SCC antigen - A specific marker for squamous cell carcinoma?

SCC Antigen in Malignant and Nonmalignant Squamous Lesions

“…Before treatment, positive rates of serum SCC Ag levels show differences as demonstrated in the different reports, ranging from 24 to 68% [24][25][26][27][28][29][30], but in all studies a correlation between progressive increases in SCC Ag serum levels and the progression of malignant disease was reported. Lesions of the oral cavity showed higher percentages of elevated SCC Ag serum levels than those of the larynx.…”

“…Although rising SCC antigen levels in the postoperative follow-up of patients with SCC indicated very early tumor relapse, these results are of minor clinical utility due to the absence of curative therapy [42]. In SCC of the lung serum, SCC Ag is a useful marker with a positive rate ranging from 26-57% [25,[43][44][45][46][47][48][49][50][51][52][53]. The positive rates correlated with the stage [25,43,53,54] and were increased in advanced stages in 61% [45,48].…”

“…In SCC of the lung serum, SCC Ag is a useful marker with a positive rate ranging from 26-57% [25,[43][44][45][46][47][48][49][50][51][52][53]. The positive rates correlated with the stage [25,43,53,54] and were increased in advanced stages in 61% [45,48]. Some authors indicated that the low sensitivity of primary tumors can be partially explained by the proportion of poorly differentiated SCC [50].…”