SCD1 promotes lipid mobilization in subcutaneous white adipose tissue

Zou, Ying; Wang, Yina; Ma, Hong; He, Zhijun; Tang, Yan; Guo, Liang; Liu, Yang; Ding, Meng; Qian, Shuwen; Tang, Qi‐Qun

doi:10.1194/jlr.ra120000869

Cited by 33 publications

(26 citation statements)

References 59 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent publication in our laboratory showed that BMP4 transcriptionally activates SCD1, an enzyme catalyzing the biosynthesis of unsaturated fatty acids. SCD1 promotes lipolysis and fat mobilization, which is fulfilled by the intermediate oleic acid ( 207 ). In fact, SCD1 accelerates both the synthesis and lysis of triglycerides, forming a somewhat futile cycle ( Fig.…”

Section: Bmp Signaling Participates In Multiple Processes Involving the Plasticity Of Adipose Tissuementioning

confidence: 99%

“…In fact, SCD1 accelerates both the synthesis and lysis of triglycerides, forming a somewhat futile cycle ( Fig. 4 ) ( 207 ). We posit that this futile cycle driven by SCD1 may prime lipids in an active state ready for both incorporation and release of fatty acid and thus quickly respond to stimulation inducing energy consumption or storage, such as fasting/feeding or cold/heat exposure.…”

Section: Bmp Signaling Participates In Multiple Processes Involving the Plasticity Of Adipose Tissuementioning

confidence: 99%

See 1 more Smart Citation

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

Qian

Tang

2021

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

Edited by John DenuAdipose tissues, including white, beige, and brown adipose tissue, have evolved to be highly dynamic organs. Adipose tissues undergo profound changes during development and regeneration and readily undergo remodeling to meet the demands of an everchanging metabolic landscape. The dynamics are determined by the high plasticity of adipose tissues, which contain various cell types: adipocytes, immune cells, endothelial cells, nerves, and fibroblasts. There are numerous proteins that participate in regulating the plasticity of adipose tissues. Among these, bone morphogenetic proteins (BMPs) were initially found to regulate the differentiation of adipocytes, and they are being reported to have pleiotropic functions by emerging studies. Here, in the first half of the article, we summarize the plasticity of adipocytes and macrophages, which are two groups of cells targeted by BMP signaling in adipose tissues. We then review how BMPs regulate the differentiation, death, and lipid metabolism of adipocytes. In addition, the potential role of BMPs in regulating adipose tissue macrophages is considered. Finally, the expression of BMPs in adipose tissues and their metabolic relevance are discussed.

show abstract

Section: Bmp Signaling Participates In Multiple Processes Involving the Plasticity Of Adipose Tissuementioning

confidence: 99%

Section: Bmp Signaling Participates In Multiple Processes Involving the Plasticity Of Adipose Tissuementioning

confidence: 99%

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

Qian

Tang

2021

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…In vivo and in vitro studies have shown that in adipose tissue SCD1 is involved in the promotion of lipid mobilization by enhancing lipolysis and lipogenesis [ 21 , 22 ]. SCD1 is a key enzyme involved in de novo lipogenesis and is responsible for the conversion of SFAs to MUFAs.…”

Section: Resultsmentioning

confidence: 99%

Branched-Chain Fatty Acids Alter the Expression of Genes Responsible for Lipid Synthesis and Inflammation in Human Adipose Cells

2022

View full text Add to dashboard Cite

Recently, we have demonstrated a decreased level of iso-branched-chain fatty acids (iso-BCFAs) in patients with excessive weight. However, it is still unclear whether BCFAs may influence lipid metabolism and inflammation in lipogenic tissues. To verify this, human visceral adipocytes were cultured with three different concentrations of selected iso-BCFA (14-methylpentadecanoic acid) and anteiso-BCFA (12-methyltetradecanoic acid), and then the expression of genes associated with lipid metabolism (FASN—fatty acid synthase; SREBP1—sterol regulatory element-binding protein 1; SCD1—stearoyl-CoA desaturase; ELOVL4—fatty acid elongase 4; ELOVL6—fatty acid elongase 6; FADS2—fatty acid desaturase 2; FADS1–fatty acid desaturase 1) and inflammation (COX-2—cyclooxygenase 2; ALOX-15—lipoxygenase 15; IL-6—interleukin 6) were determined. This study demonstrates for the first time that incubation with iso-BCFA decreases the expression of adipocyte genes that are associated with lipid metabolism (except FASN) and inflammation. These findings suggest that changes in the iso-BCFA profile in obese patients may contribute to adipose inflammation and dyslipidemia. Further studies should evaluate whether iso-BCFA supplementation in obese patients would be beneficial.

show abstract

“…Furthermore, SCD1 knockdown inhibited lipolysis in adipocytes by down-regulating lipases and reducing lipophagy. BMP4 was also demonstrated to be a crucial factor regulating SCD1 expression, up-regulating SCD1 expression through the Smad pathway [27].…”

Section: Discussionmentioning

confidence: 99%

The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle

Liu

Wang

et al. 2021

Animals

View full text Add to dashboard Cite

FATP1 plays an important role in the regulation of fatty acid metabolism and lipid accumulation. In this study, we investigated the patterns of FATP1 expression in various tissues obtained from calf and adult Qinchuan cattle, and in differentiating adipocytes. Next, we investigated the effect of FATP1 expression on preadipocyte differentiation in Qinchuan cattle using overexpression and interference assays. We also identified the differentially expressed genes (DEGs) and pathways associated with FATP1 overexpression/interference. Our results reveal that FATP1 was broadly expressed in heart, kidney, muscle, small intestine, large intestine, and perirenal fat tissues. While FATP1 overexpression promoted preadipocyte differentiation, fat deposition, and the expression of several genes involved in fat metabolism, FATP1 interference had the opposite effects on adipocyte differentiation. Following FATP1 overexpression and FATP1 interference in adipocytes, RNA-seq analysis was performed to identify DEGs related to fat metabolism. The DEGs identified include SLPI, STC1, SEMA6A, TNFRSF19, SLN, PTGS2, ADCYP1, FADS2, and SCD. Pathway analysis revealed that the DEGs were enriched in the PPAR signaling pathway, AMPK signal pathway, and Insulin signaling pathway. Our results provide an in-depth understanding of the function and regulation mechanism of FAPT1 in fat metabolism.

show abstract

SCD1 promotes lipid mobilization in subcutaneous white adipose tissue

Cited by 33 publications

References 59 publications

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

Adipose tissue plasticity and the pleiotropic roles of BMP signaling

Branched-Chain Fatty Acids Alter the Expression of Genes Responsible for Lipid Synthesis and Inflammation in Human Adipose Cells

The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle

Contact Info

Product

Resources

About