SCFD1 in amyotrophic lateral sclerosis: reconciling a genetic association with in vivo functional analysis

Cauchi, Ruben J.

doi:10.4103/1673-5374.386411

Neural Regeneration Research

2023

DOI: 10.4103/1673-5374.386411

|View full text |Cite

SCFD1 in amyotrophic lateral sclerosis: reconciling a genetic association with in vivo functional analysis

Ruben J. Cauchi

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

SNARE chaperone Sly1 directly mediates close-range vesicle tethering

Duan,

Plemel,

Takenaka

et al. 2024

Journal of Cell Biology

View full text Add to dashboard Cite

The essential Golgi protein Sly1 is a member of the Sec1/mammalian Unc-18 (SM) family of SNARE chaperones. Sly1 was originally identified through remarkable gain-of-function alleles that bypass requirements for diverse vesicle tethering factors. Employing genetic analyses and chemically defined reconstitutions of ER–Golgi fusion, we discovered that a loop conserved among Sly1 family members is not only autoinhibitory but also acts as a positive effector. An amphipathic lipid packing sensor (ALPS)-like helix within the loop directly binds high-curvature membranes. Membrane binding is required for relief of Sly1 autoinhibition and also allows Sly1 to directly tether incoming vesicles to the Qa-SNARE on the target organelle. The SLY1-20 mutation bypasses requirements for diverse tethering factors but loses this ability if the tethering activity is impaired. We propose that long-range tethers, including Golgins and multisubunit tethering complexes, hand off vesicles to Sly1, which then tethers at close range to initiate trans-SNARE complex assembly and fusion in the early secretory pathway.

show abstract

SNARE chaperone Sly1 directly mediates close-range vesicle tethering

Duan,

Plemel,

Takenaka

et al. 2024

Journal of Cell Biology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

SCFD1 in amyotrophic lateral sclerosis: reconciling a genetic association with in vivo functional analysis

Cited by 1 publication

References 13 publications

SNARE chaperone Sly1 directly mediates close-range vesicle tethering

SNARE chaperone Sly1 directly mediates close-range vesicle tethering

Contact Info

Product

Resources

About