SCF-Engineered Powders for Delivery of Budesonide from Passive DPI Devices

A combinational supercritical CO2 system for nanoparticle preparation of indomethacin

“…Fine particle formation of IMC When a drug solution and scCO 2 was expanded via the coaxial nozzle into the scCO 2 purged high-pressure vessel, IMC crystals were precipitated, since scCO 2 in the vessel acts as an antisolvent (Lobo et al, 2005;Tong et al, 2001;Schiavone et al, 2004). If the reaction vessel was kept at pressures below 10 MPa, microparticles of IMC were obtained in the vessel, without forming IMC nanoparticles (data not shown).…”

“…For this purpose scCO 2 has been used in two different ways: as a solvent for drug substance, or as an antisolvent for the precipitation of materials dissolved in organic solvents. Because of the low solubility of active pharmaceutical ingredients (APIs) in scCO 2 (Shinozaki et al, 2006), the majority of methods investigated use scCO 2 as an antisolvent, i.e., gas antisolvent technique (GAS) (Yeo and Lee, 2004;Bakhbakhi et al, 2006;González et al, 2000), the supercritical antisolvent precipitation technique (SAS) (Reverchon et al, 1998), the aerosol solvent extraction system technique (ASES) (Kunastitchai et al, 2006), and the solution enhanced dispersion with supercritical fluid technique (SEDS) (Lobo et al, 2005;Tong et al, 2001;Schiavone et al, 2004). Antisolvent processes have been used to crystallize many types of solid compounds from their solutions.…”

Amorphous Solid Dispersion Using Supercritical Fluid Technology

“…These techniques have successfully been used in the production of microand nanoparticles as well as ASDs to achieve particle size control and solubility. The ability to produce narrow particle size distribution with desired morphology has been extensively used in designing drug products for inhalation (York 1999;Lobo et al 2005;Badens et al 2009;Ayad et al 2013). …”

Particle formation of budesonide from alcohol-modified subcritical water solutions

“…Micronization of budesonide via supercritical antisolvent (precipitation) techniques requires the use of methylene chloride or acetone as a solvent (with CO 2 as the antisolvent) (Lobo et al, 2005;Martin et al, 2002). These solvents are toxic and can be difficult to remove from the drug matrix post-micronization, particularly in the low levels required for pharmaceutical application (Lakatos, 2008).…”