SCCA-IgM as a Potential Biomarker of Non-Alcoholic Fatty Liver Disease in Patients with Obesity, Prediabetes and Diabetes Undergoing Sleeve Gastrectomy

Bettini, Silvia; Bordigato, Emanuel; Milan, Gabriella; Prà, Chiara Dal; Favaretto, Francesca; Belligoli, Anna; Sanna, Marta; Serra, Roberto; Foletto, Mirto; Prevedello, Luca; Busetto, Luca; Fassina, Giorgio; Vettor, Roberto; Fabris, Roberto

doi:10.1159/000499717

Cited by 4 publications

(2 citation statements)

References 50 publications

(76 reference statements)

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“… 16 , 30 NAFLD has mutual influence with GDM 7 and a study among non-obese Chinese population without NAFLD at baseline reported the increase in the ALT/AST was associated with the risk of new-onset NAFLD. 17 Bettini et al 31 found ALT/AST decreased in patients with obesity after laparoscopic sleeve gastrectomy and was correlated with BMI and insulin reduction. Since insulin resistance, NAFLD and BMI are all closely related to the development of GDM, it is reasonable that ALT/AST presented close association with GDM and can be an independent risk factor of GDM.…”

Section: Discussionmentioning

confidence: 99%

ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C

Song¹,

Zhang²,

Xiaolin³

et al. 2022

IJGM

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Objective: This study aimed to find the association between alanine transaminase-toaspartate aminotransferase ratio (ALT/AST) and the incidence of gestational diabetes mellitus (GDM). Methods: A total of 1128 pregnant women were included in this prospective, double-center, observational cohort study. ALT, AST and total bilirubin (TBil) were tested during 6-12 weeks of gestation and 75-g oral glucose tolerance test (OGTT) was conducted during 24-28 weeks of gestation to screen GDM. The association between ALT/AST and glucose concentration during OGTT was analyzed by linear regression model. The OR with 95% CI for incidence of GDM associated with ALT/AST was estimated by binary logistic regression. The discriminatory values of ALT/AST and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) for GDM were calculated by the area under the receiver operating characteristic curve (ROC-AUC). Results: The incidence of GDM was 22.07% (249/1128). ALT/AST was higher in GDM group than in NGT group (0.92 [0.75, 1.18] vs 0.80[0.65, 1.02], P <0.001). ALT/AST had positive correlations with fasting blood glucose, 1-hour and 2-hour blood glucose concentration during OGTT (0.089 [95% CI: 0.034, 0.163], 0.176 [95% CI: 0.052, 0.104], and 0.115 [95% CI: 0.199, 0.609], respectively). The OR of ALT/AST for incidence of GDM was 1.603 (95% CI:1.097, 2.344). The ROC-AUC of ALT/AST and TG/HDL-C reached 0.615 (95% CI: 0.575, 0.655) and 0.619 (95% CI: 0.580, 0.659), respectively. Conclusion: ALT/AST in early pregnancy was an independent risk factor of GDM. The predictive ability of ALT/AST was similar to TG/HDL-C for GDM.

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Section: Discussionmentioning

confidence: 99%

ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C

Song¹,

Zhang²,

Xiaolin³

et al. 2022

IJGM

View full text Add to dashboard Cite

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“…Therefore, liver biopsy is not the ideal method for repeated assessments of disease progression, and new non-invasive procedures are needed. Several scores and indexes have been validated to detect advanced hepatic fibrosis in patients with NAFLD, such as the alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio, the AST-to-platelet ratio index (APRI), and the Fibrosis-4 Index (FIB-4) [ 27 , 28 , 29 , 30 ], and innovative biomarkers have been proposed in patients with obesity [ 31 ]. Moreover, imaging methods have been developed, such as transient elastography (TE), FibroScan ® , and shear wave elastography (SWE).…”

Section: Introductionmentioning

confidence: 99%

Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome

et al. 2021

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Alström syndrome (ALMS) is an ultra-rare monogenic disease characterized by insulin resistance, multi-organ fibrosis, obesity, type 2 diabetes mellitus (T2DM), and hypertriglyceridemia with high and early incidence of non-alcoholic fatty liver disease (NAFLD). We evaluated liver fibrosis quantifying liver stiffness (LS) by shear wave elastography (SWE) and steatosis using ultrasound sonographic (US) liver/kidney ratios (L/K) in 18 patients with ALMS and 25 controls, and analyzed the contribution of metabolic and genetic alterations in NAFLD progression. We also genetically characterized patients. LS and L/K values were significantly higher in patients compared with in controls (p < 0.001 versus p = 0.013). In patients, LS correlated with the Fibrosis-4 Index and age, while L/K was associated with triglyceride levels. LS showed an increasing trend in patients with metabolic comorbidities and displayed a significant correlation with waist circumference, the homeostasis model assessment, and glycated hemoglobin A1c. SWE and US represent promising tools to accurately evaluate early liver fibrosis and steatosis in adults and children with ALMS during follow-up. We described a new pathogenic variant of exon 8 in ALMS1. Patients with ALMS displayed enhanced steatosis, an early increased age-dependent LS that is associated with obesity and T2DM but also linked to genetic alterations, suggesting that ALMS1 could be involved in liver fibrogenesis.

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Metabolic Slowing Vanished 5 Years After Sleeve Gastrectomy in Patients With Obesity and Prediabetes/Diabetes

Bettini

Milan

Favaretto

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background Resting energy expenditure (REE) decreases after weight loss more than expected according to body composition changes. Metabolic adaptation (MA) or metabolic slowing represents the difference between measured (m) and predicted (p) REE and it is not clear if it persists in the long-term. The aim of this study is to evaluate MA occurring 1 year (V1) and 5 years (V5) after laparoscopic sleeve gastrectomy (LSG) in patients with obesity and normal glucose tolerance, prediabetes (preDM) and type 2 diabetes (T2DM). Methods We reassessed 37 patients (14M/23F) of 44.8±10 years old, since they registered all the biochemical, body composition and REE assessments at baseline (V0), V1 and V5. Physical activity (PA) was assessed by interview and questionnaire. Results Patients displayed a percentage of weight loss of 31.5±7.4% at V1 and a weight regain of 8.9±7.5% at V5. Comparing V1 and V5, fat mass showed a slight increase (p = 0.011), while free fat mass remained unchanged (p = 0.304). PA improved at V1 (p < 0.001), remaining stable at V5 (p = 0.9). mREE displayed a 31.2% reduction with a corresponding decrease of pREE of 21.4% at V1, compared with V0 (p = 0.005), confirming a significant MA at V1. Conversely, no difference between mREE and pREE was observed at V5 (p = 0.112). Conclusion Our results suggested that only patients with preDM and T2DM displayed MA at V1, that vanished 5 years after LSG. Patients who practised more PA prevent MA after surgery-induced wight loss.

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SCCA-IgM as a Potential Biomarker of Non-Alcoholic Fatty Liver Disease in Patients with Obesity, Prediabetes and Diabetes Undergoing Sleeve Gastrectomy

Cited by 4 publications

References 50 publications

ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C

ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C

Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome

Metabolic Slowing Vanished 5 Years After Sleeve Gastrectomy in Patients With Obesity and Prediabetes/Diabetes

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