohindar S.

doi:10.1016/0040-4039(96)00748-4

Cited by 21 publications

(14 citation statements)

References 4 publications

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“…It exhibited in vitro inhibitory activity against the CMV protease with an IC 50 value of 9.8 µg/ml. 181 …”

Section: Fungal Metabolite Inhibitors For Various Viral Diseasesmentioning

confidence: 99%

“…Seventeen new and known lactones including eight territrem and nine butyrolactone derivatives were isolated from a marine-derived fungus A. terreus SCSGAF0162 under solid-state fermentation of rice. 170 Among these, four butyrolactone derivatives, 11 a-dehydroxyiso-terreulactone A [178], isobutyrolactone II [179], aspernolide A [180], and arisugacin A [181] exhibited moderate HSV-1 antiviral activity with IC 50 values of 16.4, 21.8, 28.9, and 6.34 mg/ml, respectively, under their noncytotoxic concentrations (TC 0 ) on Vero cell line.…”

Section: Inhibitors For Herpes Virusesmentioning

confidence: 99%

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Potential of small-molecule fungal metabolites in antiviral chemotherapy

Roy

2017

Antivir Chem Chemother

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Various viral diseases, such as acquired immunodeficiency syndrome, influenza, and hepatitis, have emerged as leading causes of human death worldwide. Scientific endeavor since invention of DNA-dependent RNA polymerase of pox virus in 1967 resulted in better understanding of virus replication and development of various novel therapeutic strategies. Despite considerable advancement in every facet of drug discovery process, development of commercially viable, safe, and effective drugs for these viruses still remains a big challenge. Decades of intense research yielded a handful of natural and synthetic therapeutic options. But emergence of new viruses and drug-resistant viral strains had made new drug development process a never-ending battle. Small-molecule fungal metabolites due to their vast diversity, stereochemical complexity, and preapproved biocompatibility always remain an attractive source for new drug discovery. Though, exploration of therapeutic importance of fungal metabolites has started early with discovery of penicillin, recent prediction asserted that only a small percentage (5–10%) of fungal species have been identified and much less have been scientifically investigated. Therefore, exploration of new fungal metabolites, their bioassay, and subsequent mechanistic study bears huge importance in new drug discovery endeavors. Though no fungal metabolites so far approved for antiviral treatment, many of these exhibited high potential against various viral diseases. This review comprehensively discussed about antiviral activities of fungal metabolites of diverse origin against some important viral diseases. This also highlighted the mechanistic details of inhibition of viral replication along with structure–activity relationship of some common and important classes of fungal metabolites.

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“…It exhibited in vitro inhibitory activity against the CMV protease with an IC 50 value of 9.8 µg/ml. 181 …”

Section: Fungal Metabolite Inhibitors For Various Viral Diseasesmentioning

confidence: 99%

Section: Inhibitors For Herpes Virusesmentioning

confidence: 99%

Potential of small-molecule fungal metabolites in antiviral chemotherapy

Roy

2017

Antivir Chem Chemother

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“…Compound 47 and its oxidized derivatives have been shown to inhibit complement [54,441,442]. Interestingly, several simplified analogs of 47 exerted similar complement inhibitory effects, which indicated that the spirobenzofuran unit was a key functional group for the retention of its bioactivity [443].…”

Section: Inflammatory Immunological and Related Disease Areasmentioning

confidence: 99%

Drimane-Related Merosesquiterpenoids, a Promising Library of Metabolites for Drug Development

Shan

Ying

et al. 2015

Studies in Natural Products Chemistry

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“…1 Development of new approaches for the construction of spirocyclic compounds is an interesting and challenging assignment in organic synthesis. As we know, spirobenzofuran framework is a key structural motif in organic and medicinal chemistry owing to its potency and wide spectrum of biological activities such as anticonvulsant, 2 human cytomegalovirus protease inhibitors, 3 antifungal, 4 and many others ( Fig. 1, AeC).…”

Section: Introductionmentioning

confidence: 99%

One-pot reaction for the concise synthesis of spiro[benzofuran-2,2′-naphthalen]-1′-one derivatives

Liu

et al. 2014

Tetrahedron

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Sch 65676: A novel fungal metabolite with the inhibitory activity against the cytomegalovirus protease

Cited by 21 publications

References 4 publications

Potential of small-molecule fungal metabolites in antiviral chemotherapy

Potential of small-molecule fungal metabolites in antiviral chemotherapy

Drimane-Related Merosesquiterpenoids, a Promising Library of Metabolites for Drug Development

One-pot reaction for the concise synthesis of spiro[benzofuran-2,2′-naphthalen]-1′-one derivatives

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