Scedosporium apiospermum pneumonia after autologous bone marrow transplantation

García-Arata, M. Isabel; Otero, María José; Zomeño, M; Figuera, M A de la; Cuevas, Monica Caba; López‐Brea, Marta

doi:10.1007/bf01709371

Cited by 22 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the late development of pulmonary scedosporiosis in the SOT population, the disease has been reported to occur soon after HSCT, generally during the preengraftment period (21,140,374,410,411). However, as HSCT practices change, we are witnessing a changing epidemiology of opportunistic fungal infections (i.e., aspergillosis, zygomycosis, scedosporiosis, etc).…”

Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

View full text Add to dashboard Cite

SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

show abstract

Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Treatment includes surgical debridement, if possible, and antifungal chemotherapy, although the optimal choice and duration of therapy are unknown. Azoles, such as miconazole and itraconazole, have been used with some success for the treatment of invasive infections with Scedosporium apiospermum (6), but treatment failures have also been reported (15). S. prolificans is considered multiresistant since low in vitro activities have been reported for amphotericin B, flucytosine, and the azoles (3).…”

mentioning

confidence: 98%

In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans

Meletiadis

Mouton

Rodríguez-Tudela

et al. 2000

Antimicrob Agents Chemother

102

View full text Add to dashboard Cite

In order to develop new approaches for the chemotherapy of invasive infections caused by Scedosporium prolificans, the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.

show abstract

“…S. apiospermum is usually resistant in vitro and in vivo to commonly available antifungal agents, such as itraconazole and amphotericin. There are, however, reports of successful treatment with both systemic miconazole and ketoconazole (2,16), in some cases combined with surgery (3). Scedosporium respiratory tract colonization is regarded as a relative but not absolute contraindication to lung transplantation (11).…”

mentioning

confidence: 99%

Molecular Epidemiology of Scedosporium apiospermum Infection Determined by PCR Amplification of Ribosomal Intergenic Spacer Sequences in Patients with Chronic Lung Disease

et al. 2001

View full text Add to dashboard Cite

Respiratory tract colonization with Scedosporium apiospermum in patients with chronic suppurative lung disease is a significant concern for lung transplantation candidates, since Scedosporium infections occurring posttransplantation are usually untreatable. Up to 10% of patients with cystic fibrosis attending our respiratory medicine unit have had Scedosporium organisms isolated from sputum samples. We therefore developed a molecular typing method to examine these isolates. Typing by PCR amplification of ribosomal intergenic spacer sequences demonstrated 20 different types from 52 isolates collected from the respiratory medicine unit and elsewhere in Australia. A single common type was isolated from 11 respiratory medicine unit inpatients. Two other types were isolated from more than one source: one from two respiratory medicine unit inpatients and one from two epidemiologically linked nonhuman sources. Multiple isolates were obtained from nine patients. This method demonstrated persistent carriage of isolates of the same type in one patient for 7 months. Two patients showed carriage of isolates with multiple typing patterns within a 3-month period. The high rate of isolation and the predominance of isolates with a single typing pattern from respiratory medicine unit patients may suggest transmission to patients from a source in the unit. There was no epidemiological evidence of direct patient-to-patient spread, and Scedosporium organisms were not isolated from dust, soil, or air samples from the unit. The source and route of transmission have yet to be determined.

show abstract

Scedosporium apiospermum pneumonia after autologous bone marrow transplantation

Cited by 22 publications

References 11 publications

Infections Caused byScedosporiumspp

Infections Caused byScedosporiumspp

In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans

Molecular Epidemiology of Scedosporium apiospermum Infection Determined by PCR Amplification of Ribosomal Intergenic Spacer Sequences in Patients with Chronic Lung Disease

Contact Info

Product

Resources

About