Sceletium tortuosum and depression: mechanisms elucidated

Bennett, AC; López, Víctor; Camp, Alyssa Van; Smith, Carine

doi:10.1055/s-0036-1596865

Cited by 1 publication

(2 citation statements)

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“…This showed that the dual 5-HT reuptake and PDE4 effects had anxiolytic activity by attenuating the subcortical threat swiftly [ 48 ]. Bennett et al [ 49 ] further showed the anti-stress effectiveness of Sceletium alkaloids, which affected the central enzymes (MAO-A) thus, preventing the adrenal steroidogenesis by blocking the CYP17, 3βHSD, and 17βHSD. With regard to the above, this showed the tremendous potential of the Sceletium plant as an anti-stress agent [ 49 ].…”

Section: Biological and Pharmaceutical Properties Of Sceletium Spmentioning

confidence: 99%

“…Bennett et al [ 49 ] further showed the anti-stress effectiveness of Sceletium alkaloids, which affected the central enzymes (MAO-A) thus, preventing the adrenal steroidogenesis by blocking the CYP17, 3βHSD, and 17βHSD. With regard to the above, this showed the tremendous potential of the Sceletium plant as an anti-stress agent [ 49 ]. Stress and depression have a strong association with each other and can lead to serious life-threatening outcomes.…”

Section: Biological and Pharmaceutical Properties Of Sceletium Spmentioning

confidence: 99%

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A Chewable Cure “Kanna”: Biological and Pharmaceutical Properties of Sceletium tortuosum

et al. 2021

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Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. Today, the plant has gained strong global attraction and reputation due to its capabilities to promote a sense of well-being by relieving stress with calming effects. Historically, the plant was used by native San hunter-gatherers and Khoi people to quench their thirst, fight fatigue and for healing, social, and spiritual purposes. Various studies have revealed that extracts of the plant have numerous biological properties and isolated alkaloids of Sceletium tortuosum are currently being used as dietary supplements for medicinal purposes and food. Furthermore, current research has focused on the commercialization of the plant because of its treatment in clinical anxiety and depression, psychological and psychiatric disorders, improving mood, promoting relaxation and happiness. In addition, several studies have focused on the isolation and characterization of various beneficial bioactive compounds including alkaloids from the Sceletium tortuosum plant. Sceletium was reviewed more than a decade ago and new evidence has been published since 2008, substantiating an update on this South African botanical asset. Thus, this review provides an extensive overview of the biological and pharmaceutical properties of Sceletium tortuosum as well as the bioactive compounds with an emphasis on antimicrobial, anti-inflammatory, anti-oxidant, antidepressant, anxiolytic, and other significant biological effects. There is a need to critically evaluate the bioactivities and responsible bioactive compounds, which might assist in reinforcing and confirming the significant role of kanna in the promotion of healthy well-being in these stressful times.

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Section: Biological and Pharmaceutical Properties Of Sceletium Spmentioning

confidence: 99%

Section: Biological and Pharmaceutical Properties Of Sceletium Spmentioning

confidence: 99%